PMID- 35131570
OWN - NLM
STAT- MEDLINE
DCOM- 20220406
LR  - 20220406
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 106
DP  - 2022 May
TI  - Lactic acid, a driver of tumor-stroma interactions.
PG  - 108597
LID - S1567-5769(22)00081-9 [pii]
LID - 10.1016/j.intimp.2022.108597 [doi]
AB  - Warburg effect is one of the hallmarks of tumor favoring the suppression of 
      normal oxidative phosphorylation (OxPhos) and the adaptation to hypoxia. In 
      addition to providing continuous energy to meet the demands of tumors, 
      acceleratedWarburg effect also producesa large amount of lactic acid. Lactic acid 
      shuttles between different cell populations within the tumor microenvironment 
      (TME) and confers tumor cells to interact with surrounding cells, which has 
      emerged as a new phenomenon in the field of tumor biology and tumorigenesis. 
      Lactic acid not only fulfills the energetic demands of stromal cells, but becomes 
      a major regulator of their activity by serving as a signaling molecule. Activated 
      stromal cells in turn support tumor development. In this review, we discuss the 
      role of lactic acid in transformation and oncogenic function of stromal cells 
      including fibroblasts, macrophages, adipocytes and vascular endothelial cells, 
      and suggest the relevance of lactic acid in therapy response and essential 
      questions in this field.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Niu, Dun
AU  - Niu D
AD  - Institute of Pharmacy and Pharmacology, University of South China, Hengyang 
      421001, China; Hunan Province Cooperative Innovation Center for Molecular Target 
      New Drug Study, University of South China, Hengyang 421001, China.
FAU - Wu, Yiwen
AU  - Wu Y
AD  - Institute of Pharmacy and Pharmacology, University of South China, Hengyang 
      421001, China; Hunan Province Cooperative Innovation Center for Molecular Target 
      New Drug Study, University of South China, Hengyang 421001, China.
FAU - Lei, Ziyao
AU  - Lei Z
AD  - Institute of Pharmacy and Pharmacology, University of South China, Hengyang 
      421001, China.
FAU - Zhang, Ming
AU  - Zhang M
AD  - Institute of Pharmacy and Pharmacology, University of South China, Hengyang 
      421001, China.
FAU - Xie, Zhizhong
AU  - Xie Z
AD  - Institute of Pharmacy and Pharmacology, University of South China, Hengyang 
      421001, China; Hunan Province Cooperative Innovation Center for Molecular Target 
      New Drug Study, University of South China, Hengyang 421001, China. Electronic 
      address: zhizhongx@126.com.
FAU - Tang, Shengsong
AU  - Tang S
AD  - Hunan Province Key Laboratory for Antibody-based Drug and Intelligent Delivery 
      System, Hunan University of Medicine, Huaihua 418000, China. Electronic address: 
      tangss111@163.com.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220204
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Endothelial Cells
MH  - *Glycolysis
MH  - *Lactic Acid
MH  - Oxidative Phosphorylation
MH  - Stromal Cells
MH  - Tumor Microenvironment
OTO - NOTNLM
OT  - Lactic acid
OT  - Tumor-associated adipocytes
OT  - Tumor-associated fibroblasts
OT  - Tumor-associated macrophages
OT  - Tumor-associated vascular endothelial cells
EDAT- 2022/02/09 06:00
MHDA- 2022/04/07 06:00
CRDT- 2022/02/08 05:43
PHST- 2021/12/20 00:00 [received]
PHST- 2022/01/23 00:00 [revised]
PHST- 2022/01/27 00:00 [accepted]
PHST- 2022/02/09 06:00 [pubmed]
PHST- 2022/04/07 06:00 [medline]
PHST- 2022/02/08 05:43 [entrez]
AID - S1567-5769(22)00081-9 [pii]
AID - 10.1016/j.intimp.2022.108597 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2022 May;106:108597. doi: 10.1016/j.intimp.2022.108597. Epub 
      2022 Feb 4.