PMID- 35133397
OWN - NLM
STAT- MEDLINE
DCOM- 20220422
LR  - 20220610
IS  - 1939-327X (Electronic)
IS  - 0012-1797 (Linking)
VI  - 71
IP  - 5
DP  - 2022 May 1
TI  - Alteration of the Individual Metabolic Network of the Brain Based on 
      Jensen-Shannon Divergence Similarity Estimation in Elderly Patients With Type 2 
      Diabetes Mellitus.
PG  - 894-905
LID - 10.2337/db21-0600 [doi]
AB  - The aim of this study was to investigate the interactive effect between aging and 
      type 2 diabetes mellitus (T2DM) on brain glucose metabolism, individual metabolic 
      connectivity, and network properties. Using a 2 x 2 factorial design, 83 patients 
      with T2DM (40 elderly and 43 middle-aged) and 69 sex-matched healthy control 
      subjects (HCs) (34 elderly and 35 middle-aged) underwent 18F-fluorodeoxyglucose 
      positron emission tomography/magnetic resonance scanning. Jensen-Shannon 
      divergence was applied to construct individual metabolic connectivity and 
      networks. The topological properties of the networks were quantified using graph 
      theoretical analysis. The general linear model was used to mainly estimate the 
      interaction effect between aging and T2DM on glucose metabolism, metabolic 
      connectivity, and network. There was an interaction effect between aging and T2DM 
      on glucose metabolism, metabolic connectivity, and regional metabolic network 
      properties (all P < 0.05). The post hoc analyses showed that compared with 
      elderly HCs and middle-aged patients with T2DM, elderly patients with T2DM had 
      decreased glucose metabolism, increased metabolic connectivity, and regional 
      metabolic network properties in cognition-related brain regions (all P < 0.05). 
      Age and fasting plasma glucose had negative correlations with glucose metabolism 
      and positive correlations with metabolic connectivity. Elderly patients with T2DM 
      had glucose hypometabolism, strengthened functional integration, and increased 
      efficiency of information communication mainly located in cognition-related brain 
      regions. Metabolic connectivity pattern changes might be compensatory changes for 
      glucose hypometabolism.
CI  - (c) 2022 by the American Diabetes Association.
FAU - Li, Yu-Lin
AU  - Li YL
AD  - School of Rehabilitation Science, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
FAU - Wu, Jia-Jia
AU  - Wu JJ
AD  - Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional 
      Chinese and Western Medicine, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
FAU - Ma, Jie
AU  - Ma J
AD  - School of Rehabilitation Science, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
FAU - Li, Si-Si
AU  - Li SS
AD  - School of Rehabilitation Science, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
FAU - Xue, Xin
AU  - Xue X
AD  - School of Rehabilitation Science, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
FAU - Wei, Dong
AU  - Wei D
AD  - School of Rehabilitation Science, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
FAU - Shan, Chun-Lei
AU  - Shan CL
AD  - School of Rehabilitation Science, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
AD  - Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional 
      Chinese and Western Medicine, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
AD  - Engineering Research Center of Traditional Chinese Medicine Intelligent 
      Rehabilitation, Ministry of Education, Shanghai, China.
FAU - Hua, Xu-Yun
AU  - Hua XY
AUID- ORCID: 0000-0002-2935-7551
AD  - Department of Traumatology and Orthopedics, Yueyang Hospital of Integrated 
      Traditional Chinese and Western Medicine, Shanghai University of Traditional 
      Chinese Medicine, Shanghai, China.
FAU - Zheng, Mou-Xiong
AU  - Zheng MX
AUID- ORCID: 0000-0002-9861-6086
AD  - Department of Traumatology and Orthopedics, Yueyang Hospital of Integrated 
      Traditional Chinese and Western Medicine, Shanghai University of Traditional 
      Chinese Medicine, Shanghai, China.
FAU - Xu, Jian-Guang
AU  - Xu JG
AUID- ORCID: 0000-0003-0601-3403
AD  - School of Rehabilitation Science, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
AD  - Department of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional 
      Chinese and Western Medicine, Shanghai University of Traditional Chinese 
      Medicine, Shanghai, China.
LA  - eng
SI  - figshare/10.2337/figshare.19122653
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Diabetes
JT  - Diabetes
JID - 0372763
RN  - 0Z5B2CJX4D (Fluorodeoxyglucose F18)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Aged
MH  - Brain/metabolism
MH  - *Diabetes Mellitus, Type 2/metabolism
MH  - Fluorodeoxyglucose F18/metabolism
MH  - Glucose/metabolism
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Metabolic Networks and Pathways
MH  - Middle Aged
MH  - Positron-Emission Tomography
EDAT- 2022/02/09 06:00
MHDA- 2022/04/23 06:00
CRDT- 2022/02/08 12:15
PHST- 2021/07/04 00:00 [received]
PHST- 2022/02/03 00:00 [accepted]
PHST- 2022/02/09 06:00 [pubmed]
PHST- 2022/04/23 06:00 [medline]
PHST- 2022/02/08 12:15 [entrez]
AID - 144535 [pii]
AID - 10.2337/db21-0600 [doi]
PST - ppublish
SO  - Diabetes. 2022 May 1;71(5):894-905. doi: 10.2337/db21-0600.