PMID- 3512995
OWN - NLM
STAT- MEDLINE
DCOM- 19860328
LR  - 20190702
IS  - 0027-5107 (Print)
IS  - 0027-5107 (Linking)
VI  - 169
IP  - 3
DP  - 1986 Mar
TI  - Comparison of the mutagenic activity of 5-hydroxymethyldeoxyuridine with 
      5-substituted 2'-deoxyuridine analogs in the Ames Salmonella/microsome test.
PG  - 123-7
AB  - 4 antiviral drugs 5-hydroxymethyldeoxyuridine (HMUdR), 5-trifluorothymidine 
      (F3TdR), 5-methoxymethyldeoxyuridine (MMUdR) and 5-ethyldeoxyuridine (EtUdR) have 
      been evaluated for mutagenic activity in the Ames Salmonella/microsome test. The 
      antimetabolites F3TdR and HMUdR were mutagenic in a dose-dependent manner in 
      strain TA100. F3TdR also was mutagenic in strain TA1535. Rat-liver 
      post-mitochondrial supernatant (S9) was not required for mutagenicity.
FAU - Bilimoria, M H
AU  - Bilimoria MH
FAU - Gupta, S V
AU  - Gupta SV
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mutat Res
JT  - Mutation research
JID - 0400763
RN  - 5116-24-5 (5-hydroxymethyl-2'-deoxyuridine)
RN  - VC2W18DGKR (Thymidine)
RN  - W78I7AY22C (Deoxyuridine)
SB  - IM
MH  - Animals
MH  - Deoxyuridine/*analogs & derivatives/pharmacology
MH  - Male
MH  - Microsomes, Liver/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Salmonella typhimurium/drug effects
MH  - Structure-Activity Relationship
MH  - Thymidine/*analogs & derivatives/pharmacology
EDAT- 1986/03/01 00:00
MHDA- 1986/03/01 00:01
CRDT- 1986/03/01 00:00
PHST- 1986/03/01 00:00 [pubmed]
PHST- 1986/03/01 00:01 [medline]
PHST- 1986/03/01 00:00 [entrez]
AID - 0165-1218(86)90091-1 [pii]
AID - 10.1016/0165-1218(86)90091-1 [doi]
PST - ppublish
SO  - Mutat Res. 1986 Mar;169(3):123-7. doi: 10.1016/0165-1218(86)90091-1.