PMID- 35150127
OWN - NLM
STAT- MEDLINE
DCOM- 20220429
LR  - 20220716
IS  - 1758-0463 (Electronic)
IS  - 1758-0463 (Linking)
VI  - 2022
DP  - 2022 Feb 12
TI  - GNIFdb: a neoantigen intrinsic feature database for glioma.
LID - 10.1093/database/baac004 [doi]
LID - baac004
AB  - ABSTRACT: Neoantigens are mutation-containing immunogenic peptides from tumor 
      cells. Neoantigen intrinsic features are neoantigens' sequence-associated 
      features characterized by different amino acid descriptors and physical-chemical 
      properties, which have a crucial function in prioritization of neoantigens with 
      immunogenic potentials and predicting patients with better survival. Different 
      intrinsic features might have functions to varying degrees in evaluating 
      neoantigens' potentials of immunogenicity. Identification and comparison of 
      intrinsic features among neoantigens are particularly important for developing 
      neoantigen-based personalized immunotherapy. However, there is still no public 
      repository to host the intrinsic features of neoantigens. Therefore, we developed 
      GNIFdb, a glioma neoantigen intrinsic feature database specifically designed for 
      hosting, exploring and visualizing neoantigen and intrinsic features. The 
      database provides a comprehensive repository of computationally predicted Human 
      leukocyte antigen class I (HLA-I) restricted neoantigens and their intrinsic 
      features; a systematic annotation of neoantigens including sequence, 
      neoantigen-associated mutation, gene expression, glioma prognosis, HLA-I subtype 
      and binding affinity between neoantigens and HLA-I; and a genome browser to 
      visualize them in an interactive manner. It represents a valuable resource for 
      the neoantigen research community and is publicly available at 
      http://www.oncoimmunobank.cn/index.php. DATABASE URL: 
      http://www.oncoimmunobank.cn/index.php.
CI  - (c) The Author(s) 2022. Published by Oxford University Press.
FAU - Li, Wendong
AU  - Li W
AD  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, 
      Beijing Advanced Innovation Centre for Biomedical Engineering, School of 
      Engineering Medicine, School of Biological Science and Medical Engineering, 
      Beihang University, No.37 Xueyuan Road, Haidian District, Beijing 100083, P. R. 
      China.
FAU - Sun, Ting
AU  - Sun T
AD  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, 
      Beijing Advanced Innovation Centre for Biomedical Engineering, School of 
      Engineering Medicine, School of Biological Science and Medical Engineering, 
      Beihang University, No.37 Xueyuan Road, Haidian District, Beijing 100083, P. R. 
      China.
FAU - Li, Muyang
AU  - Li M
AD  - Department of Plant Genetics and Breeding, State Key Laboratory of Plant 
      Physiology and Biochemistry & National Maize Improvement Center, China 
      Agricultural University, No.17 Qinghua East Road, Haidian District, Beijing 
      100193, P. R. China.
FAU - He, Yufei
AU  - He Y
AD  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, 
      Beijing Advanced Innovation Centre for Biomedical Engineering, School of 
      Engineering Medicine, School of Biological Science and Medical Engineering, 
      Beihang University, No.37 Xueyuan Road, Haidian District, Beijing 100083, P. R. 
      China.
FAU - Li, Lin
AU  - Li L
AD  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, 
      Beijing Advanced Innovation Centre for Biomedical Engineering, School of 
      Engineering Medicine, School of Biological Science and Medical Engineering, 
      Beihang University, No.37 Xueyuan Road, Haidian District, Beijing 100083, P. R. 
      China.
FAU - Wang, Lu
AU  - Wang L
AD  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, 
      Beijing Advanced Innovation Centre for Biomedical Engineering, School of 
      Engineering Medicine, School of Biological Science and Medical Engineering, 
      Beihang University, No.37 Xueyuan Road, Haidian District, Beijing 100083, P. R. 
      China.
