PMID- 35138368 OWN - NLM STAT- MEDLINE DCOM- 20221214 LR - 20230228 IS - 2058-1742 (Electronic) IS - 2058-5225 (Print) IS - 2058-1742 (Linking) VI - 9 IP - 1 DP - 2022 Dec 13 TI - Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry. PG - 42-53 LID - 10.1093/ehjqcco/qcac006 [doi] AB - AIMS: The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry. METHODS AND RESULTS: 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI), and clinical traits was analysed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene. The prevalence of HT, DM, and obesity (Ob) was 37, 10, and 21%, respectively. HT, DM, and Ob were associated with older age (P<0.001), less family history of HCM (HT and DM P<0.001), higher New York Heart Association (NYHA) class (P<0.001), atrial fibrillation (HT and DM P<0.001; Ob p = 0.03) and LV (left ventricular) diastolic dysfunction (HT and Ob P<0.001; DM P = 0.003). Stroke was more frequent in HT (P<0.001) and mutation-positive patients with DM (P = 0.02). HT and Ob were associated with higher provocable LV outflow tract gradients (HT P<0.001, Ob P = 0.036). LV hypertrophy was more severe in Ob (P = 0.018). HT and Ob were independently associated with NYHA class (OR 1.419, P = 0.017 and OR 1.584, P = 0.004, respectively). Other associations, including a higher proportion of females in HT and of systolic dysfunction in HT and Ob, were observed only in mutation-positive patients. CONCLUSION: Common CVRF are associated with a more severe HCM phenotype, suggesting a proactive management of CVRF should be promoted. An interaction between genotype and CVRF was observed for some traits. CI - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. FAU - Lopes, Luis R AU - Lopes LR AUID- ORCID: 0000-0002-6408-4667 AD - Servico de Cardiologia, Hospital Garcia de Orta, Av. Torrado da Silva, Almada 2805-267, Portugal. AD - Institute of Cardiovascular Science, University College London, Gower St, London WC1E 6BT, UK. AD - St. Bartholomew's Hospital, Barts Heart Centre, Barts Health NHS Trust, Whitechapel Rd, London E1 1BB, UK. FAU - Losi, Maria-Angela AU - Losi MA AD - Department of Advanced Biomedical Sciences, University Federico II, Corso Umberto I, 40, Naples 80138, Italy. FAU - Sheikh, Nabeel AU - Sheikh N AD - Department of Cardiology and Division of Cardiovascular Sciences, Guy's and St. Thomas' Hospitals and King's College London, Strand, London WC2R 2LS, UK. FAU - Laroche, Cecile AU - Laroche C AD - EORP, European Society of Cardiology, Sophia-Antipolis, France. FAU - Charron, Philippe AU - Charron P AUID- ORCID: 0000-0002-1782-1118 AD - APHP, Centre de Reference des Maladies Cardiaques Hereditaires, Assistance Publique-Hopitaux de Paris, ICAN, Hopital Pitie-Salpetriere, 47-83 Bd de l'Hopital, Paris 75013, France. AD - Sorbonne Universite, Inserm UMR1166, 15-21 Rue de l'Ecole de