PMID- 35140487
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220501
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 15
DP  - 2022
TI  - The Association Between Vitamin D and Type 2 Diabetes Mellitus Complicated with 
      Non-Alcoholic Fatty Liver Disease: An Observational Cross-Sectional Study.
PG  - 269-280
LID - 10.2147/DMSO.S348870 [doi]
AB  - OBJECTIVE: To investigate the association between vitamin D deficiency and NAFLD 
      risk in patients with type 2 diabetes mellitus (T2DM). METHODS: Overall, 434 
      patients with T2DM admitted to Hebei General Hospital from January 2019 to 
      December 2019 were selected as the study subjects. According to abdominal 
      ultrasound findings, patients were divided into the NAFLD group and the non-NAFLD 
      group. Participants were divided into two study groups according to the 
      25-hydroxyvitamin D [25(OH)D] level. 25(OH)D deficiency was defined if 25(OH)D 
      vitamin levels were <20 ng/mL. Chi-square test and one-way analysis of variance 
      were used to compare groups. The relationship between 25(OH)D and NAFLD risk was 
      analyzed using correlation and regression analyses. Furthermore, subgroup 
      analyses were performed to verify the robustness of the results. RESULTS: The 
      25(OH)D level in patients with T2DM complicated by NAFLD was significantly lower 
      than in patients with T2DM only. Vitamin D deficiency was highly prevalent among 
      T2DM patients with NAFLD. This study suggested that vitamin D deficiency was an 
      independent factor for developing NAFLD in patients with T2DM. T2DM patients with 
      vitamin D deficiency had 2.045 times higher risk of developing NAFLD than those 
      without vitamin D deficiency. Vitamin D deficiency was associated with high NAFLD 
      preference in T2DM patients with BMI >23kg/m(2), but not those with BMI 
      </=23kg/m(2). The significant correlation between vitamin D deficiency and NAFLD 
      was found in participants with BMI >23kg/m(2), age </=65 years, without 
      hypertension, TG <1.7mmol/l, HDL >/=1 mmol/l in men, >/=1.3 mmol/l in women, HBA1C 
      </=7%, or females. CONCLUSION: This study suggests that T2DM people with BMI 
      >23kg/m(2) were more susceptible to NAFLD by vitamin D deficiency and that it is 
      necessary to maintain optimal serum vitamin D levels in this population.
CI  - (c) 2022 Xing et al.
FAU - Xing, Yuling
AU  - Xing Y
AD  - Department of Endocrinology, Hebei General Hospital, Shijiazhuang, 050017, 
      People's Republic of China.
AD  - Graduate School of Hebei Medical University, Shijiazhuang, 050017, People's 
      Republic of China.
FAU - Cheng, Tiantian
AU  - Cheng T
AD  - Department of Endocrinology, Hebei General Hospital, Shijiazhuang, 050017, 
      People's Republic of China.
AD  - Department of Internal Medicine, School of Clinical Medicine, North China 
      University of Science and Technology, Tangshan, 063210, Hebei, People's Republic 
      of China.
FAU - Zhou, Fei
AU  - Zhou F
AD  - Department of Endocrinology, Hebei General Hospital, Shijiazhuang, 050017, 
      People's Republic of China.
AD  - Graduate School of Hebei Medical University, Shijiazhuang, 050017, People's 
      Republic of China.
FAU - Ma, Huijuan
AU  - Ma H
AUID- ORCID: 0000-0002-4176-5013
AD  - Department of Endocrinology, Hebei General Hospital, Shijiazhuang, 050017, 
      People's Republic of China.
AD  - Hebei Key Laboratory of Metabolic Diseases, Hebei General Hospital Shijiazhuang, 
      Hebei, 050051, People's Republic of China.
AD  - Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, 
      050017, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20220202
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC8819170
OTO - NOTNLM
OT  - non-alcoholic fatty liver disease
OT  - type 2 diabetes mellitus
OT  - vitamin D
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2022/02/11 06:00
MHDA- 2022/02/11 06:01
PMCR- 2022/02/02
CRDT- 2022/02/10 05:33
PHST- 2021/11/11 00:00 [received]
PHST- 2022/01/14 00:00 [accepted]
PHST- 2022/02/10 05:33 [entrez]
PHST- 2022/02/11 06:00 [pubmed]
PHST- 2022/02/11 06:01 [medline]
PHST- 2022/02/02 00:00 [pmc-release]
AID - 348870 [pii]
AID - 10.2147/DMSO.S348870 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2022 Feb 2;15:269-280. doi: 10.2147/DMSO.S348870. 
      eCollection 2022.