PMID- 35136584
OWN - NLM
STAT- MEDLINE
DCOM- 20220214
LR  - 20220214
IS  - 2046-1402 (Electronic)
IS  - 2046-1402 (Linking)
VI  - 10
DP  - 2021
TI  - Inflammatory laboratory findings associated with severe illness among 
      hospitalized individuals with COVID-19 in Medan, Indonesia: a cross-sectional 
      study.
PG  - 1246
LID - 10.12688/f1000research.74758.2 [doi]
AB  - Background: Coronavirus disease (COVID-19) remains a global health problem. 
      COVID-19 patients with severe pneumonia have a higher risk for critical illness, 
      mostly complicated by acute respiratory distress syndrome. The inflammatory 
      response is critical, and the cytokine storm increases the severity of COVID-19. 
      Many factors could be associated with a cytokine storm but they are incompletely 
      understood. This study presents characteristics of COVID-19 patients and explore 
      the clinical and inflammatory parameters of severe and critically ill COVID-19 
      patients in the intensive care unit (ICU). Method: This cross-sectional study was 
      conducted in all severe COVID-19 patients admitted to the ICU. Peripheral blood 
      was taken for laboratory examination within 24 hours of admission. Haematologic 
      parameters, serum electrolyte, renal function, liver function, pancreas enzyme, 
      D-dimer, inflammatory cytokines interferon (IFN)-gamma, tumour necrosis factor 
      (TNF)-alpha, interleukin (IL)-6, IL-10, monocyte chemoattractant protein-1 
      (MCP-1), and C-reactive protein (CRP) were assessed in this study. Comparative 
      analyses were done between sex, existing comorbidities, body mass index (BMI), 
      and COVID-19 vaccination status. Results: A total of 80 subjects were included in 
      the study. The most frequent comorbidities found among the subjects were obesity 
      (36.35%) and diabetes (22.5%). Only 13.75% of subjects were vaccinated. 
      Laboratory results indicated leucocytosis and neutrophilia, with a 
      neutrophil-lymphocyte-ratio (NLR) of 7. The mean inflammatory findings (IL-6, 
      IL-10, TNF-alpha, IFN-gamma, MCP-1), D-dimer, CRP, and lipase increased. Lipase 
      levels were higher in men (p = 0.003) and in comorbidity groups. No significant 
      differences were found among different BMI groups. Lipase, IL-6, and MCP-1 levels 
      were significantly higher (p=0.019, <0.0001, and 0.03, respectively) in the 
      non-vaccinated group. Conclusions: Most patients with severe COVID-19 have 
      comorbidities and increased inflammatory markers.
CI  - Copyright: (c) 2022 Darmadi D et al.
FAU - Darmadi, Darmadi
AU  - Darmadi D
AUID- ORCID: 0000-0001-5281-168X
AD  - Department of Internal Medicine, Faculty of Medicine, Universitas Sumatera Utara, 
      Medan, North Sumatera, Indonesia.
FAU - Pakpahan, Cennikon
AU  - Pakpahan C
AUID- ORCID: 0000-0003-0157-1131
AD  - Andrology Study Program, Department of Biomedical Sciences, Faculty of Medicine, 
      Universitas Airlangga, Surabaya, East Java, Indonesia.
FAU - Ruslie, Riska Habriel
AU  - Ruslie RH
AUID- ORCID: 0000-0001-7779-6535
AD  - Department of Child Health, Faculty of Medicine, Universitas Prima Indonesia, 
      Medan, North Sumatera, Indonesia.
FAU - Rezano, Andri
AU  - Rezano A
AUID- ORCID: 0000-0003-2550-8794
AD  - Andrology Study Program, Department of Biomedical Sciences, Faculty of Medicine, 
      Universitas Airlangga, Surabaya, East Java, Indonesia.
AD  - Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, 
      Sumedang, West Java, Indonesia.
LA  - eng
SI  - figshare/10.6084/m9.figshare.18027170
PT  - Journal Article
DEP - 20211206
PL  - England
TA  - F1000Res
JT  - F1000Research
JID - 101594320
RN  - 0 (COVID-19 Vaccines)
SB  - IM
MH  - *COVID-19
MH  - COVID-19 Vaccines
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Indonesia/epidemiology
MH  - Laboratories
MH  - Male
MH  - SARS-CoV-2
PMC - PMC8792878
OTO - NOTNLM
OT  - COVID-19
OT  - comorbid
OT  - cytokine
OT  - good health
OT  - inflammatory
OT  - vaccination
OT  - well-being
COIS- No competing interests were disclosed.
EDAT- 2022/02/11 06:00
MHDA- 2022/02/15 06:00
CRDT- 2022/02/10 05:36
PHST- 2022/01/10 00:00 [accepted]
PHST- 2022/02/10 05:36 [entrez]
PHST- 2022/02/11 06:00 [pubmed]
PHST- 2022/02/15 06:00 [medline]
AID - 10.12688/f1000research.74758.2 [doi]
PST - epublish
SO  - F1000Res. 2021 Dec 6;10:1246. doi: 10.12688/f1000research.74758.2. eCollection 
      2021.