PMID- 35140684
OWN - NLM
STAT- MEDLINE
DCOM- 20220302
LR  - 20220302
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 12
DP  - 2021
TI  - Identification of Key LncRNAs and Pathways in Prediabetes and Type 2 Diabetes 
      Mellitus for Hypertriglyceridemia Patients Based on Weighted Gene Co-Expression 
      Network Analysis.
PG  - 800123
LID - 10.3389/fendo.2021.800123 [doi]
LID - 800123
AB  - AIMS: Prevalence of prediabetes and type 2 diabetes mellitus(T2DM) are increasing 
      worldwide. Key lncRNAs were detected to provide a reference for searching 
      potential biomarkers of prediabetes and T2DM in hypertriglyceridemia patients. 
      METHODS: The study included 18 hypertriglyceridemia patients: 6 newly diagnosed 
      type 2 diabetes patients, 6 samples with prediabetes and 6 samples with normal 
      blood glucose. Weighted gene co-expression network analysis (WGCNA) was conducted 
      to construct co-expression network and obtain modules related to blood glucose, 
      thus detecting key lncRNAs. RESULTS: The green, yellow and yellow module was 
      significantly related to blood glucose in T2DM versus normal controls, T2DM 
      versus prediabetes, prediabetes versus normal controls, respectively. 
      ENST00000503273, ENST00000462720, ENST00000480633 and ENST00000485392 were 
      detected as key lncRNAs for the above three groups, respectively. CONCLUSIONS: 
      For hypertriglyceridemia patients with different blood glucose levels, 
      ENST00000503273, ENST00000462720 and ENST00000480633 could be potential 
      biomarkers of T2DM.
CI  - Copyright (c) 2022 Yan, Sun, Gao, Yao, Feng, Yang, Li, Hu, Cui and Li.
FAU - Yan, Shoumeng
AU  - Yan S
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Jilin 
      University, Changchun, China.
FAU - Sun, Mengzi
AU  - Sun M
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Jilin 
      University, Changchun, China.
FAU - Gao, Lichao
AU  - Gao L
AD  - Department of Endocrinology, The First Hospital of Jilin University, Changchun, 
      China.
FAU - Yao, Nan
AU  - Yao N
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Jilin 
      University, Changchun, China.
FAU - Feng, Tianyu
AU  - Feng T
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Jilin 
      University, Changchun, China.
FAU - Yang, Yixue
AU  - Yang Y
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Jilin 
      University, Changchun, China.
FAU - Li, Xiaotong
AU  - Li X
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Jilin 
      University, Changchun, China.
FAU - Hu, Wenyu
AU  - Hu W
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Jilin 
      University, Changchun, China.
FAU - Cui, Weiwei
AU  - Cui W
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Jilin 
      University, Changchun, China.
FAU - Li, Bo
AU  - Li B
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Jilin 
      University, Changchun, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220124
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Blood Glucose)
RN  - 0 (RNA, Long Noncoding)
SB  - IM
MH  - Blood Glucose/genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Gene Regulatory Networks
MH  - Humans
MH  - Hypertriglyceridemia/*genetics
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/*genetics
MH  - RNA, Long Noncoding/*genetics
MH  - Real-Time Polymerase Chain Reaction
MH  - Transcriptome
PMC - PMC8818867
OTO - NOTNLM
OT  - WGCNA
OT  - diabetes
OT  - hypertriglyceridemia
OT  - lncRNAs
OT  - qRT-PCR
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/02/11 06:00
MHDA- 2022/03/03 06:00
PMCR- 2021/01/01
CRDT- 2022/02/10 05:35
PHST- 2021/10/22 00:00 [received]
PHST- 2021/12/13 00:00 [accepted]
PHST- 2022/02/10 05:35 [entrez]
PHST- 2022/02/11 06:00 [pubmed]
PHST- 2022/03/03 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2021.800123 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2022 Jan 24;12:800123. doi: 
      10.3389/fendo.2021.800123. eCollection 2021.