PMID- 35137463
OWN - NLM
STAT- MEDLINE
DCOM- 20220413
LR  - 20220413
IS  - 1440-1789 (Electronic)
IS  - 0919-6544 (Linking)
VI  - 42
IP  - 2
DP  - 2022 Apr
TI  - Mixed gangliocytoma-pituitary adenoma in MEN1 syndrome: A case report and 
      literature review.
PG  - 155-159
LID - 10.1111/neup.12788 [doi]
AB  - Pituitary adenoma is one of the three most common neoplasms described in multiple 
      endocrine neoplasia type 1 (MEN1), and patients with pituitary adenoma occupies 
      30-50% of those with MEN1-related tumor. Mixed gangliocytoma-pituitary adenoma 
      (MGPA) is a rare clinical entity in which gangliomatous cells are intermixed with 
      adenomatous cells. This tumor has been estimated to account for 0.52-1.26% of all 
      pituitary tumors. We report a rare case of MGPA in a patient with MEN1. A 
      retrospective chart review was conducted on a patient with MEN1 diagnosed with 
      MGPA in 2019 at a single tertiary academic medical center. A review of the 
      literature was performed on MGPA and pituitary adenoma in MEN1. MGPA is rare, 
      with only 174 cases previously reported in the literature and only three prior 
      case reported in a patient with MEN1. There are multiple hypotheses regarding 
      their pathogenesis, and it is unclear whether the MEN1 gene (menin) plays a role 
      in the pathogenesis of MGPA. This tumor in MEN1 is a rare clinical entity of 
      unknown etiology. Further studies are required with difficulty due to its low 
      incidence.
CI  - (c) 2022 Japanese Society of Neuropathology.
FAU - Martin, Elaine C
AU  - Martin EC
AD  - Department of Otolaryngology - Head & Neck Surgery, University of California 
      Irvine Medical Center, Orange, California, USA.
FAU - Bitner, Benjamin F
AU  - Bitner BF
AUID- ORCID: 0000-0002-9869-8114
AD  - Department of Otolaryngology - Head & Neck Surgery, University of California 
      Irvine Medical Center, Orange, California, USA.
FAU - Perez-Rosendahl, Mari
AU  - Perez-Rosendahl M
AD  - Department of Pathology and Laboratory Medicine, University of California Irvine 
      Medical Center, Orange, California, USA.
FAU - Kuan, Edward C
AU  - Kuan EC
AD  - Department of Otolaryngology - Head & Neck Surgery, University of California 
      Irvine Medical Center, Orange, California, USA.
AD  - Department of Neurological Surgery, University of California Irvine Medical 
      Center, Orange, California, USA.
FAU - Linskey, Mark E
AU  - Linskey ME
AD  - Department of Neurological Surgery, University of California Irvine Medical 
      Center, Orange, California, USA.
LA  - eng
PT  - Case Reports
PT  - Review
DEP - 20220208
PL  - Australia
TA  - Neuropathology
JT  - Neuropathology : official journal of the Japanese Society of Neuropathology
JID - 9606526
SB  - IM
MH  - *Adenoma/complications/diagnosis
MH  - *Ganglioneuroma/complications/pathology
MH  - Humans
MH  - *Multiple Endocrine Neoplasia Type 1/complications/diagnosis/genetics
MH  - *Pituitary Neoplasms/genetics
MH  - Retrospective Studies
OTO - NOTNLM
OT  - MEN1
OT  - endoscopic pituitary surgery
OT  - gangliocytoma
OT  - pituitary adenoma
OT  - pituitary neoplasms
EDAT- 2022/02/10 06:00
MHDA- 2022/04/14 06:00
CRDT- 2022/02/09 06:03
PHST- 2021/10/18 00:00 [revised]
PHST- 2021/09/07 00:00 [received]
PHST- 2021/10/25 00:00 [accepted]
PHST- 2022/02/10 06:00 [pubmed]
PHST- 2022/04/14 06:00 [medline]
PHST- 2022/02/09 06:03 [entrez]
AID - 10.1111/neup.12788 [doi]
PST - ppublish
SO  - Neuropathology. 2022 Apr;42(2):155-159. doi: 10.1111/neup.12788. Epub 2022 Feb 8.