PMID- 35131814
OWN - NLM
STAT- MEDLINE
DCOM- 20220322
LR  - 20220531
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 12
IP  - 2
DP  - 2022 Feb 7
TI  - Determinants of HIV infection among children born from mothers on prevention of 
      mother to child transmission programme of HIV in southern Ethiopia: a 
      case-control study.
PG  - e048491
LID - 10.1136/bmjopen-2020-048491 [doi]
LID - e048491
AB  - OBJECTIVE: This study was aimed to identify determinants of HIV infection among 
      children born from mothers on the prevention of mother to child transmission 
      (PMTCT) programme in Southern Ethiopia. It was designed to explore the main 
      contributors to the considerable transmission rate of HIV from mother to child. 
      SETTING AND DESIGN: A multicentre facility-based unmatched case-control study was 
      conducted using 27 health facilities providing PMTCT service in Southern 
      Ethiopia. PARTICIPANTS: Out of 307 (62 cases and 245 controls) expected to 
      participate in this study, a total of 290 mother-child pairs of 58 cases and 232 
      controls have completed the interview. Cases were children born to mothers on 
      PMTCT programme and with DNA PCR or antibody HIV positive test result at </=24 
      months of age. Controls were children born to mothers on PMTCT programme and with 
      DNA PCR or antibody HIV negative test result at </=24 months of age. RESULT: Data 
      were collected from the mother and record and analysed using SPSS V.20. Logistic 
      regression analysis was done for statistical association and the significance of 
      association was declared at a p value of <0.05. Rural residence (adjusted OR 
      (AOR): 4.15, 95% CI: (1.57 to 10.97)), knowing serostatus during current 
      pregnancy (AOR: 5.11, 95% CI: (1.33 to 19.69)), home delivery (AOR: 6.00, 95% CI: 
      (2.310 to 15.593)), poor partner involvement (AOR: 5.95, 95% CI: 1.91 to 18.53)), 
      poor adherence, late enrolment of the child for ARV prophylaxis (AOR: 4.89, 
      95% CI: 1.34 to 17.88)), mixed breastfeeding practice (AOR: 10.36, 95% CI: (3.10 
      to 34.60)) and failure to be on cotrimoxazole therapy (AOR: 7.56, 95% CI: 2.07 to 
      27.61)) were factors significantly associated with MTCT. CONCLUSION: The finding 
      implies that more needs to be done on rural residents, strengthening screening 
      for HIV before pregnancy, encouraging male involvement, early enrolment of child 
      for ARV prophylaxis, avoiding mixed breast feeding and putting newborn on 
      cotrimoxazole therapy.
CI  - (c) Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Hussen, Rehima
AU  - Hussen R
AD  - School of Public Health, Dilla University College of Health Sciences, Dilla, 
      Ethiopia.
FAU - Zenebe, Wagaye Alemu
AU  - Zenebe WA
AD  - School of Public Health, Dilla University College of Health Sciences, Dilla, 
      Ethiopia.
FAU - Mamo, Tizalegn Tesfaye
AU  - Mamo TT
AD  - School of Public Health, Dilla University College of Health Sciences, Dilla, 
      Ethiopia.
FAU - Shaka, Mohammed Feyisso
AU  - Shaka MF
AUID- ORCID: 0000-0001-9352-058X
AD  - School of Public Health, Dilla University College of Health Sciences, Dilla, 
      Ethiopia mamfys8@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20220207
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
MH  - Case-Control Studies
MH  - Ethiopia/epidemiology
MH  - Female
MH  - *HIV Infections/drug therapy
MH  - *HIV-1
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Infectious Disease Transmission, Vertical/prevention & control
MH  - Male
MH  - Mothers
MH  - Pregnancy
MH  - *Pregnancy Complications, Infectious/drug therapy/prevention & control
PMC - PMC8823216
OTO - NOTNLM
OT  - HIV & AIDS
OT  - community child health
OT  - infectious diseases
COIS- Competing interests: None declared.
EDAT- 2022/02/09 06:00
MHDA- 2022/03/23 06:00
PMCR- 2022/02/07
CRDT- 2022/02/08 05:48
PHST- 2022/02/08 05:48 [entrez]
PHST- 2022/02/09 06:00 [pubmed]
PHST- 2022/03/23 06:00 [medline]
PHST- 2022/02/07 00:00 [pmc-release]
AID - bmjopen-2020-048491 [pii]
AID - 10.1136/bmjopen-2020-048491 [doi]
PST - epublish
SO  - BMJ Open. 2022 Feb 7;12(2):e048491. doi: 10.1136/bmjopen-2020-048491.