PMID- 35130687
OWN - NLM
STAT- MEDLINE
DCOM- 20221205
LR  - 20221228
IS  - 2233-6087 (Electronic)
IS  - 2233-6079 (Print)
IS  - 2233-6079 (Linking)
VI  - 46
IP  - 6
DP  - 2022 Nov
TI  - Sex Differences in the Effects of CDKAL1 Variants on Glycemic Control in Diabetic 
      Patients: Findings from the Korean Genome and Epidemiology Study.
PG  - 879-889
LID - 10.4093/dmj.2021.0265 [doi]
AB  - BACKGROUND: Using long-term data from the Korean Genome and Epidemiology Study, 
      we defined poor glycemic control and investigated possible risk factors, 
      including variants related to type 2 diabetes mellitus (T2DM). In addition, we 
      evaluated interaction effects among risk factors for poor glycemic control. 
      METHODS: Among 436 subjects with newly diagnosed diabetes, poor glycemic control 
      was defined based on glycosylated hemoglobin trajectory patterns by group-based 
      trajectory modeling. For the variants related to T2DM, genetic risk scores (GRSs) 
      were calculated and divided into quartiles. Risk factors for poor glycemic 
      control were assessed using a logistic regression model. RESULTS: Of the 
      subjects, 43% were in the poor-glycemic-control group. Body mass index (BMI) and 
      triglyceride (TG) were associated with poor glycemic control. The risk for poor 
      glycemic control increased by 11.0% per 1 kg/m2 increase in BMI and by 3.0% per 
      10 mg/dL increase in TG. The risk for GRS with poor glycemic control was 
      sex-dependent (Pinteraction=0.07), and a relationship by GRS quartiles was found 
      in females but not in males. Moreover, the interaction effect was found to be 
      significant on both additive and multiplicative scales. The interaction effect 
      was evident in the variants of cyclin-dependent kinase 5 regulatory 
      subunit-associated protein 1-like (CDKAL1). CONCLUSION: Females with risk alleles 
      of variants in CDKAL1 associated with T2DM had a higher risk for poor glycemic 
      control than males.
FAU - Lee, Hye Ah
AU  - Lee HA
AD  - Clinical Trial Center, Ewha Womans University Mokdong Hospital, Seoul, Korea.
FAU - Park, Hyesook
AU  - Park H
AD  - Department of Preventive Medicine, Ewha Womans University College of Medicine, 
      Seoul, Korea.
AD  - Graduate Program in System Health Science and Engineering, Ewha Womans 
      University, Seoul, Korea.
FAU - Hong, Young Sun
AU  - Hong YS
AD  - Department of Internal Medicine, Ewha Womans University College of Medicine, 
      Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20220208
PL  - Korea (South)
TA  - Diabetes Metab J
JT  - Diabetes & metabolism journal
JID - 101556588
RN  - 0 (Blood Glucose)
RN  - 0 (Triglycerides)
RN  - EC 2.8.4.5 (CDKAL1 protein, human)
RN  - EC 2.1.1.- (tRNA Methyltransferases)
SB  - IM
MH  - Humans
MH  - Female
MH  - Male
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - Glycemic Control
MH  - Blood Glucose/metabolism
MH  - Sex Characteristics
MH  - *Hyperglycemia
MH  - Triglycerides
MH  - Republic of Korea/epidemiology
MH  - tRNA Methyltransferases/genetics
PMC - PMC9723206
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Gene-environment interaction
OT  - Glycemic control
OT  - Sex characteristics
COIS- CONFLICTS OF INTEREST No potential conflict of interest relevant to this article 
      was reported.
EDAT- 2022/02/09 06:00
MHDA- 2022/12/06 06:00
PMCR- 2022/11/01
CRDT- 2022/02/08 03:13
PHST- 2021/09/29 00:00 [received]
PHST- 2021/11/26 00:00 [accepted]
PHST- 2022/02/09 06:00 [pubmed]
PHST- 2022/12/06 06:00 [medline]
PHST- 2022/02/08 03:13 [entrez]
PHST- 2022/11/01 00:00 [pmc-release]
AID - dmj.2021.0265 [pii]
AID - dmj-2021-0265 [pii]
AID - 10.4093/dmj.2021.0265 [doi]
PST - ppublish
SO  - Diabetes Metab J. 2022 Nov;46(6):879-889. doi: 10.4093/dmj.2021.0265. Epub 2022 
      Feb 8.