PMID- 35155781
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231105
IS  - 2378-8038 (Print)
IS  - 2378-8038 (Electronic)
IS  - 2378-8038 (Linking)
VI  - 7
IP  - 1
DP  - 2022 Feb
TI  - Efficacy of dual sublingual immunotherapy with Japanese cedar pollen and house 
      dust mite allergens in patients with allergic rhinitis sensitized to multiple 
      allergens.
PG  - 36-42
LID - 10.1002/lio2.740 [doi]
AB  - OBJECTIVE: In the present study, we examined the effects of dual sublingual 
      immunotherapy (SLIT) with Japanese cedar pollen (JCP) and house dust mite (HDM) 
      allergens on nasal symptoms during the peak pollen period (PPP) and in late fall 
      (LF) in patients with allergic rhinitis (AR) sensitized to both JCP and HDM. We 
      then compared the efficacy of dual-SLIT with JCP and HDM to that of mono-SLIT 
      with JCP at PPP. METHODS: Twenty-five bisensitized patients with AR who showed 
      positive serum specific immunoglobulin E (IgE) against both JCP and HDM were 
      enrolled. In dual-SLIT, 16 patients received JCP drops/tablets and HDM tablets 
      concurrently. In mono-SLIT with JCP, nine patients received JCP drops/tablets. 
      Nasal symptoms were scored on a 0-4 point scale. RESULTS: The nasal scores at PPP 
      and in LF in the bisensitized patients with AR who received dual-SLIT with JCP 
      and HDM in 2019 were significantly lower than those in the same patients who 
      received antihistamines only in 2018. The decrease in scores of nasal obstruction 
      at PPP from 2018 to 2019 in patients who received dual-SLIT was significantly 
      greater than those in patients who received mono-SLIT with JCP. Dual-SLIT was 
      well tolerated and only had mild adverse effects. CONCLUSION: These findings 
      suggest that dual-SLIT suppressed both JCP-induced seasonal and HDM-induced 
      perennial nasal symptoms in bisensitized patients with AR. Dual-SLIT was more 
      effective in suppressing nasal obstruction at PPP than mono-SLIT with JCP with 
      limitation of baseline characteristics not to be controlled between the two 
      groups, suggesting that dual-SLIT suppressed HDM-induced priming effects, thus 
      resulting in further suppression of nasal obstruction at PPP. LEVEL OF EVIDENCE: 
      3b, a case-controlled study.
CI  - (c) 2022 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley 
      Periodicals LLC on behalf of The Triological Society.
FAU - Fujii, Tatsuya
AU  - Fujii T
AD  - Department of Otolaryngology JA Kochi Hospital Nankoku Kochi Japan.
AD  - Department of Otolaryngology Institute of Biomedical Sciences, Tokushima 
      University Graduate School Kuramoto Tokushima Japan.
FAU - Kitamura, Yoshiaki
AU  - Kitamura Y
AUID- ORCID: 0000-0001-8705-9563
AD  - Department of Otolaryngology Institute of Biomedical Sciences, Tokushima 
      University Graduate School Kuramoto Tokushima Japan.
FAU - Kamimura, Seiichiro
AU  - Kamimura S
AUID- ORCID: 0000-0001-9269-9514
AD  - Department of Otolaryngology Institute of Biomedical Sciences, Tokushima 
      University Graduate School Kuramoto Tokushima Japan.
FAU - Ishitani, Keisuke
AU  - Ishitani K
AD  - Department of Otolaryngology Institute of Biomedical Sciences, Tokushima 
      University Graduate School Kuramoto Tokushima Japan.
FAU - Takeda, Noriaki
AU  - Takeda N
AUID- ORCID: 0000-0002-0817-5556
AD  - Department of Otolaryngology Institute of Biomedical Sciences, Tokushima 
      University Graduate School Kuramoto Tokushima Japan.
LA  - eng
PT  - Journal Article
DEP - 20220121
PL  - United States
TA  - Laryngoscope Investig Otolaryngol
JT  - Laryngoscope investigative otolaryngology
JID - 101684963
PMC - PMC8823165
OTO - NOTNLM
OT  - Japanese cedar pollen
OT  - allergic rhinitis
OT  - dual sublingual immunotherapy
OT  - house dust mite
COIS- The authors have no conflicts of interest to declare.
EDAT- 2022/02/15 06:00
MHDA- 2022/02/15 06:01
PMCR- 2022/01/21
CRDT- 2022/02/14 05:36
PHST- 2021/08/12 00:00 [received]
PHST- 2021/12/08 00:00 [revised]
PHST- 2022/01/08 00:00 [accepted]
PHST- 2022/02/14 05:36 [entrez]
PHST- 2022/02/15 06:00 [pubmed]
PHST- 2022/02/15 06:01 [medline]
PHST- 2022/01/21 00:00 [pmc-release]
AID - LIO2740 [pii]
AID - 10.1002/lio2.740 [doi]
PST - epublish
SO  - Laryngoscope Investig Otolaryngol. 2022 Jan 21;7(1):36-42. doi: 10.1002/lio2.740. 
      eCollection 2022 Feb.