PMID- 35141143
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220501
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 11
DP  - 2021
TI  - Thoracoscopic Lobectomy Versus Sublobar Resection for pStage I Geriatric 
      Non-Small Cell Lung Cancer.
PG  - 777590
LID - 10.3389/fonc.2021.777590 [doi]
LID - 777590
AB  - OBJECTIVES: The choice of resection method for geriatric patients with 
      early-stage non-small cell lung cancer (NSCLC) remains contentious. This study 
      aimed to evaluate survival and perioperative outcomes after thoracoscopic 
      lobectomy resection (LR) or sublobar resection (SR) in patients aged >/=75 years 
      with pathologic stage (pStage) I NSCLC. MATERIALS AND METHODS: We retrospectively 
      examined 258 consecutive patients aged >/=75 years with pStage I NSCLC who 
      underwent thoracoscopic tumor resection at our institute from 2011 to 2018. 
      Propensity score matching (PSM) analysis identified 60 patients in each group for 
      comparison of survival-related parameters, including disease-free survival (DFS), 
      lung cancer-specific overall survival (OS), and non-lung cancer-specific OS, 
      using the Kaplan-Meier analysis. RESULTS: LR and SR were performed in 84 (32.6%) 
      and 174 (67.4%) patients aged >/=75 years, respectively. The LR group had younger 
      patients, better performance status, larger tumor sizes, and deeper tumor 
      location than the SR group. Multivariate studies showed that the resection method 
      was not a prognostic factor for OS. The two PSM-matched groups were not 
      significantly different with respect to lung cancer-specific OS (p = 0.116), 
      non-lung cancer-specific OS (p = 0.408), and DFS (p = 0.597). SR helped achieve 
      better perioperative outcomes than LR, including fewer postoperative 
      complications (10.0% vs. 28.3%, p = 0.011), shorter operative times (p < 0.001), 
      decreased blood loss (p = 0.026), and shorter chest tube duration (p = 0.010) and 
      hospital stays (p = 0.035). CONCLUSIONS: Thoracoscopic SR may provide similar 
      oncological outcomes to LR, but may be a safer and more feasible surgical method 
      for geriatric patients with pStage I NSCLC.
CI  - Copyright (c) 2022 Lin, Chiang, Lu, Hsieh, Lin, Hsu and Chen.
FAU - Lin, Young-Jen
AU  - Lin YJ
AD  - Department of Surgery, National Taiwan University Hospital, and National Taiwan 
      University College of Medicine, Taipei, Taiwan.
FAU - Chiang, Xu-Heng
AU  - Chiang XH
AD  - Department of Surgery, National Taiwan University Hospital, and National Taiwan 
      University College of Medicine, Taipei, Taiwan.
FAU - Lu, Tzu-Pin
AU  - Lu TP
AD  - Institute of Epidemiology and Preventive Medicine, College of Public Health, 
      National Taiwan University, Taipei, Taiwan.
FAU - Hsieh, Min-Shu
AU  - Hsieh MS
AD  - Department of Pathology, National Taiwan University Hospital, and National Taiwan 
      University College of Medicine, Taipei, Taiwan.
FAU - Lin, Mong-Wei
AU  - Lin MW
AD  - Department of Surgery, National Taiwan University Hospital, and National Taiwan 
      University College of Medicine, Taipei, Taiwan.
FAU - Hsu, Hsao-Hsun
AU  - Hsu HH
AD  - Department of Surgery, National Taiwan University Hospital, and National Taiwan 
      University College of Medicine, Taipei, Taiwan.
FAU - Chen, Jin-Shing
AU  - Chen JS
AD  - Department of Surgery, National Taiwan University Hospital, and National Taiwan 
      University College of Medicine, Taipei, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20220124
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC8818756
OTO - NOTNLM
OT  - disease-free survival
OT  - early-stage non-small cell lung cancer
OT  - lobectomy resection
OT  - overall survival
OT  - sublobar resection
OT  - thoracoscopic
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/02/11 06:00
MHDA- 2022/02/11 06:01
PMCR- 2021/01/01
CRDT- 2022/02/10 05:38
PHST- 2021/10/26 00:00 [received]
PHST- 2021/12/28 00:00 [accepted]
PHST- 2022/02/10 05:38 [entrez]
PHST- 2022/02/11 06:00 [pubmed]
PHST- 2022/02/11 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2021.777590 [doi]
PST - epublish
SO  - Front Oncol. 2022 Jan 24;11:777590. doi: 10.3389/fonc.2021.777590. eCollection 
      2021.