PMID- 35144649 OWN - NLM STAT- MEDLINE DCOM- 20220328 LR - 20220328 IS - 1476-511X (Electronic) IS - 1476-511X (Linking) VI - 21 IP - 1 DP - 2022 Feb 10 TI - Effects of marine-derived and plant-derived omega-3 polyunsaturated fatty acids on erythrocyte fatty acid composition in type 2 diabetic patients. PG - 20 LID - 10.1186/s12944-022-01630-0 [doi] LID - 20 AB - BACKGROUND: Dietary fatty acids intake affects the composition of erythrocyte fatty acids, which is strongly correlated with glycolipid metabolism disorders. This study aimed at investigating the different effects of marine-derived and plant-derived omega-3 polyunsaturated fatty acid (n-3 PUFA) on the fatty acids of erythrocytes and glycolipid metabolism in patients with type 2 diabetes mellitus (T2DM). METHODS: The randomized double-blinded trial that was performed on 180 T2DM patients. The participants were randomly assigned to three groups for the six-month intervention. The participants were randomly assigned to three groups for the six-month intervention. The fish oil (FO) group was administered with FO at a dose of 3 g/day containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the perilla oil (PO) group was administered with PO at a dose of 3 g/day containing alpha-linolenic (ALA), the linseed and fish oil (LFO) group was administered with mixed linseed and fish oil at a dose of 3 g/day containing EPA, DHA and ALA. Demographic information were collected and anthropometric indices, glucose and lipid metabolism indexes, erythrocyte fatty acid composition were measured. Statistical analyses were performed using two-way ANOVA. RESULTS: A total of 150 patients finished the trial, with 52 of them in the FO group, 50 in the PO group and 48 in the LFO group. There were significant effects of time x treatment interaction on fast blood glucose (FBG), insulin, HOMA-IR and C-peptide, TC and triglyceride (TG) levels (P < 0.001). Glucose and C-peptide in PO and LFO groups decreased significantly and serum TG in FO group significantly decreased (P < 0.001) after the intervention. Erythrocyte C22: 5 n-6, ALA, DPA, n-6/n-3 PUFA, AA/EPA levels in the PO group were significantly higher than FO and LFO groups, while EPA, total n-3 PUFA and Omega-3 index were significantly higher in the FO and LFO groups compared to PO group. CONCLUSION: Supplementation with perilla oil decreased FBG while fish oil supplementation decreased the TG level. Marine-based and plant-based n-3 PUFAs exhibit different effects on fatty acid compositions of erythrocytes and regulated glycolipid metabolism. TRIAL REGISTRATION: This trial was recorded under Chinese Clinical Trial Registry Center (NO: ChiCTR-IOR-16008435 ) on May 28 2016. CI - (c) 2022. The Author(s). FAU - Liu, Hechun AU - Liu H AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, 87 Ding Jia Qiao Road, Nanjing, 210009, China. FAU - Wang, Feng AU - Wang F AD - Tianjin Institute of Environmental and Operational Medicine, 1 Da Li Road, Tianjin, 300050, China. FAU - Liu, Xiaosong AU - Liu X AD - Guanlin Hospital, 17 Wenwei Road, Yixing, 214251, China. FAU - Xie, Yulan AU - Xie Y AD - Zhongda Hospital Southeast University, 87 Ding Jia Qiao Road, Nanjing, 210009, China. FAU - Xia, Hui AU - Xia H AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, 87 Ding Jia Qiao Road, Nanjing, 210009, China. FAU - Wang, Shaokang AU - Wang S AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, 87 Ding Jia Qiao Road, Nanjing, 210009, China. FAU - Sun, Guiju AU - Sun G AUID- ORCID: 0000-0001-5969-2185 AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, 87 Ding Jia Qiao Road, Nanjing, 210009, China. gjsun@seu.edu.cn. LA - eng GR - 81872618/National Natural Science Foundation of China/ GR - 81573144/National Natural Science Foundation of China/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20220210 PL - England TA - Lipids Health Dis JT - Lipids in health and disease JID - 101147696 RN - 0 (Fatty Acids) RN - 0 (Fatty Acids, Omega-3) RN - 0 (Fish Oils) RN - 0 (Plant Oils) RN - 0RBV727H71 (alpha-Linolenic Acid) RN - 68132-21-8 (perilla seed oil) SB - IM MH - Diabetes Mellitus, Type 2/*blood MH - Double-Blind Method MH - Dyslipidemias/drug therapy MH - Erythrocytes/chemistry/*drug effects MH - Fatty Acids/*blood MH - Fatty Acids, Omega-3/*therapeutic use MH - Female MH - Fish Oils/*therapeutic use MH - Humans MH - Male MH - Middle Aged MH - Plant Oils/therapeutic use MH - alpha-Linolenic Acid/*therapeutic use PMC - PMC8832668 OTO - NOTNLM OT - Erythrocyte OT - Glucose OT - Polyunsaturated fatty acids OT - Type 2 diabetes COIS- There are no conflicts to declare. EDAT- 2022/02/12 06:00 MHDA- 2022/03/29 06:00 PMCR- 2022/02/10 CRDT- 2022/02/11 05:31 PHST- 2021/10/26 00:00 [received] PHST- 2022/01/28 00:00 [accepted] PHST- 2022/02/11 05:31 [entrez] PHST- 2022/02/12 06:00 [pubmed] PHST- 2022/03/29 06:00 [medline] PHST- 2022/02/10 00:00 [pmc-release] AID - 10.1186/s12944-022-01630-0 [pii] AID - 1630 [pii] AID - 10.1186/s12944-022-01630-0 [doi] PST - epublish SO - Lipids Health Dis. 2022 Feb 10;21(1):20. doi: 10.1186/s12944-022-01630-0.