PMID- 35153491
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220501
IS  - 1178-6965 (Print)
IS  - 1178-6965 (Electronic)
IS  - 1178-6965 (Linking)
VI  - 15
DP  - 2022
TI  - Role of Thymus and Activation-Regulated Chemokine in Allergic Asthma.
PG  - 157-167
LID - 10.2147/JAA.S351720 [doi]
AB  - BACKGROUND: Asthma is a chronic inflammatory airway disease characterized by the 
      predominant infiltration of inflammatory cells in the airways. Thymus and 
      activation-regulated chemokine/C-C motif chemokine 17 (TARC/CCL17) is a chemokine 
      responsible for trafficking T helper 2 cells into sites of allergic inflammation. 
      OBJECTIVE: To validate the role of TARC in association with clinical and 
      inflammatory parameters in adult asthmatics. METHODS: We enrolled 128 asthmatic 
      patients and 70 healthy controls (HCs). Asthma-related clinical and laboratory 
      parameters, including lung function and eosinophil counts, were measured. Serum 
      levels of TARC, free immunoglobulin E (IgE), and eosinophil-derived neurotoxin 
      (EDN) were determined by using enzyme-linked immunosorbent assay; serum total IgE 
      level was measured using ImmunoCAP. The levels of inflammatory lipid mediators, 
      such as leukotriene E4 (LTE4), 15-hydroxyeicosatetraenoic acid (15-HETE), 
      thromboxane B2 (TXB2), and prostaglandin F2alpha (PGF2alpha), were measured by liquid 
      chromatography-tandem mass spectrometry. RESULTS: Serum TARC levels are 
      significantly higher in asthmatics than in HCs and in allergic asthmatics than in 
      HCs (P < 0.010 for all), with significantly negative correlations between serum 
      TARC levels and FEV(1)%/MMEF% values (r = -0.314, r = -0.268, P < 0.050 for 
      both). The patients with higher serum TARC levels had higher levels of serum 
      total and free IgE levels (P < 0.050 for both) with positive correlations to 
      serum levels of EDN, TXB2, and 15-HETE (r = 0.233, r = 0.264, and r = 0.223, 
      respectively, P < 0.050 for all). CONCLUSION: We suggest the role of TARC in 
      allergic asthma via contributing to mast cell and eosinophilic inflammation.
CI  - (c) 2022 Luu Quoc et al.
FAU - Luu Quoc, Quang
AU  - Luu Quoc Q
AUID- ORCID: 0000-0003-2183-8171
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, South Korea.
FAU - Moon, Ji-Young
AU  - Moon JY
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, South Korea.
FAU - Lee, Dong-Hyun
AU  - Lee DH
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, South Korea.
FAU - Ban, Ga-Young
AU  - Ban GY
AUID- ORCID: 0000-0002-7961-742X
AD  - Department of Pulmonary, Allergy, and Critical Care Medicine, Kangdong Sacred 
      Heart Hospital, Hallym University College of Medicine Institute for Life 
      Sciences, Chuncheon, South Korea.
FAU - Kim, Seung-Hyun
AU  - Kim SH
AD  - Translational Research Laboratory for Inflammatory Disease, Clinical Trial 
      Center, Ajou University Medical Center, Suwon, South Korea.
FAU - Park, Hae-Sim
AU  - Park HS
AUID- ORCID: 0000-0003-2614-0303
AD  - Department of Allergy and Clinical Immunology, Ajou University School of 
      Medicine, Suwon, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20220205
PL  - New Zealand
TA  - J Asthma Allergy
JT  - Journal of asthma and allergy
JID - 101543450
PMC - PMC8828566
OTO - NOTNLM
OT  - IgE
OT  - T cells
OT  - allergic asthma
OT  - asthma
OT  - eosinophils
OT  - mast cells
OT  - thymus and activation-regulated chemokine
COIS- The authors report no conflicts of interest for this work and that there are no 
      financial or other issues that might lead to conflicts of interest.
EDAT- 2022/02/15 06:00
MHDA- 2022/02/15 06:01
PMCR- 2022/02/05
CRDT- 2022/02/14 05:28
PHST- 2021/11/30 00:00 [received]
PHST- 2022/01/22 00:00 [accepted]
PHST- 2022/02/14 05:28 [entrez]
PHST- 2022/02/15 06:00 [pubmed]
PHST- 2022/02/15 06:01 [medline]
PHST- 2022/02/05 00:00 [pmc-release]
AID - 351720 [pii]
AID - 10.2147/JAA.S351720 [doi]
PST - epublish
SO  - J Asthma Allergy. 2022 Feb 5;15:157-167. doi: 10.2147/JAA.S351720. eCollection 
      2022.