PMID- 35159323
OWN - NLM
STAT- MEDLINE
DCOM- 20220408
LR  - 20220408
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 11
IP  - 3
DP  - 2022 Feb 2
TI  - Monocytes and Macrophages in Spondyloarthritis: Functional Roles and Effects of 
      Current Therapies.
LID - 10.3390/cells11030515 [doi]
LID - 515
AB  - Spondyloarthritis (SpA) is a family of chronic inflammatory diseases, being the 
      most prevalent ankylosing spondylitis (AS) and psoriatic arthritis (PsA). These 
      diseases share genetic, clinical and immunological features, such as the 
      implication of human leukocyte antigen (HLA) class I molecule 27 (HLA-B27), the 
      inflammation of peripheral, spine and sacroiliac joints and the presence of 
      extra-articular manifestations (psoriasis, anterior uveitis, enthesitis and 
      inflammatory bowel disease). Monocytes and macrophages are essential cells of the 
      innate immune system and are the first line of defence against external agents. 
      In rheumatic diseases including SpA, the frequency and phenotypic and functional 
      characteristics of both cell types are deregulated and are involved in the 
      pathogenesis of these diseases. In fact, monocytes and macrophages play key roles 
      in the inflammatory processes characteristics of SpA. The aim of this review is 
      analysing the characteristics and functional roles of monocytes and macrophages 
      in these diseases, as well as the impact of different current therapies on these 
      cell types.
FAU - Martinez-Ramos, Sara
AU  - Martinez-Ramos S
AD  - Rheumatology & Immuno-Mediated Diseases Research Group (IRIDIS), Galicia Sur 
      Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain.
AD  - Rheumatology Department, University Hospital Complex of Vigo, 36214 Vigo, Spain.
FAU - Rafael-Vidal, Carlos
AU  - Rafael-Vidal C
AUID- ORCID: 0000-0002-4451-9248
AD  - Rheumatology & Immuno-Mediated Diseases Research Group (IRIDIS), Galicia Sur 
      Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain.
AD  - Rheumatology Department, University Hospital Complex of Vigo, 36214 Vigo, Spain.
FAU - Pego-Reigosa, Jose M
AU  - Pego-Reigosa JM
AUID- ORCID: 0000-0003-3461-3537
AD  - Rheumatology & Immuno-Mediated Diseases Research Group (IRIDIS), Galicia Sur 
      Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain.
AD  - Rheumatology Department, University Hospital Complex of Vigo, 36214 Vigo, Spain.
FAU - Garcia, Samuel
AU  - Garcia S
AUID- ORCID: 0000-0002-5902-2699
AD  - Rheumatology & Immuno-Mediated Diseases Research Group (IRIDIS), Galicia Sur 
      Health Research Institute (IIS Galicia Sur), SERGAS-UVIGO, 36312 Vigo, Spain.
AD  - Rheumatology Department, University Hospital Complex of Vigo, 36214 Vigo, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220202
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - HLA-B27 Antigen/genetics
MH  - Humans
MH  - Macrophages/pathology
MH  - Monocytes/pathology
MH  - *Spondylarthritis/pathology/therapy
MH  - *Spondylitis, Ankylosing/pathology/therapy
PMC - PMC8834543
OTO - NOTNLM
OT  - current therapies
OT  - macrophages
OT  - monocytes
OT  - spondyloarthritis
COIS- The authors declare no conflict of interest.
EDAT- 2022/02/16 06:00
MHDA- 2022/04/09 06:00
PMCR- 2022/02/02
CRDT- 2022/02/15 01:05
PHST- 2021/12/30 00:00 [received]
PHST- 2022/01/27 00:00 [revised]
PHST- 2022/01/28 00:00 [accepted]
PHST- 2022/02/15 01:05 [entrez]
PHST- 2022/02/16 06:00 [pubmed]
PHST- 2022/04/09 06:00 [medline]
PHST- 2022/02/02 00:00 [pmc-release]
AID - cells11030515 [pii]
AID - cells-11-00515 [pii]
AID - 10.3390/cells11030515 [doi]
PST - epublish
SO  - Cells. 2022 Feb 2;11(3):515. doi: 10.3390/cells11030515.