PMID- 35148229
OWN - NLM
STAT- MEDLINE
DCOM- 20220412
LR  - 20221207
IS  - 1502-7686 (Electronic)
IS  - 0036-5513 (Linking)
VI  - 82
IP  - 2
DP  - 2022 Apr
TI  - Glycated albumin in pregnancy: LC-MS/MS-based reference interval in healthy, 
      nulliparous Scandinavian women and its diagnostic accuracy in gestational 
      diabetes mellitus.
PG  - 123-131
LID - 10.1080/00365513.2022.2033827 [doi]
AB  - Glycated albumin (GA) may be a useful biomarker of glycemia in pregnancy. The aim 
      of this study was to establish the reference interval (RI) for GA, analyzed by 
      liquid chromatography-tandem mass spectrometry (LC-MS/MS), in healthy, 
      nulliparous pregnant women. In addition, we assessed the accuracy of GA and 
      glycated hemoglobin A1c (HbA1c) in the diagnosis of gestational diabetes mellitus 
      (GDM). Finally, we explored the prevalence of GDM in healthy nulliparas, 
      comparing three diagnostic guidelines (WHO-1999, WHO-2013 and the Norwegian 
      guideline). The study was carried out at Stavanger University Hospital, Norway, 
      and included a study population of 147 pregnant nulliparous women. An oral 
      glucose tolerance test (OGTT) was performed and used as the gold standard for GDM 
      diagnosis. Blood samples for analysis of GA and HbA1c were collected at pregnancy 
      week 24-28. A nonparametric approach was chosen for RI calculation, and receiver 
      operating characteristic (ROC) curves were used to evaluate the diagnostic 
      performance of GA and HbA1c. The established RI for GA in 121 pregnant women was 
      7.1-11.6%. The area under the ROC curves (AUCs) were 0.531 (GA) and 0.627 
      (HbA1c). According to the WHO-1999, WHO-2013 and the Norwegian guideline, 
      respectively, 24 (16%), 36 (24%) and 21 (14%) women were diagnosed with GDM. Only 
      nine women (6%) fulfilled the GDM-criteria of all guidelines. In conclusion, we 
      established the first LC-MS/MS-based RI for GA in pregnant women. At pregnancy 
      weeks 24-28, neither GA nor HbA1c discriminated between those with and without 
      GDM. Different women were diagnosed with GDM using the three guidelines.
FAU - Toft, Johanne Holm
AU  - Toft JH
AUID- ORCID: 0000-0003-4583-2743
AD  - Department of Obstetrics and Gynecology, Stavanger University Hospital, 
      Stavanger, Norway.
AD  - Department of Clinical Science, University of Bergen, Bergen, Norway.
FAU - Bleskestad, Inger Hjordis
AU  - Bleskestad IH
AD  - Department of Internal Medicine, Stavanger University Hospital, Stavanger, 
      Norway.
FAU - Skadberg, Oyvind
AU  - Skadberg O
AD  - Department of Medical Biochemistry, Stavanger University Hospital, Stavanger, 
      Norway.
FAU - Goransson, Lasse Gunnar
AU  - Goransson LG
AD  - Department of Internal Medicine, Stavanger University Hospital, Stavanger, 
      Norway.
AD  - Department of Clinical Medicine, University of Bergen, Bergen, Norway.
FAU - Okland, Inger
AU  - Okland I
AD  - Department of Obstetrics and Gynecology, Stavanger University Hospital, 
      Stavanger, Norway.
AD  - Department of Caring and Ethics, University of Stavanger, Stavanger, Norway.
LA  - eng
PT  - Journal Article
DEP - 20220211
PL  - England
TA  - Scand J Clin Lab Invest
JT  - Scandinavian journal of clinical and laboratory investigation
JID - 0404375
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Serum Albumin)
RN  - 0 (Glycated Serum Albumin)
SB  - IM
MH  - Blood Glucose/analysis
MH  - Chromatography, Liquid
MH  - *Diabetes, Gestational/diagnosis
MH  - Female
MH  - Glycated Hemoglobin/analysis
MH  - Glycation End Products, Advanced
MH  - Humans
MH  - Parity
MH  - Pregnancy
MH  - Serum Albumin
MH  - Tandem Mass Spectrometry
MH  - Glycated Serum Albumin
OTO - NOTNLM
OT  - Reference values
OT  - gestational diabetes
OT  - glycated albumin
OT  - glycated hemoglobin A1c
OT  - liquid chromatography
OT  - mass spectrometry
EDAT- 2022/02/12 06:00
MHDA- 2022/04/13 06:00
CRDT- 2022/02/11 17:10
PHST- 2022/02/12 06:00 [pubmed]
PHST- 2022/04/13 06:00 [medline]
PHST- 2022/02/11 17:10 [entrez]
AID - 10.1080/00365513.2022.2033827 [doi]
PST - ppublish
SO  - Scand J Clin Lab Invest. 2022 Apr;82(2):123-131. doi: 
      10.1080/00365513.2022.2033827. Epub 2022 Feb 11.