PMID- 35154608
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220501
IS  - 2008-2258 (Print)
IS  - 2008-4234 (Electronic)
IS  - 2008-2258 (Linking)
VI  - 14
IP  - Suppl1
DP  - 2021 Fall
TI  - Assessment of common and differentially expressed proteins between diabetes 
      mellitus and fatty liver disease: a network analysis.
PG  - S94-S101
AB  - AIM: This study aimed to introduce the main biomarkers related to NFLD and 
      diabetes II to determine common pathogenic and metabolite factors linking NFLD to 
      diabetes II. BACKGROUND: Nonalcoholic fatty liver disease (NFLD) is chronic 
      hepatic failure with a broad range of hepatic disorders. NFLD and diabetes type 2 
      coexist regularly to drive adverse outcomes such as hepatocellular carcinoma and 
      vascular complications. METHODS: The proteins related to NFDL and diabetes 
      mellitus were extracted from String database. Proteins related to each disease 
      were included in protein-protein interaction networks in Cytoscape software. 
      Obtained networks were analyzed using Cytoscape network analyzer. The central 
      nodes were determined as top hubs based on degree value. The top hubs related to 
      NFLD and diabetes mellites were compared. RESULTS: In total, 200 proteins related 
      to NFDL and diabetes mellitus were found separately in String database and 
      connected through undirected edges in individual networks. Central nodes based on 
      degree value were determined for each disease. Ten percent of top nodes were 
      selected based on degree value as the 20 top hubs for each disease. Target common 
      hub proteins between NFDL and diabetes mellitus comprised INS, AKT1, ALB, PPARG, 
      IL6, GPDPH, LEP, TNF, ADIPOQ, IGF1, TP53, MAPK3, and SIRT1. CONCLUSION: According 
      to the results, 13 common and 14 discriminatory central dysregulated proteins 
      were determined for NAFLD and diabetes mellitus.
CI  - (c)2021 RIGLD, Research Institute for Gastroenterology and Liver Diseases.
FAU - Saki, Kourosh
AU  - Saki K
AD  - Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti 
      University of Medical Sciences, Tehran, Iran.
FAU - Mansouri, Vahid
AU  - Mansouri V
AD  - Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti 
      University of Medical Sciences, Tehran, Iran.
FAU - Abdi, Saeed
AU  - Abdi S
AD  - Gastroenterology and Liver Diseases Research Center, Research Institute for 
      Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Fathi, Mohammad
AU  - Fathi M
AD  - Critical Care Quality Improvement Research Center, Faculty of Paramedical 
      Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Razzaghi, Zahra
AU  - Razzaghi Z
AD  - Laser Application in Medical Sciences Research Center, Shahid Beheshti University 
      of Medical Sciences, Tehran, Iran.
FAU - Haghazali, Mehrdad
AU  - Haghazali M
AD  - Rajaie Cardiovascular Medical and Research Center, Iran University of Medical 
      Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - Gastroenterol Hepatol Bed Bench
JT  - Gastroenterology and hepatology from bed to bench
JID - 101525875
PMC - PMC8817743
OTO - NOTNLM
OT  - Bioinformatics
OT  - Biomarkers
OT  - Diabetes mellitus
OT  - Network analysis
OT  - Nonalcoholic fatty liver disease
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/02/15 06:00
MHDA- 2022/02/15 06:01
PMCR- 2021/09/01
CRDT- 2022/02/14 05:32
PHST- 2021/06/29 00:00 [received]
PHST- 2021/09/11 00:00 [accepted]
PHST- 2022/02/14 05:32 [entrez]
PHST- 2022/02/15 06:00 [pubmed]
PHST- 2022/02/15 06:01 [medline]
PHST- 2021/09/01 00:00 [pmc-release]
AID - GHFBB-14-S94 [pii]
PST - ppublish
SO  - Gastroenterol Hepatol Bed Bench. 2021 Fall;14(Suppl1):S94-S101.