PMID- 35136100
OWN - NLM
STAT- MEDLINE
DCOM- 20220315
LR  - 20221024
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Feb 8
TI  - Thoracolumbar epidural stimulation effects on bladder and bowel function in 
      uninjured and chronic transected anesthetized rats.
PG  - 2137
LID - 10.1038/s41598-022-06011-2 [doi]
LID - 2137
AB  - Pre-clinical studies have shown that spinal cord epidural stimulation (scES) at 
      the level of pelvic and pudendal nerve inputs/outputs (L5-S1) alters storage 
      and/or emptying functions of both the bladder and bowel. The current mapping 
      experiments were conducted to investigate scES efficacy at the level of 
      hypogastric nerve inputs/outputs (T13-L2) in male and female rats under urethane 
      anesthesia. As found with L5-S1 scES, T13-L2 scES at select frequencies and 
      intensities of stimulation produced an increase in inter-contraction interval 
      (ICI) in non-injured female rats but a short-latency void in chronic T9 
      transected rats, as well as reduced rectal activity in all groups. However, the 
      detrusor pressure during the lengthened ICI (i.e., urinary hold) remained at a 
      low pressure and was not elevated as seen with L5-S1 scES, an effect that's 
      critical for translation to the clinic as high fill pressures can damage the 
      kidneys. Furthermore, T13-L2 scES was shown to stimulate voiding post-transection 
      by increasing bladder activity while also directly inhibiting the external 
      urethral sphincter, a pattern necessary to overcome detrusor-sphincter 
      dyssynergia. Additionally, select scES parameters at T13-L2 also increased distal 
      colon activity in all groups. Together, the current findings suggest that 
      optimization of scES for bladder and bowel will likely require multiple electrode 
      cohorts at different locations that target circuitries coordinating sympathetic, 
      parasympathetic and somatic outputs.
CI  - (c) 2022. The Author(s).
FAU - Hoey, Robert F
AU  - Hoey RF
AD  - Department of Anatomical Sciences and Neurobiology, University of Louisville 
      School of Medicine, Louisville, KY, USA.
AD  - Physical Medicine and Rehabilitation Department, MetroHealth Rehabilitation 
      Institute of Ohio, Cleveland, OH, USA.
FAU - Medina-Aguinaga, Daniel
AU  - Medina-Aguinaga D
AD  - Department of Anatomical Sciences and Neurobiology, University of Louisville 
      School of Medicine, Louisville, KY, USA.
FAU - Khalifa, Fahmi
AU  - Khalifa F
AD  - Bioengineering Department, University of Louisville J. B. Speed School of 
      Engineering, Louisville, KY, USA.
FAU - Ugiliweneza, Beatrice
AU  - Ugiliweneza B
AD  - Department of Neurological Surgery, University of Louisville School of Medicine, 
      Louisville, KY, USA.
AD  - Kentucky Spinal Cord Injury Research Center, University of Louisville, 
      Louisville, KY, USA.
AD  - Department of Health Management and Systems Science, School of Public Health and 
      Information Science, University of Louisville, Louisville, KY, USA.
FAU - Wang, Dengzhi
AU  - Wang D
AD  - Department of Neurological Surgery, University of Louisville School of Medicine, 
      Louisville, KY, USA.
AD  - Kentucky Spinal Cord Injury Research Center, University of Louisville, 
      Louisville, KY, USA.
FAU - Zdunowski, Sharon
AU  - Zdunowski S
AD  - Kentucky Spinal Cord Injury Research Center, University of Louisville, 
      Louisville, KY, USA.
FAU - Fell, Jason
AU  - Fell J
AD  - Department of Anatomical Sciences and Neurobiology, University of Louisville 
      School of Medicine, Louisville, KY, USA.
FAU - Naglah, Ahmed
AU  - Naglah A
AD  - Bioengineering Department, University of Louisville J. B. Speed School of 
      Engineering, Louisville, KY, USA.
FAU - El-Baz, Ayman S
AU  - El-Baz AS
AD  - Bioengineering Department, University of Louisville J. B. Speed School of 
      Engineering, Louisville, KY, USA.
FAU - Herrity, April N
AU  - Herrity AN
AD  - Department of Neurological Surgery, University of Louisville School of Medicine, 
      Louisville, KY, USA.
AD  - Kentucky Spinal Cord Injury Research Center, University of Louisville, 
      Louisville, KY, USA.
FAU - Harkema, Susan J
AU  - Harkema SJ
AD  - Department of Neurological Surgery, University of Louisville School of Medicine, 
      Louisville, KY, USA.
AD  - Kentucky Spinal Cord Injury Research Center, University of Louisville, 
      Louisville, KY, USA.
FAU - Hubscher, Charles H
AU  - Hubscher CH
AD  - Department of Anatomical Sciences and Neurobiology, University of Louisville 
      School of Medicine, Louisville, KY, USA. chhubs01@louisville.edu.
AD  - Kentucky Spinal Cord Injury Research Center, University of Louisville, 
      Louisville, KY, USA. chhubs01@louisville.edu.
LA  - eng
GR  - OT2 OD024898/OD/NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20220208
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Animals
MH  - Electric Stimulation Therapy/*methods
MH  - Electromyography
MH  - Female
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Rectal Diseases/etiology/*therapy
MH  - Spinal Cord Injuries/*complications
MH  - Urination Disorders/etiology/*therapy
PMC - PMC8826941
COIS- The authors declare no competing interests.
EDAT- 2022/02/10 06:00
MHDA- 2022/03/16 06:00
PMCR- 2022/02/08
CRDT- 2022/02/09 05:43
PHST- 2021/09/17 00:00 [received]
PHST- 2022/01/18 00:00 [accepted]
PHST- 2022/02/09 05:43 [entrez]
PHST- 2022/02/10 06:00 [pubmed]
PHST- 2022/03/16 06:00 [medline]
PHST- 2022/02/08 00:00 [pmc-release]
AID - 10.1038/s41598-022-06011-2 [pii]
AID - 6011 [pii]
AID - 10.1038/s41598-022-06011-2 [doi]
PST - epublish
SO  - Sci Rep. 2022 Feb 8;12(1):2137. doi: 10.1038/s41598-022-06011-2.