PMID- 35159454
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220219
IS  - 2304-8158 (Print)
IS  - 2304-8158 (Electronic)
IS  - 2304-8158 (Linking)
VI  - 11
IP  - 3
DP  - 2022 Jan 23
TI  - Study of the Contents of Analogues of Aristolochic Acid in Houttuynia cordata by 
      Ultra-High Performance Liquid Chromatography Tandem Mass Spectrometry.
LID - 10.3390/foods11030302 [doi]
LID - 302
AB  - In this study, a new and simple method was established for the simultaneous 
      determination of analogues of aristolochic acids (aristolochic acid I, 
      aristolochic acid II, aristolactam I and aristolactam AII) in Houttuynia cordata 
      by ultra-high performance liquid chromatography-quadrupole/time-of-flight mass 
      spectrometry (UHPLC-Q/TOF-MS). The samples were ultrasonically extracted with 
      methanol, purified with HC-C18, and then separated on a C18 column (75 x 2.1 mm, 
      2.0 mum) at 35  degrees C. Under the optimized conditions, aristolochic acid I (AA-I), 
      aristolochic acid II (AA-II), aristolactam I (AL-I) and aristolactam AII (AL-AII) 
      all showed good linear regression (not less than 0.9987). The average recoveries 
      of the four analytes were within the range of 72.3-105.5%, with the relative 
      standard deviations (RSDs) being </=7.6%. The proposed method was then applied to 
      the determination of Houttuynia cordata samples collected from different regions 
      in China. The results showed that none of the three carcinogenic substances 
      (aristolochic acid I, aristolochic acid II and aristolactam I) were detected in 
      any of the 22 samples collected from 22 different regions of China, while 
      aristolactam AII, which has not been reported to have genotoxicity, was detected 
      in all samples. This study provides a valuable reference for the further safety 
      assessment of Houttuynia cordata.
FAU - Yu, Xuan
AU  - Yu X
AD  - College of Chemistry, Nanchang University, Nanchang 330047, China.
FAU - Gao, Yuan
AU  - Gao Y
AD  - College of Chemistry, Nanchang University, Nanchang 330047, China.
FAU - Xu, Ying
AU  - Xu Y
AD  - College of Chemistry, Nanchang University, Nanchang 330047, China.
FAU - Guo, Xian
AU  - Guo X
AD  - College of Chemistry, Nanchang University, Nanchang 330047, China.
FAU - Guo, Lan
AU  - Guo L
AD  - College of Chemistry, Nanchang University, Nanchang 330047, China.
AD  - Jiangxi Province Key Laboratory of Modern Analytical Science, Nanchang 
      University, Nanchang 330047, China.
FAU - Tan, Ting
AU  - Tan T
AUID- ORCID: 0000-0002-7533-4553
AD  - Jiangxi Province Key Laboratory of Modern Analytical Science, Nanchang 
      University, Nanchang 330047, China.
FAU - Liu, Fan
AU  - Liu F
AD  - Jiangxi Province Key Laboratory of Modern Analytical Science, Nanchang 
      University, Nanchang 330047, China.
FAU - Wan, Yiqun
AU  - Wan Y
AUID- ORCID: 0000-0001-9596-6163
AD  - College of Chemistry, Nanchang University, Nanchang 330047, China.
AD  - Jiangxi Province Key Laboratory of Modern Analytical Science, Nanchang 
      University, Nanchang 330047, China.
LA  - eng
GR  - 2019YFC1604904/National Key Research and Development Project/
GR  - 20192BCD40001/Science and Technology Innovation Platform Project of Jiangxi 
      Province/
GR  - SKLF-ZZA- 201912/Objective-oriented Project for the State Key Laboratory of Food 
      Science and Technology, China in Nanchang University/
PT  - Journal Article
DEP - 20220123
PL  - Switzerland
TA  - Foods
JT  - Foods (Basel, Switzerland)
JID - 101670569
PMC - PMC8834043
OTO - NOTNLM
OT  - Houttuynia cordata
OT  - UHPLC-Q/TOF-MS
OT  - aristolochic acid analogues
OT  - detection
COIS- All authors declare no conflict of interest.
EDAT- 2022/02/16 06:00
MHDA- 2022/02/16 06:01
PMCR- 2022/01/23
CRDT- 2022/02/15 01:05
PHST- 2022/01/05 00:00 [received]
PHST- 2022/01/16 00:00 [revised]
PHST- 2022/01/18 00:00 [accepted]
PHST- 2022/02/15 01:05 [entrez]
PHST- 2022/02/16 06:00 [pubmed]
PHST- 2022/02/16 06:01 [medline]
PHST- 2022/01/23 00:00 [pmc-release]
AID - foods11030302 [pii]
AID - foods-11-00302 [pii]
AID - 10.3390/foods11030302 [doi]
PST - epublish
SO  - Foods. 2022 Jan 23;11(3):302. doi: 10.3390/foods11030302.