PMID- 35133495 OWN - NLM STAT- MEDLINE DCOM- 20220303 LR - 20220304 IS - 1432-1963 (Electronic) IS - 0172-8113 (Print) IS - 0172-8113 (Linking) VI - 43 IP - 2 DP - 2022 Mar TI - [Diagnostic and predictive markers in urinary tract cytology]. PG - 99-104 LID - 10.1007/s00292-022-01053-9 [doi] AB - Multiprobe fluorescence in situ hybridization (FISH) still remains the gold standard for clarifying inconclusive atypia in urinary cytology in daily routine practice. The Paris Classification System (The Paris System, TPS) provides an important basis for the specific indication of FISH and emphasizes the importance of morphological correlation for an integrative approach to diagnosis. Next-generation sequencing technology in urinary specimens, which is highly sensitive for simultaneous detection of multiple genetic alterations, is also likely to play a diagnostic role in the near future. CI - (c) 2022. The Author(s). FAU - Vlajnic, Tatjana AU - Vlajnic T AD - Pathologie, Institut fur medizinische Genetik und Pathologie, Universitatsspital Basel, Schonbeinstr. 40, 4031, Basel, Schweiz. Tatjana.Vlajnic@usb.ch. FAU - Bubendorf, Lukas AU - Bubendorf L AD - Pathologie, Institut fur medizinische Genetik und Pathologie, Universitatsspital Basel, Schonbeinstr. 40, 4031, Basel, Schweiz. LA - ger PT - Journal Article PT - Review TT - Diagnostische und pradiktive Marker in der Harntraktzytologie. DEP - 20220208 PL - Germany TA - Pathologe JT - Der Pathologe JID - 8006541 RN - 0 (Biomarkers) SB - IM MH - Biomarkers MH - Cytodiagnosis MH - Humans MH - In Situ Hybridization, Fluorescence MH - *Urinary Tract/pathology MH - *Urologic Neoplasms/pathology PMC - PMC8888376 OTO - NOTNLM OT - Differential diagnosis OT - High-throughput nucleotide sequencing OT - Immune checkpoint inhibitors OT - Immunohistochemistry OT - Urologic neoplasms EDAT- 2022/02/09 06:00 MHDA- 2022/03/04 06:00 PMCR- 2022/02/08 CRDT- 2022/02/08 12:15 PHST- 2022/01/02 00:00 [accepted] PHST- 2022/02/09 06:00 [pubmed] PHST- 2022/03/04 06:00 [medline] PHST- 2022/02/08 12:15 [entrez] PHST- 2022/02/08 00:00 [pmc-release] AID - 10.1007/s00292-022-01053-9 [pii] AID - 1053 [pii] AID - 10.1007/s00292-022-01053-9 [doi] PST - ppublish SO - Pathologe. 2022 Mar;43(2):99-104. doi: 10.1007/s00292-022-01053-9. Epub 2022 Feb 8.