PMID- 35157936
OWN - NLM
STAT- MEDLINE
DCOM- 20220322
LR  - 20220322
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 301
DP  - 2022 May 15
TI  - Early life PCB138 exposure induces kidney injury secondary to hyperuricemia in 
      male mice.
PG  - 118977
LID - S0269-7491(22)00191-9 [pii]
LID - 10.1016/j.envpol.2022.118977 [doi]
AB  - Polychlorinated biphenyls (PCBs) are a class of persistent organic pollutants 
      (POPs) that have adverse effects on human health. However, the long-term health 
      effects and potential mechanism of neonatal exposure to PCBs are still unclear. 
      In this study, nursing male mice exposed to PCB138 at 0.5, 5, and 50 mug/kg body 
      weight (bw) from postnatal day (PND) 3 to PND 21 exhibited increased serum uric 
      acid levels and liver uric acid synthase activity at 210 days of age. We also 
      found an increased kidney somatic index in the 50 mug/kg group and kidney fibrosis 
      in the 5 and 50 mug/kg groups. Mechanistically, PCB138 induced mitochondrial 
      dysfunction and endoplasmic reticulum (ER) stress, which might have led to 
      inflammatory responses, such as activation of the NF-kappaB (nuclear factor kappa-B) 
      and NLRP3 (NOD-like receptor protein 3) pathways. The inflammatory response might 
      regulate renal fibrosis and hypertrophy. In summary, this study reports a 
      long-term effect of neonatal PCB exposure on uric acid metabolism and secondary 
      nephrotoxicity and clarifies the underlying mechanism. Our work also indicates 
      that early life pollutant exposure may be an important cause of diseases later in 
      life.
CI  - Copyright (c) 2022 Elsevier Ltd. All rights reserved.
FAU - Ruan, Fengkai
AU  - Ruan F
AD  - State Key Laboratory of Cellular Stress Biology, School of Life Sciences, The 
      Fifth Hospital of Xiamen, Xiang'an Branch of the First Affiliated Hospital, 
      Xiamen University, Xiamen, Fujian, 361102, China.
FAU - Liu, Changqian
AU  - Liu C
AD  - State Key Laboratory of Cellular Stress Biology, School of Life Sciences, The 
      Fifth Hospital of Xiamen, Xiang'an Branch of the First Affiliated Hospital, 
      Xiamen University, Xiamen, Fujian, 361102, China.
FAU - Hu, Weiping
AU  - Hu W
AD  - State Key Laboratory of Cellular Stress Biology, School of Life Sciences, The 
      Fifth Hospital of Xiamen, Xiang'an Branch of the First Affiliated Hospital, 
      Xiamen University, Xiamen, Fujian, 361102, China.
FAU - Ruan, Jinpeng
AU  - Ruan J
AD  - State Key Laboratory of Cellular Stress Biology, School of Life Sciences, The 
      Fifth Hospital of Xiamen, Xiang'an Branch of the First Affiliated Hospital, 
      Xiamen University, Xiamen, Fujian, 361102, China.
FAU - Ding, Xiaoyan
AU  - Ding X
AD  - State Key Laboratory of Cellular Stress Biology, School of Life Sciences, The 
      Fifth Hospital of Xiamen, Xiang'an Branch of the First Affiliated Hospital, 
      Xiamen University, Xiamen, Fujian, 361102, China.
FAU - Zhang, Lu
AU  - Zhang L
AD  - State Key Laboratory of Cellular Stress Biology, School of Life Sciences, The 
      Fifth Hospital of Xiamen, Xiang'an Branch of the First Affiliated Hospital, 
      Xiamen University, Xiamen, Fujian, 361102, China.
FAU - Yang, Chunyan
AU  - Yang C
AD  - State Key Laboratory of Cellular Stress Biology, School of Life Sciences, The 
      Fifth Hospital of Xiamen, Xiang'an Branch of the First Affiliated Hospital, 
      Xiamen University, Xiamen, Fujian, 361102, China.
FAU - Zuo, Zhenghong
AU  - Zuo Z
AD  - State Key Laboratory of Cellular Stress Biology, School of Life Sciences, The 
      Fifth Hospital of Xiamen, Xiang'an Branch of the First Affiliated Hospital, 
      Xiamen University, Xiamen, Fujian, 361102, China.
FAU - He, Chengyong
AU  - He C
AD  - State Key Laboratory of Cellular Stress Biology, School of Life Sciences, The 
      Fifth Hospital of Xiamen, Xiang'an Branch of the First Affiliated Hospital, 
      Xiamen University, Xiamen, Fujian, 361102, China.
FAU - Huang, Jiyi
AU  - Huang J
AD  - State Key Laboratory of Cellular Stress Biology, School of Life Sciences, The 
      Fifth Hospital of Xiamen, Xiang'an Branch of the First Affiliated Hospital, 
      Xiamen University, Xiamen, Fujian, 361102, China. Electronic address: 
      hjy0602@163.com.
LA  - eng
PT  - Journal Article
DEP - 20220211
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 0 (Environmental Pollutants)
RN  - 268B43MJ25 (Uric Acid)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - *Environmental Pollutants/toxicity
MH  - *Hyperuricemia
MH  - Kidney
MH  - Male
MH  - Mice
MH  - *Polychlorinated Biphenyls/toxicity
MH  - Uric Acid
OTO - NOTNLM
OT  - ER stress
OT  - Fibrosis
OT  - Kidney injury
OT  - Mitochondrion
OT  - Polychlorinated biphenyls
OT  - Uric acid
EDAT- 2022/02/15 06:00
MHDA- 2022/03/23 06:00
CRDT- 2022/02/14 20:11
PHST- 2021/12/30 00:00 [received]
PHST- 2022/02/03 00:00 [revised]
PHST- 2022/02/08 00:00 [accepted]
PHST- 2022/02/15 06:00 [pubmed]
PHST- 2022/03/23 06:00 [medline]
PHST- 2022/02/14 20:11 [entrez]
AID - S0269-7491(22)00191-9 [pii]
AID - 10.1016/j.envpol.2022.118977 [doi]
PST - ppublish
SO  - Environ Pollut. 2022 May 15;301:118977. doi: 10.1016/j.envpol.2022.118977. Epub 
      2022 Feb 11.