PMID- 35135919
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20221006
IS  - 1349-7235 (Electronic)
IS  - 0918-2918 (Print)
IS  - 0918-2918 (Linking)
VI  - 61
IP  - 17
DP  - 2022 Sep 1
TI  - The First Case of Gastric Neuroendocrine Tumors Induced by a Proton Pump 
      Inhibitor in von Hippel-Lindau Disease.
PG  - 2587-2592
LID - 10.2169/internalmedicine.8701-21 [doi]
AB  - Von Hippel-Lindau (VHL) disease is a rare inherited familial syndrome complicated 
      with various neoplasms, including neuroendocrine tumors (NETs). We herein report 
      the first case of multiple gastric NETs in a 45-year-old man with VHL. He had 
      multiple gastric polyps, and several endoscopic resected lesions were diagnosed 
      as NETs. The serum gastrin level was elevated because he was taking a proton pump 
      inhibitor (PPI). We suspected that gastrin had played a role in the development 
      of NETs, and the remaining polyps were followed up with discontinuation of the 
      PPI. The NETs gradually reduced in size until they became hard to notice on 
      endoscopy and have remained nearly invisible for over eight years.
FAU - Kawaguchi, Koichiro
AU  - Kawaguchi K
AD  - Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori 
      University, Japan.
FAU - Yashima, Kazuo
AU  - Yashima K
AD  - Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori 
      University, Japan.
FAU - Ikebuchi, Yuichiro
AU  - Ikebuchi Y
AD  - Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori 
      University, Japan.
FAU - Yoshida, Akira
AU  - Yoshida A
AD  - Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori 
      University, Japan.
FAU - Kuwamoto, Satoshi
AU  - Kuwamoto S
AD  - Department of Pathology, Faculty of Medicine, Tottori University, Japan.
FAU - Isomoto, Hajime
AU  - Isomoto H
AD  - Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori 
      University, Japan.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20220208
PL  - Japan
TA  - Intern Med
JT  - Internal medicine (Tokyo, Japan)
JID - 9204241
RN  - 0 (Gastrins)
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Gastrins
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Neuroendocrine Tumors/complications/diagnosis/drug therapy
MH  - Proton Pump Inhibitors/adverse effects
MH  - *Stomach Neoplasms/complications/drug therapy
MH  - *von Hippel-Lindau Disease/complications
PMC - PMC9492478
OTO - NOTNLM
OT  - gastrin
OT  - neuroendocrine tumor (NET)
OT  - proton pump inhibitor (PPI)
OT  - von Hippel-Lindau disease (VHL)
COIS- The authors state that they have no Conflict of Interest (COI).
EDAT- 2022/02/10 06:00
MHDA- 2022/09/09 06:00
PMCR- 2022/09/01
CRDT- 2022/02/09 05:42
PHST- 2022/02/10 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/02/09 05:42 [entrez]
PHST- 2022/09/01 00:00 [pmc-release]
AID - 10.2169/internalmedicine.8701-21 [doi]
PST - ppublish
SO  - Intern Med. 2022 Sep 1;61(17):2587-2592. doi: 10.2169/internalmedicine.8701-21. 
      Epub 2022 Feb 8.