Medecine, Paris 75006, France. FAU - Gimeno, Juan AU - Gimeno J AD - Hospital Clinico Universitario Virgen de la Arrixaca, Ctra. Madrid-Cartagena, Murcia 30120 El, Spain. FAU - Kaski, Juan P AU - Kaski JP AD - Institute of Cardiovascular Science, University College London, Gower St, London WC1E 6BT, UK. AD - Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London WC1N 3JH, UK. FAU - Maggioni, Aldo P AU - Maggioni AP AUID- ORCID: 0000-0003-2764-6779 AD - EORP, European Society of Cardiology, Sophia-Antipolis, France. AD - Maria Cecilia Hospital, GVM Care&Research, Via Corriera, 1, Cotignola 48033 RA, Italy. FAU - Tavazzi, Luigi AU - Tavazzi L AD - Maria Cecilia Hospital, GVM Care&Research, Via Corriera, 1, Cotignola 48033 RA, Italy. FAU - Arbustini, Eloisa AU - Arbustini E AUID- ORCID: 0000-0003-2948-7994 AD - Centre for Inherited Cardiovascular Diseases, Fondazione IRCCS Policlinico San Matteo, Viale Camillo Golgi, Pavia 27100, Italy. FAU - Brito, Dulce AU - Brito D AD - Servico de Cardiologia, Centro Hospitalar Universitario Lisboa Norte, Lisbon 1169-050, Portugal. AD - CCUL, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz MB, Lisbon 1649-028, Portugal. FAU - Celutkiene, Jelena AU - Celutkiene J AD - Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Universiteto g. 3, Vilnius 01513, Lithuania. AD - State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania. FAU - Hagege, Albert AU - Hagege A AUID- ORCID: 0000-0003-4685-6077 AD - Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges Pompidou, Departement de Cardiologie, Paris, France & Universite Paris Descartes, Sorbonne Paris Cite, Paris 75006, France. FAU - Linhart, Ales AU - Linhart A AUID- ORCID: 0000-0002-3372-7850 AD - 2nd Department of Internal Cardiovascular Medicine, General University Hospital and First Medical Faculty, Charles University, Opletalova 38, Prague 110 00, Czech Republic. FAU - Mogensen, Jens AU - Mogensen J AD - Department of Cardiology, Odense University Hospital, J. B. Winslows Vej 4, Odense 5000, Denmark. FAU - Garcia-Pinilla, Jose Manuel AU - Garcia-Pinilla JM AD - Unidad de Insuficiencia Cardiaca y Cardiopatias Familiares. Servicio de Cardiologia. Hospital Universitario Virgen de la Victoria. IBIMA. Malaga and Ciber-Cardiovascular. Instituto de Salud Carlos III. Madrid, Spain. FAU - Ripoll-Vera, Tomas AU - Ripoll-Vera T AD - Inherited Cardiovascular Disease Unit Son Llatzer University Hospital & IdISBa, Palma de Mallorca, Spain. FAU - Seggewiss, Hubert AU - Seggewiss H AD - Universitatsklinikum Wurzburg, Deutsches Zentrum fur Herzinsuffizienz (DZHI), Comprehensive Heart Failure Center (CHFC), Am Schwarzenberg 15, Haus 15A, 97078 Wurzburg, Germany. FAU - Villacorta, Eduardo AU - Villacorta E AD - Member of National Centers of expertise for familial cardiopathies (CSUR), Cardiology Department, University