PMID- 35142186
OWN - NLM
STAT- MEDLINE
DCOM- 20220211
LR  - 20220211
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 68
IP  - 2
DP  - 2022 Feb 1
TI  - Verification and Establishment of Reference Intervals for Prothrombin Time and 
      Activated Partial Thromboplastin Time for Children in a Clinical Laboratory.
LID - 10.7754/Clin.Lab.2021.210539 [doi]
AB  - BACKGROUND: Prothrombin time (PT) and activated partial thromboplastin time 
      (aPTT) are routine coagulation tests. The absence of age-dependent reference 
      interval (RI) may lead to abnormal results in children. In this study, we aimed 
      to verify adult-based RIs in children and establish pediatric RIs for PT and 
      aPTT. METHODS: We analyzed PT and aPTT results. Samples from inpatients and 
      outpatients aged 1 - 18 years, considered healthy subjects, were divided into six 
      groups by age. Verification and establishment of RIs were conducted. RESULTS: 
      Applying adult-based RIs to pediatrics was statistically invalid for individuals 
      aged 10 - 18 years for PT and invalid throughout childhood for aPTT. The new RI 
      of PT for individuals aged 10 - 18 years was 11.1 - 14.1 seconds and that of aPTT 
      for individuals aged 1 - 9 years was 28.2 - 46.0 seconds. CONCLUSIONS: Pediatric 
      RIs were higher than adult-based RIs. Using pediatric RI can save time, labor, 
      and costs to make clinical decision.
FAU - Lee, Min Young
AU  - Lee MY
FAU - Lee, Woo In
AU  - Lee WI
FAU - Kang, So Young
AU  - Kang SY
FAU - Kim, Myeong Hee
AU  - Kim MH
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Coagulation Tests
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Infant
MH  - *Laboratories, Clinical
MH  - Partial Thromboplastin Time
MH  - Prothrombin Time
MH  - Reference Values
EDAT- 2022/02/11 06:00
MHDA- 2022/02/12 06:00
CRDT- 2022/02/10 06:07
PHST- 2022/02/10 06:07 [entrez]
PHST- 2022/02/11 06:00 [pubmed]
PHST- 2022/02/12 06:00 [medline]
AID - 10.7754/Clin.Lab.2021.210539 [doi]
PST - ppublish
SO  - Clin Lab. 2022 Feb 1;68(2). doi: 10.7754/Clin.Lab.2021.210539.