PMID- 35159216
OWN - NLM
STAT- MEDLINE
DCOM- 20220408
LR  - 20220408
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 11
IP  - 3
DP  - 2022 Jan 25
TI  - New Insights into the Mechanisms of Chaperon-Mediated Autophagy and Implications 
      for Kidney Diseases.
LID - 10.3390/cells11030406 [doi]
LID - 406
AB  - Chaperone-mediated autophagy (CMA) is a separate type of lysosomal proteolysis, 
      characterized by its selectivity of substrate proteins and direct translocation 
      into lysosomes. Recent studies have declared the involvement of CMA in a variety 
      of physiologic and pathologic situations involving the kidney, and it has emerged 
      as a potential target for the treatment of kidney diseases. The role of CMA in 
      kidney diseases is context-dependent and appears reciprocally with 
      macroautophagy. Among the renal resident cells, the proximal tubule exhibits a 
      high basal level of CMA activity, and restoration of CMA alleviates the 
      aging-related tubular alternations. The level of CMA is up-regulated under 
      conditions of oxidative stress, such as in acute kidney injury, while it is 
      declined in chronic kidney disease and aging-related kidney diseases, leading to 
      the accumulation of oxidized substrates. Suppressed CMA leads to the kidney 
      hypertrophy in diabetes mellitus, and the increase of CMA contributes to the 
      progress and chemoresistance in renal cell carcinoma. With the progress on the 
      understanding of the cellular functions and uncovering the clinical scenario, the 
      application of targeting CMA in the treatment of kidney diseases is expected.
FAU - Yuan, Zhen
AU  - Yuan Z
AD  - Pathology Department, The School of Medicine, Nankai University, 94 Weijin Road, 
      Nankai District, Tianjin 300071, China.
FAU - Wang, Shuyuan
AU  - Wang S
AD  - Pathology Department, The School of Medicine, Nankai University, 94 Weijin Road, 
      Nankai District, Tianjin 300071, China.
FAU - Tan, Xiaoyue
AU  - Tan X
AUID- ORCID: 0000-0003-3394-9063
AD  - Pathology Department, The School of Medicine, Nankai University, 94 Weijin Road, 
      Nankai District, Tianjin 300071, China.
FAU - Wang, Dekun
AU  - Wang D
AD  - Pathology Department, The School of Medicine, Nankai University, 94 Weijin Road, 
      Nankai District, Tianjin 300071, China.
LA  - eng
GR  - 81872554 (X.T) and 82000708 (D.W)/National Natural Science Foundation of China/
GR  - 201910055106 (S.W. and Z.Y.)/National College Student Innovation and 
      Entrepreneurship Training Program of China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220125
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
SB  - IM
MH  - Autophagy/physiology
MH  - *Chaperone-Mediated Autophagy
MH  - Humans
MH  - *Kidney Diseases/metabolism
MH  - Lysosomes/metabolism
PMC - PMC8834181
OTO - NOTNLM
OT  - chaperon-mediated autophagy
OT  - heat shock-cognate 71 kDa protein
OT  - kidney diseases
OT  - lysosomal associated protein 2A
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/02/16 06:00
MHDA- 2022/04/09 06:00
PMCR- 2022/01/25
CRDT- 2022/02/15 01:04
PHST- 2021/12/24 00:00 [received]
PHST- 2022/01/14 00:00 [revised]
PHST- 2022/01/18 00:00 [accepted]
PHST- 2022/02/15 01:04 [entrez]
PHST- 2022/02/16 06:00 [pubmed]
PHST- 2022/04/09 06:00 [medline]
PHST- 2022/01/25 00:00 [pmc-release]
AID - cells11030406 [pii]
AID - cells-11-00406 [pii]
AID - 10.3390/cells11030406 [doi]
PST - epublish
SO  - Cells. 2022 Jan 25;11(3):406. doi: 10.3390/cells11030406.