PMID- 35152553 OWN - NLM STAT- MEDLINE DCOM- 20221107 LR - 20231102 IS - 1751-7893 (Electronic) IS - 1751-7885 (Print) IS - 1751-7885 (Linking) VI - 16 IP - 11 DP - 2022 Nov TI - Longitudinal impact of trauma in the North American Prodrome Longitudinal Study-3. PG - 1211-1216 LID - 10.1111/eip.13270 [doi] AB - AIM: Individuals at clinical high risk (CHR) for psychosis have been shown to experience more trauma than the general population. However, although the effects of trauma appear to impact some symptoms it does not seem to increase the risk of transition to psychosis. The aim of this article was to examine the prevalence of trauma, and its association with longitudinal clinical and functional outcomes in a large sample of CHR individuals. METHODS: From the North American Prodrome Longitudinal Study-3 (NAPLS-3) 690 CHR individuals and 91 healthy controls from nine study sites between 2015 and 2018 were assessed. Historical trauma experiences were captured at baseline. Participants completed longitudinal assessments measuring clinical outcomes including positive and negative symptoms, depression, social and role functioning and assessing transition to psychosis. RESULTS: From the 690 CHR participants and 96 healthy controls, 343 (49.6%) and 15 (15.6%), respectively, reported a history of trauma (p < .001). Emotional neglect (70.3%) was the most commonly reported type of trauma, followed by psychological abuse (57.4%). Among CHR participants, time to transition to psychosis was not associated with trauma. Baseline depression and suspiciousness/persecutory ideas were statistically significantly different between CHR individuals who did or did not experience trauma. However, when examining clinical and functional outcomes over 12-months of follow-up, there were no differences between those who experienced trauma and those who did not. CONCLUSION: Overall, trauma is a significantly prevalent among CHR individuals. The effects of trauma on transition and longitudinal clinical and functional outcomes were not significant. CI - (c) 2022 John Wiley & Sons Australia, Ltd. FAU - Farris, Megan S AU - Farris MS AUID- ORCID: 0000-0003-0640-9512 AD - Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. FAU - Braun, Amy AU - Braun A AUID- ORCID: 0000-0002-6116-3597 AD - Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. FAU - Liu, Lu AU - Liu L AD - Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. FAU - Bearden, Carrie E AU - Bearden CE AD - Departments of Psychiatry and Biobehavioral Sciences and Psychology, UCLA, Los Angeles, California, USA. FAU - Cadenhead, Kristin S AU - Cadenhead KS AD - Department of Psychiatry, UCSD, San Diego, California, USA. FAU - Cornblatt, Barbara A AU - Cornblatt BA AD - Department of Psychiatry, Zucker Hillside Hospital, Long Island, New York, USA. FAU - Keshavan, Matcheri AU - Keshavan M AD - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Mathalon, Daniel H AU - Mathalon DH AD - Department of Psychiatry, UCSF, and SFVA Medical Center, San Francisco, California, USA. FAU - McGlashan, Thomas H AU - McGlashan TH AD - Department of Psychiatry, Yale University, New Haven, Connecticut, USA. FAU - Perkins, Diana O AU - Perkins DO AD - Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina, USA. FAU - Stone, William S AU - Stone WS AD - Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Tsuang, Ming T AU - Tsuang MT AD - Department of Psychiatry, UCSD, San Diego, California, USA. AD - Institute of Genomic Medicine, University of California, La Jolla, California, USA. FAU - Walker, Elaine F AU - Walker EF AD - Departments of Psychology and Psychiatry, Emory University, Atlanta, Georgia, USA. FAU - Woods, Scott W AU - Woods SW AD - Department of Psychiatry, Yale University, New Haven, Connecticut, USA. FAU - Cannon, Tyrone D AU - Cannon TD AD - Department of Psychology, Yale University, New Haven, Connecticut, USA. FAU - Addington, Jean AU - Addington J AUID- ORCID: 0000-0002-8298-0756 AD - Department of Psychiatry, Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. LA - eng GR - UL1 TR001863/TR/NCATS NIH HHS/United States GR - U01 MH081902/MH/NIMH NIH HHS/United States GR - U01 MH081988/MH/NIMH NIH HHS/United States GR - U01 MH076989/MH/NIMH NIH HHS/United States GR - U01 MH081928/MH/NIMH NIH HHS/United States GR - U01 MH082022/MH/NIMH NIH HHS/United States GR - U01 MH081984/MH/NIMH NIH HHS/United States GR - U01 MH081857/MH/NIMH NIH HHS/United States GR - U01 MH082004/MH/NIMH NIH HHS/United States GR - U01 MH081944/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220213 PL - Australia TA - Early Interv Psychiatry JT - Early intervention in psychiatry JID - 101320027 SB - IM MH - Humans MH - *Prodromal Symptoms MH - Longitudinal Studies MH - *Psychotic Disorders/psychology MH - North America/epidemiology PMC - PMC9374846 MID - NIHMS1773884 OTO - NOTNLM OT - clinical high risk OT - clinical outcomes OT - depression OT - transition to psychosis OT - trauma COIS- Conflicts of Interest Authors declare they have no conflict of interest with respect to this study. EDAT- 2022/02/14 06:00 MHDA- 2022/11/08 06:00 PMCR- 2023/11/01 CRDT- 2022/02/13 20:38 PHST- 2021/11/03 00:00 [revised] PHST- 2021/04/19 00:00 [received] PHST- 2022/01/18 00:00 [accepted] PHST- 2022/02/14 06:00 [pubmed] PHST- 2022/11/08 06:00 [medline] PHST- 2022/02/13 20:38 [entrez] PHST- 2023/11/01 00:00 [pmc-release] AID - 10.1111/eip.13270 [doi] PST - ppublish SO - Early Interv Psychiatry. 2022 Nov;16(11):1211-1216. doi: 10.1111/eip.13270. Epub 2022 Feb 13.