PMID- 35152352
OWN - NLM
STAT- MEDLINE
DCOM- 20220623
LR  - 20220623
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 29
IP  - 30
DP  - 2022 Jun
TI  - Effect of PM2.5 exposure on gestational hypertension, fetal size in 
      preeclampsia-like rats.
PG  - 45808-45820
LID - 10.1007/s11356-021-18233-4 [doi]
AB  - Studies have shown intriguing associations between gestational PM(2.5) exposure 
      and preeclampsia (PE), as well as fetal growth restriction (FGR). This study 
      investigated the impact of PM(2.5) exposure on gestational hypertension and fetal 
      outcome in a preeclampsia-like rat model. Pregnant Sprague Dawley rats were 
      exposed to either filtered (FA) or PM(2.5)-contaminated air during the whole 
      pregnancy period. A PE-like rat model was established by intraperitoneal 
      injection of L-NAME (300 mg/kg) from gestational day (GD) 12 to until GD20. 
      Systolic blood pressure (SBP), weight gain, pup weight and placental weight were 
      measured. The percentages of rat Treg/Th17 cells and Th17-related cytokines were 
      examined by flow cytometry. Gene expression profiles were analyzed by microarray, 
      and the expression of differentially expressed genes was validated by qRT-PCR. 
      The results showed that maternal PM(2.5) exposure had no effect on SBP but was 
      associated with low birth weight (LBW) and a higher labyrinth/basal zone ratio. 
      The percentages of splenic Th17 cells from the PM(2.5) group of PE-like rats were 
      higher than those from the FA or PM(2.5) groups of healthy controls. A 
      significantly decreased Treg/Th17 cell ratio was found in the PM(2.5) group of 
      PE-like rats. The mRNA expression of Foxp3 was downregulated, while the mRNA 
      expression of RORalpha and RORgammatau was upregulated after PM(2.5) exposure. Furthermore, 
      we observed that both the mRNA and protein levels of TNF-a, CCL2, CCL3 and CCR1 
      increased in the PM(2.5) groups. Our study suggested that systemic inflammation 
      may contribute to the development of FGR associated with PM(2.5) exposure 
      throughout pregnancy.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Gao, Jie
AU  - Gao J
AD  - Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, Capital 
      Medical University, Beijing, China.
AD  - Department of Obstetrics and Gynecology, Beijing Luhe Hospital, Capital Medical 
      University, Beijing, China.
FAU - Luo, Mei
AU  - Luo M
AD  - Central Laboratory, Beijing Luhe Hospital, Capital Medical University, Beijing, 
      China.
FAU - Zhao, Shuo
AU  - Zhao S
AD  - Department of Obstetrics and Gynecology, Beijing Luhe Hospital, Capital Medical 
      University, Beijing, China.
FAU - Wang, Hailing
AU  - Wang H
AD  - Department of Obstetrics and Gynecology, Beijing Luhe Hospital, Capital Medical 
      University, Beijing, China.
FAU - Li, Xuan
AU  - Li X
AD  - Department of Obstetrics and Gynecology, Beijing Luhe Hospital, Capital Medical 
      University, Beijing, China.
FAU - Xu, Pili
AU  - Xu P
AD  - Department of Obstetrics and Gynecology, Beijing Luhe Hospital, Capital Medical 
      University, Beijing, China.
FAU - Ma, Wei
AU  - Ma W
AD  - Department of Obstetrics and Gynecology, Beijing Luhe Hospital, Capital Medical 
      University, Beijing, China.
FAU - Liu, Chongdong
AU  - Liu C
AD  - Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, Capital 
      Medical University, Beijing, China. liuchongdong@ccmu.edu.cn.
LA  - eng
GR  - KJ2019CX014-12/Science and Technology Commission of Tongzhou District Foundation/
GR  - KJ2020CX006-01/Science and Technology Commission of Tongzhou District Foundation/
PT  - Journal Article
DEP - 20220212
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Air Pollutants)
RN  - 0 (Particulate Matter)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - *Air Pollutants/analysis/toxicity
MH  - Animals
MH  - Female
MH  - Humans
MH  - *Hypertension, Pregnancy-Induced
MH  - Maternal Exposure
MH  - Particulate Matter/analysis/toxicity
MH  - Placenta/chemistry
MH  - *Pre-Eclampsia
MH  - Pregnancy
MH  - RNA, Messenger
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Fine particulate matter
OT  - Low birth weight
OT  - Preeclampsia
OT  - Systemic inflammation
EDAT- 2022/02/14 06:00
MHDA- 2022/06/24 06:00
CRDT- 2022/02/13 20:37
PHST- 2021/09/08 00:00 [received]
PHST- 2021/12/16 00:00 [accepted]
PHST- 2022/02/14 06:00 [pubmed]
PHST- 2022/06/24 06:00 [medline]
PHST- 2022/02/13 20:37 [entrez]
AID - 10.1007/s11356-021-18233-4 [pii]
AID - 10.1007/s11356-021-18233-4 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2022 Jun;29(30):45808-45820. doi: 
      10.1007/s11356-021-18233-4. Epub 2022 Feb 12.