FAU - Wang, Haoyu
AU  - Wang H
AD  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, 
      Beijing Advanced Innovation Centre for Biomedical Engineering, School of 
      Engineering Medicine, School of Biological Science and Medical Engineering, 
      Beihang University, No.37 Xueyuan Road, Haidian District, Beijing 100083, P. R. 
      China.
FAU - Li, Jing
AU  - Li J
AD  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, 
      Beijing Advanced Innovation Centre for Biomedical Engineering, School of 
      Engineering Medicine, School of Biological Science and Medical Engineering, 
      Beihang University, No.37 Xueyuan Road, Haidian District, Beijing 100083, P. R. 
      China.
FAU - Wen, Hao
AU  - Wen H
AD  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, 
      Beijing Advanced Innovation Centre for Biomedical Engineering, School of 
      Engineering Medicine, School of Biological Science and Medical Engineering, 
      Beihang University, No.37 Xueyuan Road, Haidian District, Beijing 100083, P. R. 
      China.
FAU - Liu, Yong
AU  - Liu Y
AD  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, 
      Beijing Advanced Innovation Centre for Biomedical Engineering, School of 
      Engineering Medicine, School of Biological Science and Medical Engineering, 
      Beihang University, No.37 Xueyuan Road, Haidian District, Beijing 100083, P. R. 
      China.
FAU - Chen, Yifan
AU  - Chen Y
AD  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, 
      Beijing Advanced Innovation Centre for Biomedical Engineering, School of 
      Engineering Medicine, School of Biological Science and Medical Engineering, 
      Beihang University, No.37 Xueyuan Road, Haidian District, Beijing 100083, P. R. 
      China.
FAU - Fan, Yubo
AU  - Fan Y
AD  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, 
      Beijing Advanced Innovation Centre for Biomedical Engineering, School of 
      Engineering Medicine, School of Biological Science and Medical Engineering, 
      Beihang University, No.37 Xueyuan Road, Haidian District, Beijing 100083, P. R. 
      China.
FAU - Xin, Beibei
AU  - Xin B
AD  - Department of Plant Genetics and Breeding, State Key Laboratory of Plant 
      Physiology and Biochemistry & National Maize Improvement Center, China 
      Agricultural University, No.17 Qinghua East Road, Haidian District, Beijing 
      100193, P. R. China.
FAU - Zhang, Jing
AU  - Zhang J
AUID- ORCID: 0000-0001-8549-3286
AD  - Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, 
      Beijing Advanced Innovation Centre for Biomedical Engineering, School of 
      Engineering Medicine, School of Biological Science and Medical Engineering, 
      Beihang University, No.37 Xueyuan Road, Haidian District, Beijing 100083, P. R. 
      China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Database (Oxford)
JT  - Database : the journal of biological databases and curation
JID - 101517697
RN  - 0 (Antigens, Neoplasm)
SB  - IM
MH  - Antigens, Neoplasm/genetics/metabolism
MH  - Genome
MH  - *Glioma/genetics
MH  - Humans
MH  - Immunotherapy
MH  - Mutation
MH  - *Neoplasms/genetics
PMC - PMC9216533
EDAT- 2022/02/13 06:00
MHDA- 2022/04/30 06:00
PMCR- 2022/02/12
CRDT- 2022/02/12 08:33
PHST- 2021/09/08 00:00 [received]
PHST- 2022/01/06 00:00 [revised]
PHST- 2022/01/29 00:00 [accepted]
PHST- 2022/02/12 08:33 [entrez]
PHST- 2022/02/13 06:00 [pubmed]
PHST- 2022/04/30 06:00 [medline]
PHST- 2022/02/12 00:00 [pmc-release]
AID - 6527499 [pii]
AID - baac004 [pii]
AID - 10.1093/database/baac004 [doi]
PST - ppublish
SO  - Database (Oxford). 2022 Feb 12;2022:baac004. doi: 10.1093/database/baac004.