Hospital of Salamanca. Institute of Biomedical Research of Salamanca (IBSAL), CIBERCV, Salamanca, Spain. FAU - Caforio, Alida AU - Caforio A AUID- ORCID: 0000-0002-4901-5655 AD - Cardiology, Department of Cardiological, Thoracic and Vascular Sciences and Public Health, University of Padova, Via VIII Febbraio, 2, Padova 35122, Italy. FAU - Elliott, Perry M AU - Elliott PM AD - Institute of Cardiovascular Science, University College London, Gower St, London WC1E 6BT, UK. AD - St. Bartholomew's Hospital, Barts Heart Centre, Barts Health NHS Trust, Whitechapel Rd, London E1 1BB, UK. CN - Cardiomyopathy Registry Investigators Group LA - eng GR - MR/T024062/1/Medical Research Council/United Kingdom GR - MR/T005181/1/Medical Research Council/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Eur Heart J Qual Care Clin Outcomes JT - European heart journal. Quality of care & clinical outcomes JID - 101677796 SB - IM MH - Female MH - Humans MH - *Cardiovascular Diseases/epidemiology/genetics/complications MH - Risk Factors MH - *Cardiomyopathy, Hypertrophic/complications/epidemiology/genetics MH - *Cardiomyopathies/complications MH - *Ventricular Dysfunction, Left/complications MH - *Hypertension/complications MH - Obesity/complications/epidemiology MH - Heart Disease Risk Factors PMC - PMC9745665 OTO - NOTNLM OT - Cardiovascular risk factors OT - Diabetes OT - Genotype OT - Hypertension OT - Hypertrophic cardiomyopathy OT - Obesity FIR - Gale, Christopher Peter IR - Gale CP FIR - Beleslin, Branko IR - Beleslin B FIR - Budaj, Andrzej IR - Budaj A FIR - Chioncel, Ovidiu IR - Chioncel O FIR - Dagres, Nikolaos IR - Dagres N FIR - Danchin, Nicolas IR - Danchin N FIR - Erlinge, David IR - Erlinge D FIR - Emberson, Jonathan IR - Emberson J FIR - Glikson, Michael IR - Glikson M FIR - Gray, Alastair IR - Gray A FIR - Kayikcioglu, Meral IR - Kayikcioglu M FIR - Maggioni, Aldo IR - Maggioni A FIR - Nagy, Klaudia Vivien IR - Nagy KV FIR - Nedoshivin, Aleksandr IR - Nedoshivin A FIR - Petronio, Anna-Sonia IR - Petronio AS FIR - Hesselink, Jolien Roo IR - Hesselink JR FIR - Wallentin, Lars IR - Wallentin L FIR - Zeymer, Uwe IR - Zeymer U FIR - Caforio, Alida IR - Caforio A FIR - Blanes, Juan Ramon Gimeno IR - Blanes JRG FIR - Charron, Philippe IR - Charron P FIR - Elliott, Perry IR - Elliott P FIR - Kaski, Juan Pablo IR - Kaski JP FIR - Maggioni, Aldo P IR - Maggioni AP FIR - Tavazzi, Luigi IR - Tavazzi L FIR - Tendera, Michal IR - Tendera M FIR - Komissarova, S IR - Komissarova S FIR - Chakova, N IR - Chakova N FIR - Niyazova, S IR - Niyazova S FIR - Linhart, A IR - Linhart A FIR - Kuchynka, P IR - Kuchynka P FIR - Palecek, T IR - Palecek T FIR - Podzimkova, J IR - Podzimkova J FIR - Fikrle, M IR - Fikrle M FIR - Nemecek, E IR - Nemecek E FIR - Bundgaard, H IR - Bundgaard H FIR - Tfelt-Hansen, J IR - Tfelt-Hansen J FIR - Theilade, J IR - Theilade J FIR - Thune, J J IR - Thune JJ FIR - Axelsson, A IR - Axelsson A FIR - Mogensen, J IR - Mogensen J FIR - Henriksen, F IR - Henriksen F FIR - Hey, T IR - Hey T FIR - Nielsen, S K IR - Nielsen SK FIR - Videbaek, L IR - Videbaek L FIR - Andreasen, S IR - Andreasen S FIR - Arnsted, H IR - Arnsted H FIR - Saad, A IR - Saad A FIR - Ali, M IR - Ali M FIR - Lommi, J IR - Lommi J FIR - Helio, T IR - Helio T FIR - Nieminen, M S IR - Nieminen MS FIR - Dubourg, O IR - Dubourg O FIR - Mansencal, N IR - Mansencal N FIR - Arslan, M IR - Arslan M FIR - Tsieu, V Siam IR - Tsieu VS FIR - Damy, T IR - Damy T FIR - Guellich, A IR - Guellich A FIR - Guendouz, S IR - Guendouz S FIR - Tissot, C M IR - Tissot CM FIR - Lamine, A IR - Lamine A FIR - Rappeneau, S IR - Rappeneau S FIR - Hagege, A IR - Hagege A FIR - Desnos, M IR - Desnos M FIR - Bachet, A IR - Bachet A FIR - Hamzaoui, M IR - Hamzaoui M FIR - Charron, P IR - Charron P FIR - Isnard, R IR - Isnard R FIR - Legrand, L IR - Legrand L FIR - Maupain, C IR - Maupain C FIR - Gandjbakhch, E IR - Gandjbakhch E FIR - Kerneis, M IR - Kerneis M FIR - Pruny, J-F IR - Pruny JF FIR - Bauer, A IR - Bauer A FIR - Pfeiffer, B IR - Pfeiffer B FIR - Felix, S B IR - Felix SB FIR - Dorr, M IR - Dorr M FIR - Kaczmarek, S IR - Kaczmarek S FIR - Lehnert, K IR - Lehnert K FIR - Pedersen, A-L IR - Pedersen AL FIR - Beug, D IR - Beug D FIR - Bruder, M IR - Bruder M FIR - Bohm, M IR - Bohm M FIR - Kindermann, I IR - Kindermann I FIR - Linicus, Y IR - Linicus Y FIR - Werner, C IR - Werner C FIR - Neurath, B IR - Neurath B FIR - Schild-Ungerbuehler, M IR - Schild-Ungerbuehler M FIR - Seggewiss, H IR - Seggewiss H FIR - Pfeiffer, B IR - Pfeiffer B FIR - Neugebauer, A IR - Neugebauer A FIR - McKeown, P IR - McKeown P FIR - Muir, A IR - Muir A FIR - McOsker, J IR - McOsker J FIR - Jardine, T IR - Jardine T FIR - Divine, G IR - Divine G FIR - Elliott, P IR - Elliott P FIR - Lorenzini, M IR - Lorenzini M FIR - Watkinson, O IR - Watkinson O FIR - Wicks, E IR - Wicks E FIR - Iqbal, H IR - Iqbal H FIR - Mohiddin, S IR - Mohiddin S FIR - O'Mahony, C IR - O'Mahony C FIR - Sekri, N IR - Sekri N FIR - Carr-White, G IR - Carr-White G FIR - Bueser, T IR - Bueser T FIR - Rajani, R IR - Rajani R FIR - Clack, L IR - Clack L FIR - Damm, J IR - Damm J FIR - Jones, S IR - Jones S FIR - Sanchez-Vidal, R IR - Sanchez-Vidal R FIR - Smith, M IR - Smith M FIR - Walters, T IR - Walters T FIR - Wilson, K IR - Wilson K FIR - Rosmini, S IR - Rosmini S FIR - Anastasakis, A IR - Anastasakis A FIR - Ritsatos, K IR - Ritsatos K FIR - Vlagkouli, V IR - Vlagkouli V FIR - Forster, T IR - Forster T FIR - Sepp, R IR - Sepp R FIR - Borbas, J IR - Borbas J FIR - Nagy, V IR - Nagy V FIR - Tringer, A IR - Tringer A FIR - Kakonyi, K IR - Kakonyi K FIR - Szabo, L A IR - Szabo LA FIR - Maleki, M IR - Maleki