PMID- 35145730
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220501
IS  - 2055-2173 (Print)
IS  - 2055-2173 (Electronic)
IS  - 2055-2173 (Linking)
VI  - 6
IP  - 4
DP  - 2020 Oct-Dec
TI  - Functional evolution of visual involvement in experimental autoimmune 
      encephalomyelitis.
PG  - 2055217320963474
LID - 10.1177/2055217320963474 [doi]
LID - 2055217320963474
AB  - BACKGROUND: Experimental autoimmune encephalomyelitis (EAE) is a common animal 
      model of multiple sclerosis (MS). C57BL/6 mice immunized with myelin 
      oligodendrocyte glycoprotein exhibit chronic disease course, together with optic 
      neuritis, consisting of demyelination/axonal loss of the optic nerve. OBJECTIVES: 
      To characterize functional and structural visual damages in two different phases 
      of EAE: pre- and post-motor onset. METHODS: Visual alterations were detected with 
      Visual Evoked Potential (VEP), Electroretinogram (ERG) and Optical Coherence 
      Tomography (OCT). Optic nerve histology was performed at 7 (pre-motor onset) or 
      37 (post-motor onset) days post-immunization (dpi). RESULTS: At 7 dpi, optic 
      nerve inflammation was similar in EAE eyes with and without VEP latency delay. 
      Demyelination was detected in EAE eyes with latency delay (p < 0.0001), while 
      axonal loss (p < 0.0001) and ERG b-wave amplitude (p = 0.004) were decreased in 
      EAE eyes without latency delay compared to Healthy controls. At 37 dpi, 
      functional and structural optic nerve damage were comparable between EAE groups, 
      while a decrease of ERG amplitude and NGCC thickness were found in EAE eyes with 
      VEP latency delay detected post-motor onset. CONCLUSIONS: Thanks to non-invasive 
      methods, we studied the visual system in a MS model, which could be useful for 
      developing specific therapeutic strategies to target different disease phases.
CI  - (c) The Author(s) 2020.
FAU - Marenna, Silvia
AU  - Marenna S
AD  - Experimental Neurophysiology Unit, Institute of Experimental Neurology-INSPE, 
      IRCCS San Raffaele Hospital, Milan, Italy.
FAU - Huang, Su-Chun
AU  - Huang SC
AD  - Experimental Neurophysiology Unit, Institute of Experimental Neurology-INSPE, 
      IRCCS San Raffaele Hospital, Milan, Italy.
FAU - Castoldi, Valerio
AU  - Castoldi V
AD  - Experimental Neurophysiology Unit, Institute of Experimental Neurology-INSPE, 
      IRCCS San Raffaele Hospital, Milan, Italy.
FAU - d'Isa, Raffaele
AU  - d'Isa R
AD  - Experimental Neurophysiology Unit, Institute of Experimental Neurology-INSPE, 
      IRCCS San Raffaele Hospital, Milan, Italy.
FAU - Costa, Gloria Dalla
AU  - Costa GD
AD  - Experimental Neurophysiology Unit, Institute of Experimental Neurology-INSPE, 
      IRCCS San Raffaele Hospital, Milan, Italy.
FAU - Comi, Giancarlo
AU  - Comi G
AD  - Experimental Neurophysiology Unit, Institute of Experimental Neurology-INSPE, 
      IRCCS San Raffaele Hospital, Milan, Italy.
FAU - Leocani, Letizia
AU  - Leocani L
AUID- ORCID: 0000-0001-9326-6753
AD  - Experimental Neurophysiology Unit, Institute of Experimental Neurology-INSPE, 
      IRCCS San Raffaele Hospital, Milan, Italy.
LA  - eng
PT  - Journal Article
DEP - 20201028
PL  - United States
TA  - Mult Scler J Exp Transl Clin
JT  - Multiple sclerosis journal - experimental, translational and clinical
JID - 101668877
PMC - PMC8822451
OTO - NOTNLM
OT  - Experimental autoimmune encephalomyelitis
OT  - electroretinogram
OT  - optical coherence tomography
OT  - visual evoked potential
OT  - visual system
EDAT- 2020/10/28 00:00
MHDA- 2020/10/28 00:01
PMCR- 2020/10/28
CRDT- 2022/02/11 05:40
PHST- 2020/05/04 00:00 [received]
PHST- 2020/09/12 00:00 [accepted]
PHST- 2022/02/11 05:40 [entrez]
PHST- 2020/10/28 00:00 [pubmed]
PHST- 2020/10/28 00:01 [medline]
PHST- 2020/10/28 00:00 [pmc-release]
AID - 10.1177_2055217320963474 [pii]
AID - 10.1177/2055217320963474 [doi]
PST - epublish
SO  - Mult Scler J Exp Transl Clin. 2020 Oct 28;6(4):2055217320963474. doi: 
      10.1177/2055217320963474. eCollection 2020 Oct-Dec.