PMID- 35155790
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231105
IS  - 2378-8038 (Print)
IS  - 2378-8038 (Electronic)
IS  - 2378-8038 (Linking)
VI  - 7
IP  - 1
DP  - 2022 Feb
TI  - Prognostic analysis and establishment of a nomogram in patients with 
      myoepithelial carcinoma of the salivary gland: A population-based study.
PG  - 125-134
LID - 10.1002/lio2.723 [doi]
AB  - BACKGROUND: Currently, the clinicopathological characteristics and prognosis of 
      myoepithelial carcinoma of salivary gland (MC-SG) have not been defined well. The 
      present study aimed to describe the clinicopathological characteristics and 
      prognosis of MC-SG patients. METHODS: The Surveillance, Epidemiology, and End 
      Results database was searched for all patients diagnosed with MC-SG between 1991 
      and 2016. The Kaplan-Meier method and log-rank tests were used to evaluate the 
      survival. Univariate and multivariate Cox regression analysis were used to 
      identify prognostic biomarkers for overall survival (OS) and disease-specific 
      survival (DSS). Furthermore, a prognostic nomogram was established, and its 
      predictive accuracy and discriminative ability were determined using the 
      concordance index (C-index). RESULTS: In total, 245 patients diagnosed with MC-SG 
      were identified. The median OS was 152.0 months, with 3-, 5-, and 10-year 
      survival rates of 79.8%, 69.2%, and 50.3%. The 3-, 5-, and 10-year DSS rates were 
      82.5%, 77.1%, and 61.9%, respectively. Regarding the treatment regimen, most 
      patients (92.2%) underwent surgery, and 103 patients (42.4%) received 
      postoperative radiotherapy. Surgery could significantly prolong OS and DSS 
      (p < .05), but postoperative radiotherapy did not significantly prolong OS and 
      DSS when compared with individuals receiving surgery alone (p > .05). 
      Multivariate Cox analysis revealed that T category (T4), lymph node metastasis 
      (N2), distant metastasis (M1), and poor differentiation were independent 
      unfavorable prognostic factors for OS and DSS. Older age (>62 years) was also 
      independently associated with OS. In addition, the C-index for the established 
      OS- and DSS-specific nomogram was 0.80 (95% CI: 0.72-0.88) and 0.82 (95% CI: 
      0.73-0.90). CONCLUSION: Age, tumor invasion, metastases, and pathological grade 
      were independently associated with prognosis of MC-SG patients, and the 
      prognostic nomogram of this rare disease was established.
CI  - (c) 2022 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley 
      Periodicals LLC on behalf of The Triological Society.
FAU - Liu, Ying
AU  - Liu Y
AUID- ORCID: 0000-0003-3951-1388
AD  - Center for Esthetic Dentistry Jinan Stomatological Hospital Jinan China.
FAU - Mi, Yong
AU  - Mi Y
AD  - Dental Laboratory Jinan Stomatological Hospital Jinan China.
FAU - Zhang, Li
AU  - Zhang L
AD  - Center for Esthetic Dentistry Jinan Stomatological Hospital Jinan China.
FAU - Gong, Qi
AU  - Gong Q
AD  - Center for Esthetic Dentistry Jinan Stomatological Hospital Jinan China.
FAU - Jiang, Tao
AU  - Jiang T
AD  - Center for Esthetic Dentistry Jinan Stomatological Hospital Jinan China.
LA  - eng
PT  - Journal Article
DEP - 20220104
PL  - United States
TA  - Laryngoscope Investig Otolaryngol
JT  - Laryngoscope investigative otolaryngology
JID - 101684963
PMC - PMC8823152
OTO - NOTNLM
OT  - SEER database
OT  - myoepithelial carcinoma
OT  - nomogram
OT  - prognosis
OT  - salivary gland tumor
COIS- The author declared no conflict of interest.
EDAT- 2022/02/15 06:00
MHDA- 2022/02/15 06:01
PMCR- 2022/01/04
CRDT- 2022/02/14 05:36
PHST- 2021/08/31 00:00 [received]
PHST- 2021/10/26 00:00 [revised]
PHST- 2021/12/11 00:00 [accepted]
PHST- 2022/02/14 05:36 [entrez]
PHST- 2022/02/15 06:00 [pubmed]
PHST- 2022/02/15 06:01 [medline]
PHST- 2022/01/04 00:00 [pmc-release]
AID - LIO2723 [pii]
AID - 10.1002/lio2.723 [doi]
PST - epublish
SO  - Laryngoscope Investig Otolaryngol. 2022 Jan 4;7(1):125-134. doi: 
      10.1002/lio2.723. eCollection 2022 Feb.