M FIR - Bezanjani, F Noohi IR - Bezanjani FN FIR - Amin, A IR - Amin A FIR - Naderi, N IR - Naderi N FIR - Parsaee, M IR - Parsaee M FIR - Taghavi, S IR - Taghavi S FIR - Ghadrdoost, B IR - Ghadrdoost B FIR - Jafari, S IR - Jafari S FIR - Khoshavi, M IR - Khoshavi M FIR - Rapezzi, C IR - Rapezzi C FIR - Biagini, E IR - Biagini E FIR - Corsini, A IR - Corsini A FIR - Gagliardi, C IR - Gagliardi C FIR - Graziosi, M IR - Graziosi M FIR - Longhi, S IR - Longhi S FIR - Milandri, A IR - Milandri A FIR - Ragni, L IR - Ragni L FIR - Palmieri, S IR - Palmieri S FIR - Olivotto, I IR - Olivotto I FIR - Arretini, A IR - Arretini A FIR - Castelli, G IR - Castelli G FIR - Cecchi, F IR - Cecchi F FIR - Fornaro, A IR - Fornaro A FIR - Tomberli, B IR - Tomberli B FIR - Spirito, P IR - Spirito P FIR - Devoto, E IR - Devoto E FIR - Bella, P Della IR - Bella PD FIR - Maccabelli, G IR - Maccabelli G FIR - Sala, S IR - Sala S FIR - Guarracini, F IR - Guarracini F FIR - Peretto, G IR - Peretto G FIR - Russo, M G IR - Russo MG FIR - Calabro, R IR - Calabro R FIR - Pacileo, G IR - Pacileo G FIR - Limongelli, G IR - Limongelli G FIR - Masarone, D IR - Masarone D FIR - Pazzanese, V IR - Pazzanese V FIR - Rea, A IR - Rea A FIR - Rubino, M IR - Rubino M FIR - Tramonte, S IR - Tramonte S FIR - Valente, F IR - Valente F FIR - Caiazza, M IR - Caiazza M FIR - Cirillo, A IR - Cirillo A FIR - Del Giorno, G IR - Del Giorno G FIR - Esposito, A IR - Esposito A FIR - Gravino, R IR - Gravino R FIR - Marrazzo, T IR - Marrazzo T FIR - Trimarco, B IR - Trimarco B FIR - Losi, M-A IR - Losi MA FIR - Di Nardo, C IR - Di Nardo C FIR - Giamundo, A IR - Giamundo A FIR - Musella, F IR - Musella F FIR - Pacelli, F IR - Pacelli F FIR - Scatteia, A IR - Scatteia A FIR - Canciello, G IR - Canciello G FIR - Caforio, A IR - Caforio A FIR - Iliceto, S IR - Iliceto S FIR - Calore, C IR - Calore C FIR - Leoni, L IR - Leoni L FIR - Marra, M Perazzolo IR - Marra MP FIR - Rigato, I IR - Rigato I FIR - Tarantini, G IR - Tarantini G FIR - Schiavo, A IR - Schiavo A FIR - Testolina, M IR - Testolina M FIR - Arbustini, E IR - Arbustini E FIR - Di Toro, A IR - Di Toro A FIR - Giuliani, L P IR - Giuliani LP FIR - Serio, A IR - Serio A FIR - Fedele, F IR - Fedele F FIR - Frustaci, A IR - Frustaci A FIR - Alfarano, M IR - Alfarano M FIR - Chimenti, C IR - Chimenti C FIR - Drago, F IR - Drago F FIR - Baban, A IR - Baban A FIR - Calo, L IR - Calo L FIR - Lanzillo, C IR - Lanzillo C FIR - Martino, A IR - Martino A FIR - Uguccioni, M IR - Uguccioni M FIR - Zachara, E IR - Zachara E FIR - Halasz, G IR - Halasz G FIR - Re, F IR - Re F FIR - Sinagra, G IR - Sinagra G FIR - Carriere, C IR - Carriere C FIR - Merlo, M IR - Merlo M FIR - Ramani, F IR - Ramani F FIR - Kavoliuniene, A IR - Kavoliuniene A FIR - Krivickiene, A IR - Krivickiene A FIR - Tamuleviciute-Prasciene, E IR - Tamuleviciute-Prasciene E FIR - Viezelis, M IR - Viezelis M FIR - Celutkiene, J IR - Celutkiene J FIR - Balkeviciene, L IR - Balkeviciene L FIR - Laukyte, M IR - Laukyte M FIR - Paleviciute, E IR - Paleviciute E FIR - Pinto, Y IR - Pinto Y FIR - Wilde, A IR - Wilde A FIR - Asselbergs, F W IR - Asselbergs FW FIR - Sammani, A IR - Sammani A FIR - Van Der Heijden, J IR - Van Der Heijden J FIR - Van Laake, L IR - Van Laake L FIR - De Jonge, N IR - De Jonge N FIR - Hassink, R IR - Hassink R FIR - Kirkels, J H IR - Kirkels JH FIR - Ajuluchukwu, J IR - Ajuluchukwu J FIR - Olusegun-Joseph, A IR - Olusegun-Joseph A FIR - Ekure, E IR - Ekure E FIR - Mizia-Stec, K IR - Mizia-Stec K FIR - Tendera, M IR - Tendera M FIR - Czekaj, A IR - Czekaj A FIR - Sikora-Puz, A IR - Sikora-Puz A FIR - Skoczynska, A IR - Skoczynska A FIR - Wybraniec, M IR - Wybraniec M FIR - Rubis, P IR - Rubis P FIR - Dziewiecka, E IR - Dziewiecka E FIR - Wisniowska-Smialek, S IR - Wisniowska-Smialek S FIR - Bilinska, Z IR - Bilinska Z FIR - Chmielewski, P IR - Chmielewski P FIR - Foss-Nieradko, B IR - Foss-Nieradko B FIR - Michalak, E IR - Michalak E FIR - Stepien-Wojno, M IR - Stepien-Wojno M FIR - Mazek, B IR - Mazek B FIR - Lopes, L Rocha IR - Lopes LR FIR - Almeida, A R IR - Almeida AR FIR - Cruz, I IR - Cruz I FIR - Gomes, A C IR - Gomes AC FIR - Pereira, A R IR - Pereira AR FIR - Brito, D IR - Brito D FIR - Madeira, H IR - Madeira H FIR - Francisco, A R IR - Francisco AR FIR - Menezes, M IR - Menezes M FIR - Moldovan, O IR - Moldovan O FIR - Guimaraes, T Oliveira IR - Guimaraes TO FIR - Silva, D IR - Silva D FIR - Ginghina, C IR - Ginghina C FIR - Jurcut, R IR - Jurcut R FIR - Mursa, A IR - Mursa A FIR - Popescu, B A IR - Popescu BA FIR - Apetrei, E IR - Apetrei E FIR - Militaru, S IR - Militaru S FIR - Coman, I Mircea IR - Coman IM FIR - Frigy, A IR - Frigy A FIR - Fogarasi, Z IR - Fogarasi Z FIR - Kocsis, I IR - Kocsis I FIR - Szabo, I A IR - Szabo IA FIR - Fehervari, L IR - Fehervari L FIR - Nikitin, I IR - Nikitin I FIR - Resnik, E IR - Resnik E FIR - Komissarova, M IR - Komissarova M FIR - Lazarev, V IR - Lazarev V FIR - Shebzukhova, M IR - Shebzukhova M FIR - Ustyuzhanin, D IR - Ustyuzhanin D FIR - Blagova, O IR - Blagova O FIR - Alieva, I IR - Alieva I FIR - Kulikova, V IR - Kulikova V FIR - Lutokhina, Y IR - Lutokhina Y FIR - Pavlenko, E IR - Pavlenko E FIR - Varionchik, N IR - Varionchik N FIR - Ristic, A D IR - Ristic AD FIR - Seferovic, P M IR - Seferovic PM FIR - Veljic, I IR - Veljic I FIR - Zivkovic, I IR - Zivkovic I FIR - Milinkovic, I IR - Milinkovic I FIR - Pavlovic, A IR - Pavlovic A FIR - Radovanovic, G IR - Radovanovic G FIR - Simeunovic, D IR - Simeunovic D FIR - Zdravkovic, M IR - Zdravkovic M FIR - Aleksic, M IR - Aleksic M FIR - Djokic, J IR - Djokic J FIR - Hinic, S IR - Hinic S FIR - Klasnja, S IR - Klasnja