PMID- 35142077
OWN - NLM
STAT- MEDLINE
DCOM- 20220414
LR  - 20220731
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Print)
IS  - 1930-7381 (Linking)
VI  - 30
IP  - 3
DP  - 2022 Mar
TI  - Infant weight growth patterns, childhood BMI, and arterial health at age 10 
      years.
PG  - 770-778
LID - 10.1002/oby.23376 [doi]
AB  - OBJECTIVE: Associations of obesity with cardiovascular disease may originate in 
      childhood. This study examined critical periods for BMI in relation to arterial 
      health at school age. METHODS: Among 4,731 children from a prospective cohort 
      study, associations of infant peak weight velocity, both age and BMI at adiposity 
      peak, and BMI trajectories with carotid artery intima-media thickness and carotid 
      artery distensibility at 10 years were examined. RESULTS: A 1-standard deviation 
      score (SDS) higher peak weight velocity and BMI at adiposity peak were associated 
      with higher intima-media thickness (0.10 SDS; 95% CI: 0.06 to 0.13 and 0.08 SDS; 
      95% CI: 0.05 to 0.12) and lower distensibility (-0.07 SDS; 95% CI: -0.10 to -0.03 
      and -0.07 SDS; 95% CI: -0.11 to -0.03) at 10 years. For distensibility, current 
      BMI explained these associations. Children within the highest BMI tertile at ages 
      2 and 10 years had the lowest distensibility (p < 0.05), but similar intima-media 
      thickness, compared with children constantly within the middle tertile. 
      CONCLUSIONS: Infant weight growth patterns and childhood BMI are associated with 
      subtle differences in carotid intima-media thickness and carotid distensibility 
      at school age. For distensibility, current BMI seems critical. Follow-up is 
      needed to determine whether these associations lead to adult cardiovascular 
      disease.
CI  - (c) 2022 The Authors. Obesity published by Wiley Periodicals LLC on behalf of The 
      Obesity Society (TOS).
FAU - Monasso, Giulietta S
AU  - Monasso GS
AD  - The Generation R Study Group, Erasmus University Medical Center, Rotterdam, the 
      Netherlands.
AD  - Department of Pediatrics, Erasmus University Medical Center, Rotterdam, the 
      Netherlands.
FAU - Silva, Carolina C V
AU  - Silva CCV
AD  - The Generation R Study Group, Erasmus University Medical Center, Rotterdam, the 
      Netherlands.
AD  - Department of Pediatrics, Erasmus University Medical Center, Rotterdam, the 
      Netherlands.
FAU - Santos, Susana
AU  - Santos S
AUID- ORCID: 0000-0003-0613-3181
AD  - The Generation R Study Group, Erasmus University Medical Center, Rotterdam, the 
      Netherlands.
AD  - Department of Pediatrics, Erasmus University Medical Center, Rotterdam, the 
      Netherlands.
FAU - Goncalvez, Romy
AU  - Goncalvez R
AD  - The Generation R Study Group, Erasmus University Medical Center, Rotterdam, the 
      Netherlands.
AD  - Department of Obstetrics and Gynaecology, Erasmus University Medical Center, 
      Rotterdam, the Netherlands.
FAU - Gaillard, Romy
AU  - Gaillard R
AUID- ORCID: 0000-0002-7967-4600
AD  - The Generation R Study Group, Erasmus University Medical Center, Rotterdam, the 
      Netherlands.
AD  - Department of Pediatrics, Erasmus University Medical Center, Rotterdam, the 
      Netherlands.
FAU - Felix, Janine F
AU  - Felix JF
AD  - The Generation R Study Group, Erasmus University Medical Center, Rotterdam, the 
      Netherlands.
AD  - Department of Pediatrics, Erasmus University Medical Center, Rotterdam, the 
      Netherlands.
FAU - Jaddoe, Vincent W V
AU  - Jaddoe VWV
AUID- ORCID: 0000-0003-2939-0041
AD  - The Generation R Study Group, Erasmus University Medical Center, Rotterdam, the 
      Netherlands.
AD  - Department of Pediatrics, Erasmus University Medical Center, Rotterdam, the 
      Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220210
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
SB  - IM
MH  - Adult
MH  - Body Mass Index
MH  - *Cardiovascular Diseases/complications/etiology
MH  - *Carotid Intima-Media Thickness
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Obesity/complications
MH  - Prospective Studies
MH  - Risk Factors
PMC - PMC9302666
COIS- The authors declared no conflict of interest.
EDAT- 2022/02/11 06:00
MHDA- 2022/04/15 06:00
PMCR- 2022/07/21
CRDT- 2022/02/10 05:45
PHST- 2021/11/26 00:00 [revised]
PHST- 2021/10/20 00:00 [received]
PHST- 2021/12/14 00:00 [accepted]
PHST- 2022/02/11 06:00 [pubmed]
PHST- 2022/04/15 06:00 [medline]
PHST- 2022/02/10 05:45 [entrez]
PHST- 2022/07/21 00:00 [pmc-release]
AID - OBY23376 [pii]
AID - 10.1002/oby.23376 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2022 Mar;30(3):770-778. doi: 10.1002/oby.23376. Epub 
      2022 Feb 10.