PMID- 35141876 OWN - NLM STAT- MEDLINE DCOM- 20220707 LR - 20240210 IS - 1365-2133 (Electronic) IS - 0007-0963 (Print) IS - 0007-0963 (Linking) VI - 187 IP - 1 DP - 2022 Jul TI - Cost-effectiveness of a policy-based intervention to reduce melanoma and other skin cancers associated with indoor tanning. PG - 105-114 LID - 10.1111/bjd.21046 [doi] AB - BACKGROUND: The use of indoor tanning devices causes melanoma and other skin cancers with resulting morbidity, mortality and increased healthcare costs. Policymakers require robust economic evidence to inform decisions about a possible ban of such devices to mitigate these burdens. OBJECTIVES: To assess the health costs and consequences of introducing a policy-based intervention across England to ban commercial indoor tanning with an accompanying public information campaign. METHODS: A cost-effectiveness analysis, adopting a healthcare system perspective, was conducted using a decision model to track a national cohort of 18-year-olds over a lifetime time horizon. A nationwide ban on commercial indoor tanning combined with a public information campaign (the policy-based intervention) was compared with the status quo of availability of commercial indoor tanning. The expected costs (currency, GBP; price year, 2019) and quality-adjusted life-years (QALYs) were calculated. Net monetary benefit (NMB) (net benefit measured in cost compared with an accepted threshold) and net health benefit (NHB) (net gain in QALYs compared with an accepted threshold) of implementation were calculated. A probabilistic sensitivity analysis was used to calculate the probability that the intervention was cost-effective. RESULTS: Compared with the current situation, a ban on commercial indoor tanning combined with a public information campaign would result in 1206 avoided cases of melanoma, 207 fewer melanoma deaths and 3987 averted cases of keratinocyte cancers over the lifetime of all 18-year-olds (n = 618 873) living in England in 2019. An additional 497 QALYs would be realized along with healthcare cost-savings of pound697 858. This intervention would result in an NMB of pound10.6m and an NHB of 530 QALYS. Multiple sensitivity analyses confirmed the robustness of the findings. At a cost-effectiveness threshold of pound20 000, there is a 99% likelihood of this policy-based intervention being cost-effective. CONCLUSIONS: The implementation of a ban on commercial indoor tanning across England with an accompanying public information campaign would be an effective use of healthcare resources. CI - (c) 2022 The Authors. British Journal of Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists. FAU - Eden, Martin AU - Eden M AUID- ORCID: 0000-0002-1542-2527 AD - Manchester Centre for Health Economics, Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, The University of Manchester, Manchester, UK. FAU - Hainsworth, Rob AU - Hainsworth R AUID- ORCID: 0000-0002-3475-800X AD - Manchester Centre for Health Economics, Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, The University of Manchester, Manchester, UK. FAU - Gordon, Louisa G AU - Gordon LG AUID- ORCID: 0000-0002-3159-4249 AD - Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia. AD - School of Nursing, Queensland University of Technology (QUT), Brisbane, Australia. AD - School of Public Health, University of Queensland, Brisbane, Australia. FAU - Epton, Tracy AU - Epton T AUID- ORCID: 0000-0002-1653-191X AD - Manchester Centre for Health Psychology, Division of Psychology & Mental Health, School of Health Sciences, The University of Manchester, Manchester, UK. FAU - Lorigan, Paul AU - Lorigan P AUID- ORCID: 0000-0002-8875-2164 AD - The Christie NHS Foundation Trust, Manchester, UK. AD - Division of Cancer Sciences, School of Medical Sciences, The University of Manchester, Manchester, UK. FAU - Rhodes, Lesley E AU - Rhodes LE AUID- ORCID: 0000-0002-9107-6654 AD - Centre for Dermatology Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology Medicine and Health, The University of Manchester and Salford Royal NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. FAU - Marais, Richard AU - Marais R AUID- ORCID: 0000-0001-7484-4183 AD - Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK. FAU - Green, Adele C AU - Green AC AUID- ORCID: 0000-0002-2753-4841 AD - Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia. AD - Cancer Research UK Manchester Institute, The University of Manchester, Manchester, UK. FAU - Payne, Katherine AU - Payne K AUID- ORCID: 0000-0002-3938-4350 AD - Manchester Centre for Health Economics, Division of Population Health, Health Services Research and Primary Care, School of Health Sciences, The University of Manchester, Manchester, UK. LA - eng GR - ERC Advanced Grant No. 671262/ERC_/European Research Council/International GR - 100282/Z/12/Z/WT_/Wellcome Trust/United Kingdom GR - A27412 & A22902/CRUK_/Cancer Research UK/United Kingdom GR - 22902/CRUK_/Cancer Research UK/United Kingdom PT - Journal Article DEP - 20220518 PL - England TA - Br J Dermatol JT - The British journal of dermatology JID - 0004041 SB - IM CIN - Br J Dermatol. 2022 Jul;187(1):7. PMID: 35508361 CIN - Br J Dermatol. 2022 Dec;187(6):1057. PMID: 35972386 CIN - Br J Dermatol. 2022 Dec;187(6):1057-1058. PMID: 36113867 MH - Cost-Benefit Analysis MH - Humans MH - *Melanoma/epidemiology/etiology/prevention & control MH - Policy MH - *Skin Neoplasms/epidemiology/etiology/prevention & control MH - *Sunbathing MH - Syndrome PMC - PMC9541204 EDAT- 2022/02/11 06:00 MHDA- 2022/07/08 06:00 PMCR- 2022/10/07 CRDT- 2022/02/10 05:42 PHST- 2022/01/27 00:00 [revised] PHST- 2021/11/11 00:00 [received] PHST- 2022/02/06 00:00 [accepted] PHST- 2022/02/11 06:00 [pubmed] PHST- 2022/07/08 06:00 [medline] PHST- 2022/02/10 05:42 [entrez] PHST- 2022/10/07 00:00 [pmc-release] AID - BJD21046 [pii] AID - 10.1111/bjd.21046 [doi] PST - ppublish SO - Br J Dermatol. 2022 Jul;187(1):105-114. doi: 10.1111/bjd.21046. Epub 2022 May 18.