PMID- 35141174
OWN - NLM
STAT- MEDLINE
DCOM- 20220406
LR  - 20220406
IS  - 2235-2988 (Electronic)
IS  - 2235-2988 (Linking)
VI  - 12
DP  - 2022
TI  - Epstein-Barr Virus-Associated Smooth Muscle Tumor and Its Correlation With CD4 
      Levels in a Patient With HIV Infection.
PG  - 725342
LID - 10.3389/fcimb.2022.725342 [doi]
LID - 725342
AB  - Epstein-Barr virus-associated smooth muscle tumor (EBV-SMT) is a rare tumor found 
      in immunocompromised patients, and its treatment is not well-established. A role 
      for antiretroviral therapy in human immunodeficiency virus (HIV)-related EBV-SMT 
      has been proposed; however, the relevance of tumor size, CD4 levels, and immune 
      reconstitution inflammatory syndrome (IRIS) has not been previously reported. We 
      present the first case, to our knowledge, of a tumor that shrank in association 
      with elevated CD4 counts. IRIS occurred in this case following antiretroviral 
      therapy. This finding highlights the importance of the immune response in 
      HIV-related EBV-SMT.
CI  - Copyright (c) 2022 Chong, Lu, Ma, Yin and Chang.
FAU - Chong, Yoon Bin
AU  - Chong YB
AD  - Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University 
      Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
FAU - Lu, Po-Liang
AU  - Lu PL
AD  - School of Medicine for Post-Baccalaureate, College of Medicine, Kaohsiung Medical 
      University, Kaohsiung, Taiwan.
AD  - Division of Infectious Disease, Department of Internal Medicine, Kaohsiung 
      Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
AD  - Center for Liquid Biopsy and Cohort Research, Kaohsiung Medical University, 
      Kaohsiung, Taiwan.
FAU - Ma, Yu-Chun
AU  - Ma YC
AD  - Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical 
      University, Kaohsiung, Taiwan.
FAU - Yin, Hsin-Ling
AU  - Yin HL
AD  - Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical 
      University, Kaohsiung, Taiwan.
FAU - Chang, Chih-Hui
AU  - Chang CH
AD  - Division of Neurosurgery, Department of Surgery, Kaohsiung Medical University 
      Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20220124
PL  - Switzerland
TA  - Front Cell Infect Microbiol
JT  - Frontiers in cellular and infection microbiology
JID - 101585359
SB  - IM
MH  - *Epstein-Barr Virus Infections/complications/pathology
MH  - *HIV Infections/complications/drug therapy
MH  - Herpesvirus 4, Human
MH  - Humans
MH  - Immunocompromised Host
MH  - *Smooth Muscle Tumor/complications/pathology
PMC - PMC8818939
OTO - NOTNLM
OT  - CD4
OT  - HAART
OT  - HIV
OT  - IRIS - immune reconstitution inflammatory syndrome
OT  - case report
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/02/11 06:00
MHDA- 2022/04/07 06:00
PMCR- 2022/01/01
CRDT- 2022/02/10 05:38
PHST- 2021/09/01 00:00 [received]
PHST- 2022/01/03 00:00 [accepted]
PHST- 2022/02/10 05:38 [entrez]
PHST- 2022/02/11 06:00 [pubmed]
PHST- 2022/04/07 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fcimb.2022.725342 [doi]
PST - epublish
SO  - Front Cell Infect Microbiol. 2022 Jan 24;12:725342. doi: 
      10.3389/fcimb.2022.725342. eCollection 2022.