PMID- 35154524
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220501
IS  - 1734-1922 (Print)
IS  - 1896-9151 (Electronic)
IS  - 1734-1922 (Linking)
VI  - 18
IP  - 1
DP  - 2022
TI  - Factors associated with gastro-duodenal ulcer in compensated type 2 diabetic 
      patients: a Romanian single-center study.
PG  - 45-51
LID - 10.5114/aoms/93098 [doi]
AB  - INTRODUCTION: Helicobacter pylori infection is accepted as the leading cause of 
      chronic gastritis, ulcer disease and gastric cancer, with an important impact on 
      health care burden, especially in countries with a high prevalence of infection. 
      The aim of the study was to investigate the influence of H. pylori infection, 
      medication, associated medical conditions or social habits on endoscopic ulcer 
      occurrence in the compensated type 2 diabetic population. MATERIAL AND METHODS: 
      Two hundred and sixty type 2 diabetic patients investigated on endoscopy (57 
      patients with peptic ulcer and 203 controls) with a complete set of biopsies, 
      demographic and medical data were enrolled. RESULTS: On univariate regression 
      analysis, H. pylori infection (42.1% vs. 35.5%, p = 0.359) or a history of peptic 
      ulcer (61.4% vs. 61.6%, p = 0.981) was not a predictor for ulcer on endoscopy in 
      the diabetic population, and heartburn was more frequent in diabetics without 
      ulcer (21.2% vs. 8.8%, p = 0.033). Anemia was the best predictor for ulcer on 
      endoscopy in both diabetics with (p < 0.001, OR = 4.77, 95% CI: 2.02-11.28) and 
      without (p = 0.027, OR = 2.76, 95% CI: 1.10-6.91) chronic proton pump inhibitor 
      (PPI) therapy. In diabetic patients on PPI more than 1 month anticoagulants - 
      acenocoumarol or low-weight molecular heparin (p = 0.038, OR = 2.37, 95% CI: 
      1.04-5.40), low-dose aspirin 75-125 mg/day (p = 0.029, OR = 2.61, 95% CI: 
      1.08-6.28) and alcohol consumption (p = 0.015, OR = 2.70, 95% CI: 1.19-6.13) were 
      predictors for ulcer on endoscopy. CONCLUSIONS: In diabetic patients, anemia is 
      the most important predictor for ulcer on endoscopy, but not H. pylori or 
      digestive symptoms, while low-dose aspirin or anticoagulant therapy and alcohol 
      consumption are the most important predictors for ulcer in diabetics on chronic 
      proton pump inhibitor therapy.
CI  - Copyright: (c) 2021 Termedia & Banach.
FAU - Negovan, Anca
AU  - Negovan A
AD  - Department of Clinical Science-Internal Medicine, "George Emil Palade" University 
      of Medicine, Pharmacy, Science, and Technology of Targu Mures, Mures, Romania.
FAU - Banescu, Claudia
AU  - Banescu C
AD  - Genetics Laboratory, Center for Advanced Medical and Pharmaceutical Research, 
      "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of 
      Targu Mures, Targu Mures, Romania.
FAU - Pantea, Monica
AU  - Pantea M
AD  - Department of Clinical Science-Internal Medicine, "George Emil Palade" University 
      of Medicine, Pharmacy, Science, and Technology of Targu Mures, Mures, Romania.
FAU - Simona, Bataga
AU  - Simona B
AD  - Department of Clinical Science-Internal Medicine, "George Emil Palade" University 
      of Medicine, Pharmacy, Science, and Technology of Targu Mures, Mures, Romania.
FAU - Mocan, Simona
AU  - Mocan S
AD  - Pathology Department, Emergency County Hospital Targu Mures, Mures, Romania.
FAU - Iancu, Mihaela
AU  - Iancu M
AD  - Department of Medical Informatics and Biostatistics, "Iuliu Hatieganu" University 
      of Medicine and Pharmacy, Cluj-Napoca, Romania.
LA  - eng
PT  - Journal Article
DEP - 20210108
PL  - Poland
TA  - Arch Med Sci
JT  - Archives of medical science : AMS
JID - 101258257
PMC - PMC8826883
OTO - NOTNLM
OT  - Helicobacter pylori
OT  - alcohol
OT  - anticoagulant
OT  - aspirin
OT  - proton pump inhibitors
COIS- The authors declare no conflict of interest.
EDAT- 2022/02/15 06:00
MHDA- 2022/02/15 06:01
PMCR- 2021/01/08
CRDT- 2022/02/14 05:31
PHST- 2018/02/25 00:00 [received]
PHST- 2018/07/10 00:00 [accepted]
PHST- 2022/02/14 05:31 [entrez]
PHST- 2022/02/15 06:00 [pubmed]
PHST- 2022/02/15 06:01 [medline]
PHST- 2021/01/08 00:00 [pmc-release]
AID - 93098 [pii]
AID - 10.5114/aoms/93098 [doi]
PST - epublish
SO  - Arch Med Sci. 2021 Jan 8;18(1):45-51. doi: 10.5114/aoms/93098. eCollection 2022.