PMID- 35137999
OWN - NLM
STAT- MEDLINE
DCOM- 20220331
LR  - 20220401
IS  - 1469-445X (Electronic)
IS  - 0958-0670 (Linking)
VI  - 107
IP  - 3
DP  - 2022 Mar
TI  - GABA-ergic agents modulated the effects of histamine on the behaviour of male 
      mice in the elevated plus maze test.
PG  - 233-242
LID - 10.1113/EP090060 [doi]
AB  - NEW FINDINGS: What is the central question of this study? Is there an interaction 
      between histamine and the GABAergic system in modulation of anxiety in mice? What 
      is the main finding and its importance? There is a synergistic anxiogenic effect 
      between histamine and bicuculline in mice. This effect may be due to a direct or 
      an indirect effect of the histaminergic system on the GABAergic system. ABSTRACT: 
      It has been documented that both histaminergic and GABAergic systems participate 
      in the neurobiology of anxiety behaviour. In the current research, we 
      investigated the effects of the histaminergic system and GABA(A) receptor agents 
      on anxiety-related behaviours and their interaction using the elevated plus maze 
      test in mice. Intraperitoneal (i.p.) administration of muscimol (0.12 and 
      0.25 mg/kg) increased the open arm time (OAT) (P < 0.001) without affecting the 
      open arm entries (OAE) and locomotor activity, showing an anxiolytic effect. i.p. 
      injection of bicuculline (0.5 and 1 mg/kg) decreased OAT (P < 0.001) but not OAE 
      and locomotor activity, suggesting an anxiogenic behaviour. 
      Intracerebroventricular (i.c.v.) microinjection of histamine (2.5 and 5 mug/mouse) 
      resulted in a decline in OAT (P < 0.001) but not OAE and locomotor activity, 
      indicating an anxiogenic response. Co-administration of histamine with GABAergic 
      agents, muscimol (0.06 mg/kg; i.p.) and bicuculline (0.25 mg/kg; i.p.), decreased 
      (P < 0.001) and increased (P < 0.05), respectively, the anxiogenic-like response 
      to the effective dose (5 mug/mouse; i.c.v.) of histamine. In addition, 
      co-treatment of effective doses of histamine (2.5 and 5 mug/mouse;i.c.v.) with an 
      effective dose of muscimol (0.12 mg/kg; i.p.) and a non-effective dose of 
      bicuculline (0.25 mg/kg; i.p.) significantly decreased OAT (P < 0.001), 
      suggesting a likely interaction between the histaminergic and GABAergic systems 
      in the regulation of anxiety. The results demonstrated a synergistic 
      anxiogenic-like effect between histamine and bicuculline in mice. In conclusion, 
      our results present an interaction between the histaminergic and GABAergic 
      systems in anxiolytic/anxiogenic-like behaviours in the elevated plus maze test.
CI  - (c) 2022 The Authors. Experimental Physiology (c) 2022 The Physiological Society.
FAU - Fathalizade, Farzan
AU  - Fathalizade F
AD  - Department of Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic 
      Azad University, Tehran, Iran.
AD  - Department of Pharmacology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Baghani, Matin
AU  - Baghani M
AD  - Department of Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic 
      Azad University, Tehran, Iran.
AD  - Department of Pharmacology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Khakpai, Fatemeh
AU  - Khakpai F
AUID- ORCID: 0000-0001-7395-9974
AD  - Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, 
      Islamic Azad University, Tehran, Iran.
FAU - Fazli-Tabaei, Soheila
AU  - Fazli-Tabaei S
AD  - Department of Physiology, Faculty of Medicine, Tehran Medical Sciences, Islamic 
      Azad University, Tehran, Iran.
FAU - Zarrindast, Mohammad-Reza
AU  - Zarrindast MR
AUID- ORCID: 0000-0002-0688-5378
AD  - Department of Pharmacology, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran.
AD  - Iranian National Center for Addiction Studies, Tehran University of Medical 
      Sciences, Tehran, Iran.
AD  - Department of Neuroendocrinology, Endocrinology and Metabolism Clinical Sciences 
      Institute, Tehran University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220223
PL  - England
TA  - Exp Physiol
JT  - Experimental physiology
JID - 9002940
RN  - 0 (GABA Agents)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Animals
MH  - Anxiety/drug therapy
MH  - *Elevated Plus Maze Test
MH  - GABA Agents/pharmacology
MH  - *Histamine/pharmacology
MH  - Male
MH  - Maze Learning
MH  - Mice
MH  - Rats
MH  - Rats, Wistar
MH  - gamma-Aminobutyric Acid/pharmacology/physiology
OTO - NOTNLM
OT  - anxiety
OT  - bicuculline
OT  - histamine
OT  - left ventricle
OT  - mice
OT  - muscimol
EDAT- 2022/02/10 06:00
MHDA- 2022/04/01 06:00
CRDT- 2022/02/09 08:44
PHST- 2021/09/13 00:00 [received]
PHST- 2022/01/28 00:00 [accepted]
PHST- 2022/02/10 06:00 [pubmed]
PHST- 2022/04/01 06:00 [medline]
PHST- 2022/02/09 08:44 [entrez]
AID - 10.1113/EP090060 [doi]
PST - ppublish
SO  - Exp Physiol. 2022 Mar;107(3):233-242. doi: 10.1113/EP090060. Epub 2022 Feb 23.