PMID- 35159252
OWN - NLM
STAT- MEDLINE
DCOM- 20220408
LR  - 20220408
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 11
IP  - 3
DP  - 2022 Jan 27
TI  - Static Magnetic Fields Reduce Oxidative Stress to Improve Wound Healing and 
      Alleviate Diabetic Complications.
LID - 10.3390/cells11030443 [doi]
LID - 443
AB  - Although some studies have shown that some static magnetic fields (SMFs) can 
      promote wound healing in diabetic mice, it is not clear whether the other 
      diabetes complications, such as liver disease and diabetic nephropathy, can also 
      be alleviated. Here, we constructed two simple magnetic plates using neodymium 
      permanent magnets to examine the comprehensive effects of moderate SMFs on 
      genetically obese leptin receptor-deficient db/db diabetic mice. We found that 
      although the blood glucose was not obviously reduced by these two SMF settings, 
      both of the glycated serum protein (GSP) and malondialdehyde (MDA) levels were 
      significantly decreased (Cohen's d = 2.57-3.04). Moreover, the wound healing, 
      liver lipid accumulation, and renal defects were all significantly improved by 
      SMF treatment (Cohen's d = 0.91-2.05). Wound tissue examination showed obvious 
      nuclear factor erythroid 2-related factor 2 (NRF2) level decrease (Cohen's d = 
      2.49-5.40) and Ki-67 level increase (Cohen's d = 2.30-3.40), indicating decreased 
      oxidative stress and increased cell proliferation. In vitro cellular studies with 
      fibroblast NIH3T3 cells showed that SMFs could reduce high glucose-induced NRF2 
      nucleus translocation (Cohen's d = 0.87-1.15) and cellular reactive oxygen 
      species (ROS) elevation (Cohen's d = 0.92), indicating decreased oxidative 
      stress. Consequently, high glucose-induced impairments in cell vitality, 
      proliferation, and migration were all improved by SMF treatment. Therefore, our 
      results demonstrate that these simple SMF devices could effectively reduce 
      oxidative stress in diabetic mice and may provide a cost-effective physical 
      therapy strategy to alleviate multiple diabetic complications in the future.
FAU - Feng, Chuanlin
AU  - Feng C
AUID- ORCID: 0000-0002-8762-1242
AD  - Institutes of Physical Science and Information Technology, Anhui University, 
      Hefei 230039, China.
AD  - High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese 
      Academy of Sciences, Hefei 230031, China.
FAU - Yu, Biao
AU  - Yu B
AUID- ORCID: 0000-0003-4365-7726
AD  - High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese 
      Academy of Sciences, Hefei 230031, China.
AD  - Science Island Branch of Graduate School, University of Science and Technology of 
      China, Hefei 230026, China.
FAU - Song, Chao
AU  - Song C
AD  - High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese 
      Academy of Sciences, Hefei 230031, China.
AD  - Science Island Branch of Graduate School, University of Science and Technology of 
      China, Hefei 230026, China.
FAU - Wang, Junjun
AU  - Wang J
AD  - High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese 
      Academy of Sciences, Hefei 230031, China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese 
      Academy of Sciences, Hefei 230031, China.
FAU - Ji, Xinmiao
AU  - Ji X
AUID- ORCID: 0000-0002-2114-9985
AD  - High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese 
      Academy of Sciences, Hefei 230031, China.
FAU - Wang, Ying
AU  - Wang Y
AD  - High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese 
      Academy of Sciences, Hefei 230031, China.
AD  - Science Island Branch of Graduate School, University of Science and Technology of 
      China, Hefei 230026, China.
FAU - Fang, Yanwen
AU  - Fang Y
AD  - Heye Health Technology Co., Ltd., Huzhou 313300, China.
FAU - Liao, Zhongcai
AU  - Liao Z
AD  - Heye Health Technology Co., Ltd., Huzhou 313300, China.
FAU - Wei, Min
AU  - Wei M
AUID- ORCID: 0000-0002-2649-9271
AD  - Heye Health Technology Co., Ltd., Huzhou 313300, China.
FAU - Zhang, Xin
AU  - Zhang X
AUID- ORCID: 0000-0002-3499-2189
AD  - Institutes of Physical Science and Information Technology, Anhui University, 
      Hefei 230039, China.
AD  - High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese 
      Academy of Sciences, Hefei 230031, China.
AD  - Science Island Branch of Graduate School, University of Science and Technology of 
      China, Hefei 230026, China.
AD  - International Magnetobiology Frontier Research Center (iMFRC), Science Island, 
      Hefei 230031, China.
LA  - eng
GR  - 2021YFA1600100/National Key Research and Development Program of China/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220127
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 0 (Blood Glucose)
RN  - 0 (NF-E2-Related Factor 2)
SB  - IM
MH  - Animals
MH  - Blood Glucose
MH  - *Diabetes Complications/complications/therapy
MH  - *Diabetes Mellitus, Experimental/metabolism
MH  - Magnetic Fields
MH  - Mice
MH  - NF-E2-Related Factor 2/metabolism
MH  - NIH 3T3 Cells
MH  - Oxidative Stress
MH  - Wound Healing
PMC - PMC8834397
OTO - NOTNLM
OT  - NRF2
OT  - diabetic wound healing
OT  - oxidative stress
OT  - physical therapy
OT  - static magnetic fields
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2022/02/16 06:00
MHDA- 2022/04/09 06:00
PMCR- 2022/01/27
CRDT- 2022/02/15 01:04
PHST- 2021/12/08 00:00 [received]
PHST- 2022/01/22 00:00 [revised]
PHST- 2022/01/24 00:00 [accepted]
PHST- 2022/02/15 01:04 [entrez]
PHST- 2022/02/16 06:00 [pubmed]
PHST- 2022/04/09 06:00 [medline]
PHST- 2022/01/27 00:00 [pmc-release]
AID - cells11030443 [pii]
AID - cells-11-00443 [pii]
AID - 10.3390/cells11030443 [doi]
PST - epublish
SO  - Cells. 2022 Jan 27;11(3):443. doi: 10.3390/cells11030443.