PMID- 35156316
OWN - NLM
STAT- MEDLINE
DCOM- 20220405
LR  - 20220612
IS  - 1932-7005 (Electronic)
IS  - 1932-6254 (Linking)
VI  - 16
IP  - 4
DP  - 2022 Apr
TI  - 3D printed bioceramic scaffolds: Adjusting pore dimension is beneficial for 
      mandibular bone defects repair.
PG  - 409-421
LID - 10.1002/term.3287 [doi]
AB  - Bioceramic scaffolds for repairing mandibular bone defects have considerable 
      effects, whereas pore architecture in porous scaffolds on osteogenesis in 
      specific structures is still controversial. Herein 6 mol% magnesium-substituted 
      calcium silicate scaffolds were fabricated with similar porosity ( approximately 58%) but 
      different cylindrical pore dimensions (O 480, 600, and 720 mum) via digital light 
      processing-based three-dimensional (3D) printing technique. The mechanical 
      properties, bioactive ion release, and bio-dissolution of the bioceramic 
      scaffolds were evaluated in vitro, and the facilitation of scaffolds on bone 
      formation was investigated after implanting in vivo. The results showed that as 
      the pore dimension increased, the scaffolds indicated similar surface 
      microstructures, but their compressive strength was enhanced gradually. There was 
      no significant difference in vitro bio-dissolution between the 480 and 600 mum 
      groups, whereas the 720 mum group showed a much slower dissolution and ion 
      release. Interestingly, the two-dimensional/three-dimensional (2D/3D) micro-CT 
      reconstruction analysis of rabbits' mandibular bone defects model showed that the 
      600 mum group exhibited evidently higher ratio of the newly formed bone volume to 
      total volume (BV/TV) and trabecular number (Tb. N) values and lower ratio of the 
      scaffolds residual volume to total volume (RV/TV) compare to the other two sizes. 
      Furthermore, the histological analysis also revealed a considerably higher new 
      bone ingrowth rate in the 600 mum group than the other two groups at 4-12 weeks 
      post-implantation. Totally, it is proved from these experimental studies that the 
      DLP-based accurately fabricated calcium (Ca) silicate bioceramic scaffolds with 
      appropriate pore dimensions (i.e., 600 mum in pore size) are promising to guide 
      new bone ingrowth and thus accelerate the regeneration and repair of cranial 
      maxillofacial or periodontal bone defects.
CI  - (c) 2022 John Wiley & Sons Ltd.
FAU - Qin, Hongling
AU  - Qin H
AUID- ORCID: 0000-0002-7278-8568
AD  - Department of Periodontics, The Second Affiliated Hospital, Zhejiang University, 
      School of Medicine, Hangzhou, China.
FAU - Wei, Yingming
AU  - Wei Y
AD  - Department of Periodontics, The Second Affiliated Hospital, Zhejiang University, 
      School of Medicine, Hangzhou, China.
FAU - Han, Jiayin
AU  - Han J
AD  - Department of Periodontics, The Second Affiliated Hospital, Zhejiang University, 
      School of Medicine, Hangzhou, China.
FAU - Jiang, Xiaojian
AU  - Jiang X
AD  - Department of Periodontics, The Second Affiliated Hospital, Zhejiang University, 
      School of Medicine, Hangzhou, China.
FAU - Yang, Xianyan
AU  - Yang X
AD  - Bio-nanomaterials and Regenerative Medicine Research Division, 
      Zhejiang-California International Nanosystem Institute, Zhejiang University, 
      Hangzhou, China.
FAU - Wu, Yanmin
AU  - Wu Y
AD  - Department of Periodontics, The Second Affiliated Hospital, Zhejiang University, 
      School of Medicine, Hangzhou, China.
FAU - Gou, Zhongru
AU  - Gou Z
AD  - Bio-nanomaterials and Regenerative Medicine Research Division, 
      Zhejiang-California International Nanosystem Institute, Zhejiang University, 
      Hangzhou, China.
FAU - Chen, Lili
AU  - Chen L
AD  - Department of Periodontics, The Second Affiliated Hospital, Zhejiang University, 
      School of Medicine, Hangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220214
PL  - England
TA  - J Tissue Eng Regen Med
JT  - Journal of tissue engineering and regenerative medicine
JID - 101308490
SB  - IM
MH  - Animals
MH  - Bone Regeneration
MH  - *Osteogenesis
MH  - Porosity
MH  - Printing, Three-Dimensional
MH  - Rabbits
MH  - Skull/pathology
MH  - *Tissue Scaffolds/chemistry
OTO - NOTNLM
OT  - 3D printing
OT  - bone tissue
OT  - osteogenesis
OT  - pore dimension
OT  - porous scaffolds
EDAT- 2022/02/15 06:00
MHDA- 2022/04/06 06:00
CRDT- 2022/02/14 05:40
PHST- 2021/12/27 00:00 [revised]
PHST- 2021/10/26 00:00 [received]
PHST- 2022/01/26 00:00 [accepted]
PHST- 2022/02/15 06:00 [pubmed]
PHST- 2022/04/06 06:00 [medline]
PHST- 2022/02/14 05:40 [entrez]
AID - 10.1002/term.3287 [doi]
PST - ppublish
SO  - J Tissue Eng Regen Med. 2022 Apr;16(4):409-421. doi: 10.1002/term.3287. Epub 2022 
      Feb 14.