PMID- 35146486
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220216
IS  - 2673-3129 (Electronic)
IS  - 2673-3129 (Linking)
VI  - 3
DP  - 2021
TI  - Drug Delivery Systems for the Oral Administration of Antimicrobial Peptides: 
      Promising Tools to Treat Infectious Diseases.
PG  - 778645
LID - 10.3389/fmedt.2021.778645 [doi]
LID - 778645
AB  - Antimicrobial peptides (AMPs) have a great potential to face the global expansion 
      of antimicrobial resistance (AMR) associated to the development of 
      multidrug-resistant (MDR) pathogens. AMPs are usually composed of 10-50 amino 
      acids with a broad structural diversity and present a range of antimicrobial 
      activities. Unfortunately, even if the oral route is the most convenient one, 
      currently approved therapeutic AMPs are mostly administrated by the intravenous 
      route. Thus, the development of novel drug delivery systems (DDSs) represents a 
      promising opportunity to protect AMPs from chemical and enzymatic degradation 
      through the gastrointestinal tract and to increase intestinal permeability 
      leading to high bioavailability. In this review, the classification and 
      properties as well as mechanisms of the AMPs used in infectiology are first 
      described. Then, the different pharmaceutical forms existing in the market for 
      oral administration are presented. Finally, the formulation technologies, 
      including microparticle- and nanoparticle-based DDSs, used to improve the oral 
      bioavailability of AMPs are reviewed.
CI  - Copyright (c) 2022 Deshayes, Arafath, Apaire-Marchais and Roger.
FAU - Deshayes, Caroline
AU  - Deshayes C
AD  - University of Angers, INRAE, SIFCIR, SFR QUASAV, Angers, France.
FAU - Arafath, Md Nasir
AU  - Arafath MN
AD  - University of Angers, INSERM, CNRS, MINT, SFR ICAT, Angers, France.
FAU - Apaire-Marchais, Veronique
AU  - Apaire-Marchais V
AD  - University of Angers, INRAE, SIFCIR, SFR QUASAV, Angers, France.
FAU - Roger, Emilie
AU  - Roger E
AD  - University of Angers, INSERM, CNRS, MINT, SFR ICAT, Angers, France.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220125
PL  - Switzerland
TA  - Front Med Technol
JT  - Frontiers in medical technology
JID - 101772626
PMC - PMC8821882
OTO - NOTNLM
OT  - antimicrobial peptides (AMPs)
OT  - drug delivery systems (DDS)
OT  - infectiology
OT  - oral route
OT  - pharmaceutical forms
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/02/12 06:00
MHDA- 2022/02/12 06:01
PMCR- 2022/01/25
CRDT- 2022/02/11 05:45
PHST- 2021/09/17 00:00 [received]
PHST- 2021/12/06 00:00 [accepted]
PHST- 2022/02/11 05:45 [entrez]
PHST- 2022/02/12 06:00 [pubmed]
PHST- 2022/02/12 06:01 [medline]
PHST- 2022/01/25 00:00 [pmc-release]
AID - 10.3389/fmedt.2021.778645 [doi]
PST - epublish
SO  - Front Med Technol. 2022 Jan 25;3:778645. doi: 10.3389/fmedt.2021.778645. 
      eCollection 2021.