PMID- 35139766
OWN - NLM
STAT- MEDLINE
DCOM- 20220627
LR  - 20220629
IS  - 1532-2335 (Electronic)
IS  - 1525-7770 (Linking)
VI  - 41
IP  - 4
DP  - 2022
TI  - Associations between ERAP1 polymorphisms and ankylosing spondylitis 
      susceptibility in HLA-B27 positive population: a Meta-analysis and bioinformatics 
      analysis.
PG  - 407-418
LID - 10.1080/15257770.2022.2036344 [doi]
AB  - Human leukocyte antigen (HLA)-B27 confers a key role in ankylosing spondylitis 
      (AS) susceptibility. Endoplasmic reticulum aminopeptidase 1 (ERAP1) polymorphisms 
      are associated with AS susceptibility in common population. In this study we 
      intended to evaluate the possible association between ERAP1 polymorphisms and AS 
      susceptibility in HLA-27 positive population. Data were collected from Pubmed, 
      Embase, and Cochrane databases. The pooled odds ratios and 95% confidence 
      intervals of the minor allele of each locus were calculated to appraise the 
      associations under ERAP1 polymorphisms and AS in HLA-B27 positive population. 
      Bioinformatics analysis was performed to explore the underlying mechanism. Four 
      studies were included in this meta-analysis. There was a significant association 
      between the minor allele of rs2287987 and reducing the risk of developing AS in 
      HLA-B27 positive population. But there was no significant association between the 
      minor allele of rs30187, rs27044, rs10050860 and rs17482078 and AS 
      susceptibility. According to HaploReg, 5 motifs changed for rs2287987 were found. 
      The eQTL analysis demonstrated that rs2287987 may influence ERAP1 expression. 
      Rs2287987 in ERAP1 may have small influence on AS susceptibility in HLA-B27 
      positive population. Bioinformatics analysis indicated that the altered motifs 
      and the change of EARP1 expression may influence the AS susceptibility.
FAU - Bai, Yanyan
AU  - Bai Y
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital 
      Affiliated to Shandong First Medical University, Jinan, Shandong, China.
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, Cheeloo 
      College of Medicine, Shandong University, Jinan, Shandong, China.
FAU - Zhao, Na
AU  - Zhao N
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital 
      Affiliated to Shandong First Medical University, Jinan, Shandong, China.
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, Cheeloo 
      College of Medicine, Shandong University, Jinan, Shandong, China.
FAU - Sun, Hongsheng
AU  - Sun H
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital 
      Affiliated to Shandong First Medical University, Jinan, Shandong, China.
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, Cheeloo 
      College of Medicine, Shandong University, Jinan, Shandong, China.
FAU - Yin, Liguo
AU  - Yin L
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital 
      Affiliated to Shandong First Medical University, Jinan, Shandong, China.
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, Cheeloo 
      College of Medicine, Shandong University, Jinan, Shandong, China.
FAU - Chen, Jing
AU  - Chen J
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital 
      Affiliated to Shandong First Medical University, Jinan, Shandong, China.
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, Cheeloo 
      College of Medicine, Shandong University, Jinan, Shandong, China.
FAU - Hu, Naiwen
AU  - Hu N
AUID- ORCID: 0000-0001-7613-7271
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital 
      Affiliated to Shandong First Medical University, Jinan, Shandong, China.
AD  - Department of Rheumatology and Immunology, Shandong Provincial Hospital, Cheeloo 
      College of Medicine, Shandong University, Jinan, Shandong, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20220209
PL  - United States
TA  - Nucleosides Nucleotides Nucleic Acids
JT  - Nucleosides, nucleotides & nucleic acids
JID - 100892832
RN  - 0 (HLA-B27 Antigen)
RN  - 0 (Minor Histocompatibility Antigens)
RN  - EC 3.4.11.- (Aminopeptidases)
RN  - EC 3.4.11.- (ERAP1 protein, human)
SB  - IM
MH  - Aminopeptidases/genetics
MH  - Computational Biology
MH  - Genetic Predisposition to Disease
MH  - HLA-B27 Antigen/genetics
MH  - Humans
MH  - Minor Histocompatibility Antigens/genetics
MH  - Polymorphism, Single Nucleotide
MH  - *Spondylitis, Ankylosing/genetics
OTO - NOTNLM
OT  - Ankylosing spondylitis
OT  - ERAP1
OT  - HLA-B27
OT  - meta-analysis
OT  - polymorphisms
EDAT- 2022/02/11 06:00
MHDA- 2022/06/28 06:00
CRDT- 2022/02/10 05:29
PHST- 2022/02/11 06:00 [pubmed]
PHST- 2022/06/28 06:00 [medline]
PHST- 2022/02/10 05:29 [entrez]
AID - 10.1080/15257770.2022.2036344 [doi]
PST - ppublish
SO  - Nucleosides Nucleotides Nucleic Acids. 2022;41(4):407-418. doi: 
      10.1080/15257770.2022.2036344. Epub 2022 Feb 9.