PMID- 35131380
OWN - NLM
STAT- MEDLINE
DCOM- 20220419
LR  - 20221207
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 185
DP  - 2022 Mar
TI  - A Cross-Sectional study on risk factors for severe hypoglycemia among 
      Insulin-Treated elderly type 2 diabetes Mellitus (T2DM) patients in Singapore.
PG  - 109236
LID - S0168-8227(22)00048-1 [pii]
LID - 10.1016/j.diabres.2022.109236 [doi]
AB  - OBJECTIVE: This study investigates the risk factors for severe hypoglycemia among 
      Southeast Asian T2DM patients. METHODS: Insulin-treated T2DM patients greater 
      than 65 years old with HbA1c < 8% were recruited. They completed questionnaires 
      detailing their experience of hypoglycemia and presence of impaired hypoglycemia 
      awareness (IAH). Data on insulin treatment regimens, glycated haemoglobin (Hba1c) 
      and comorbidities were also collected. RESULTS: Of the 92 participants, 15.2% had 
      at least one episode of severe hypoglycemia over the past year. Comparison 
      between both groups showed that patients with severe hypoglycemia had lower 
      Hba1c, higher Gold score (3.9 +/- 1.9 vs. 2.5 +/- 1.4; p < .05) and higher 
      Hypoglycemia Fear Survey (HFS) worry score (39.1 +/- 14.3 vs. 31.8 +/- 11.8; 
      p < .05). There were no significant differences in duration of diabetes and 
      insulin treatment, treatment regimens and diabetes associated comorbidities 
      except peripheral vascular disease. Furthermore, no significant differences were 
      noted in HFS behavior score, hypoglycemia risk modifying behavior and social 
      economic status. CONCLUSIONS: Patients with severe hypoglycemia had tighter 
      glycemic control, greater IAH and higher worry scores regardless of treatment 
      regimens. Clinicians may play a significant role in tightening glycemic control 
      and influencing the risk of severe hypoglycemia. Standard structured diabetes 
      education may help reduce the risk of severe hypoglycemia among this group of 
      patients.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Shi Min Ko, Michelle
AU  - Shi Min Ko M
AD  - M.D. Programme, Duke-NUS Medical School, Singapore. Electronic address: 
      michelle.ko.shi.min@u.duke.nus.edu.
FAU - Kit Lee, Wai
AU  - Kit Lee W
AD  - Faculty of Medicine, Nursing, and Health Sciences, Monash University, Melbourne, 
      Australia.
FAU - Chang Ang, Li
AU  - Chang Ang L
AD  - Medicine Academic Clinical Programme, Singapore General Hospital, Singapore.
FAU - Goh, Su-Yen
AU  - Goh SY
AD  - Department of Endocrinology, Singapore General Hospital, Singapore.
FAU - Mong Bee, Yong
AU  - Mong Bee Y
AD  - Department of Endocrinology, Singapore General Hospital, Singapore.
FAU - Ming Teh, Ming
AU  - Ming Teh M
AD  - Department of Endocrinology, Singapore General Hospital, Singapore.
LA  - eng
PT  - Journal Article
DEP - 20220205
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulin)
SB  - IM
MH  - Aged
MH  - Blood Glucose
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/chemically induced/drug therapy
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - *Hypoglycemia/chemically induced/epidemiology
MH  - Hypoglycemic Agents/adverse effects
MH  - Insulin/adverse effects
MH  - Risk Factors
MH  - Singapore/epidemiology
OTO - NOTNLM
OT  - Aged
OT  - Diabetes Mellitus Type 2
OT  - Fear
OT  - Health Behavior
OT  - Hypoglycemia
EDAT- 2022/02/09 06:00
MHDA- 2022/04/20 06:00
CRDT- 2022/02/08 05:41
PHST- 2021/08/16 00:00 [received]
PHST- 2021/12/23 00:00 [revised]
PHST- 2022/01/31 00:00 [accepted]
PHST- 2022/02/09 06:00 [pubmed]
PHST- 2022/04/20 06:00 [medline]
PHST- 2022/02/08 05:41 [entrez]
AID - S0168-8227(22)00048-1 [pii]
AID - 10.1016/j.diabres.2022.109236 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2022 Mar;185:109236. doi: 10.1016/j.diabres.2022.109236. 
      Epub 2022 Feb 5.