S FIR - Mircetic, K IR - Mircetic K FIR - Monserrat, L IR - Monserrat L FIR - Fernandez, X IR - Fernandez X FIR - Garcia-Giustiniani, D IR - Garcia-Giustiniani D FIR - Larranaga, J M IR - Larranaga JM FIR - Ortiz-Genga, M IR - Ortiz-Genga M FIR - Barriales-Villa, R IR - Barriales-Villa R FIR - Martinez-Veira, C IR - Martinez-Veira C FIR - Veira, E IR - Veira E FIR - Cequier, A IR - Cequier A FIR - Salazar-Mendiguchia, J IR - Salazar-Mendiguchia J FIR - Manito, N IR - Manito N FIR - Gonzalez, J IR - Gonzalez J FIR - Fernandez-Aviles, F IR - Fernandez-Aviles F FIR - Medrano, C IR - Medrano C FIR - Yotti, R IR - Yotti R FIR - Cuenca, S IR - Cuenca S FIR - Espinosa, M A IR - Espinosa MA FIR - Mendez, I IR - Mendez I FIR - Zatarain, E IR - Zatarain E FIR - Alvarez, R IR - Alvarez R FIR - Pavia, P Garcia IR - Pavia PG FIR - Briceno, A IR - Briceno A FIR - Cobo-Marcos, M IR - Cobo-Marcos M FIR - Dominguez, F IR - Dominguez F FIR - Galvan, E De Teresa IR - Galvan ET FIR - Pinilla, J M Garcia IR - Pinilla JMG FIR - Abdeselam-Mohamed, N IR - Abdeselam-Mohamed N FIR - Lopez-Garrido, M A IR - Lopez-Garrido MA FIR - Hidalgo, L Morcillo IR - Hidalgo LM FIR - Ortega-Jimenez, M V IR - Ortega-Jimenez MV FIR - Mezcua, A Robles IR - Mezcua AR FIR - Guijarro-Contreras, A IR - Guijarro-Contreras A FIR - Gomez-Garcia, D IR - Gomez-Garcia D FIR - Robles-Mezcua, M IR - Robles-Mezcua M FIR - Blanes, J R Gimeno IR - Blanes JRG FIR - Castro, F J IR - Castro FJ FIR - Esparza, C Munoz IR - Esparza CM FIR - Molina, M Sabater IR - Molina MS FIR - Garcia, M Sorli IR - Garcia MS FIR - Cuenca, D Lopez IR - Cuenca DL FIR - de Mallorca, Palma IR - de Mallorca P FIR - Ripoll-Vera, T IR - Ripoll-Vera T FIR - Alvarez, J IR - Alvarez J FIR - Nunez, J IR - Nunez J FIR - Gomez, Y IR - Gomez Y FIR - Fernandez, P L Sanchez IR - Fernandez PLS FIR - Villacorta, E IR - Villacorta E FIR - Avila, C IR - Avila C FIR - Bravo, L IR - Bravo L FIR - Diaz-Pelaez, E IR - Diaz-Pelaez E FIR - Gallego-Delgado, M IR - Gallego-Delgado M FIR - Garcia-Cuenllas, L IR - Garcia-Cuenllas L FIR - Plata, B IR - Plata B FIR - Lopez-Haldon, J E IR - Lopez-Haldon JE FIR - Pena Pena, M L IR - Pena Pena ML FIR - Perez, E M Cantero IR - Perez EMC FIR - Zorio, E IR - Zorio E FIR - Arnau, M A IR - Arnau MA FIR - Sanz, J IR - Sanz J FIR - Marques-Sule, E IR - Marques-Sule E EDAT- 2022/02/10 06:00 MHDA- 2022/12/15 06:00 PMCR- 2022/02/09 CRDT- 2022/02/09 12:17 PHST- 2022/01/04 00:00 [received] PHST- 2022/02/02 00:00 [revised] PHST- 2022/02/04 00:00 [accepted] PHST- 2022/02/10 06:00 [pubmed] PHST- 2022/12/15 06:00 [medline] PHST- 2022/02/09 12:17 [entrez] PHST- 2022/02/09 00:00 [pmc-release] AID - 6524906 [pii] AID - qcac006 [pii] AID - 10.1093/ehjqcco/qcac006 [doi] PST - ppublish SO - Eur Heart J Qual Care Clin Outcomes. 2022 Dec 13;9(1):42-53. doi: 10.1093/ehjqcco/qcac006.