PMID- 35155038
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220215
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 14
IP  - 2
DP  - 2022 Feb
TI  - Methazolamide Associated Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis in a 
      Female of Caucasian Descent.
PG  - e21864
LID - 10.7759/cureus.21864 [doi]
LID - e21864
AB  - Stevens-Johnson syndrome (SJS) is a potentially life-threatening cutaneous 
      disorder that is characterized by skin erosions. It lies on a spectrum of varying 
      severity with toxic epidermal necrolysis (TEN) being the most severe form. An 
      overlap of the syndromes is known as SJS/TEN. These disorders are most often 
      caused by a drug reaction, with anti-epileptic drugs and sulfonamide drugs as the 
      common offending agents. Rarely, the syndrome can be due to a reaction to 
      carbonic anhydrase inhibitors such as methazolamide. When present in association 
      with methazolamide, the syndrome has only been known to occur in patients of 
      Asian descent with human leukocyte antigen (HLA) mutations. We present a case of 
      methazolamide-associated Stevens-Johnson syndrome in a patient of Caucasian 
      descent.
CI  - Copyright (c) 2022, Baluch et al.
FAU - Baluch, Amarah
AU  - Baluch A
AD  - Internal Medicine, State University of New York Upstate Medical University, 
      Syracuse, USA.
FAU - Chohan, Moeed R
AU  - Chohan MR
AD  - Internal Medicine, State University of New York Upstate Medical University, 
      Syracuse, USA.
FAU - Warda, Katerina
AU  - Warda K
AD  - Internal Medicine, State University of New York Upstate Medical University, 
      Syracuse, USA.
FAU - Sippy, Rishab
AU  - Sippy R
AD  - Internal Medicine, State University of New York Upstate Medical University, 
      Syracuse, USA.
FAU - Sandhu, Jasmine
AU  - Sandhu J
AD  - Internal Medicine, State University of New York Upstate Medical University, 
      Syracuse, USA.
LA  - eng
PT  - Case Reports
DEP - 20220203
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC8815805
OTO - NOTNLM
OT  - cutaneous adverse drug reaction
OT  - hla
OT  - methazolamide
OT  - stevens johnson
OT  - toxic epidermal necrolysis
COIS- The authors have declared that no competing interests exist.
EDAT- 2022/02/15 06:00
MHDA- 2022/02/15 06:01
PMCR- 2022/02/03
CRDT- 2022/02/14 05:33
PHST- 2022/02/03 00:00 [accepted]
PHST- 2022/02/14 05:33 [entrez]
PHST- 2022/02/15 06:00 [pubmed]
PHST- 2022/02/15 06:01 [medline]
PHST- 2022/02/03 00:00 [pmc-release]
AID - 10.7759/cureus.21864 [doi]
PST - epublish
SO  - Cureus. 2022 Feb 3;14(2):e21864. doi: 10.7759/cureus.21864. eCollection 2022 Feb.