PMID- 35160092
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220219
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 3
DP  - 2022 Jan 27
TI  - Real-World Use and Adverse Events of SARS-CoV-2 Vaccination in Greek Patients 
      with Inflammatory Bowel Disease.
LID - 10.3390/jcm11030641 [doi]
LID - 641
AB  - Since inflammatory bowel disease (IBD) patients were excluded from vaccine 
      authorization studies, limited knowledge exists regarding perceptions and 
      unfavorable effects of COVID-19 vaccination in this group. We aimed to 
      investigate the real-world use and adverse events (AEs) of COVID-19 vaccines in 
      Greek IBD patients. Fully vaccinated IBD patients followed in Greek centers were 
      invited to participate. All patients filled out an anonymous online survey 
      concerning the vaccination program, which included information regarding 
      demographics, clinical characteristics, treatment, vaccination perceptions and 
      potential AEs. Overall, 1007 IBD patients were included. Vaccine hesitancy was 
      reported by 49%. Total AEs to vaccination were reported by 81% after dose 1 (D1) 
      and 76% after dose 2 (D2), including isolated injection site reactions (36% and 
      24% respectively). Systemic AEs were more common after D2 (51%, D2 vs. 44%, D1, p 
      < 0.0001). Very few patients reported new onset abdominal symptoms (abdominal 
      pain 4% (D1), 6% (D2) and diarrhea 5% (D1), 7% (D2)). There were no serious AEs 
      leading to emergency room visit or hospitalization. In multivariate analysis, AEs 
      occurrence was positively associated with young age and female gender (p < 0.0005 
      for both doses), whereas inactive disease was negatively associated with AE in D1 
      (p = 0.044). SARS-CoV-2 vaccination in Greek IBD patients demonstrated a 
      favorable and reassuring safety profile.
FAU - Orfanoudaki, Eleni
AU  - Orfanoudaki E
AUID- ORCID: 0000-0002-5426-2757
AD  - Department of Gastroenterology, University Hospital of Heraklion, Medical School, 
      University of Crete, 71110 Heraklion, Greece.
FAU - Zacharopoulou, Eirini
AU  - Zacharopoulou E
AUID- ORCID: 0000-0001-8154-0444
AD  - Department of Gastroenterology, General Hospital of Nikaia Piraeus "Ag. 
      Panteleimon"-General Hospital Dytikis Attikis "Agia Varvara", 12351 Athens, 
      Greece.
FAU - Kitsou, Vassiliki
AU  - Kitsou V
AD  - Gastroenterology Unit, 3rd Academic Department of Internal Medicine, National and 
      Kapodistrian Univeristy of Athens, "Sotiria" General Hospital, 11527 Athens, 
      Greece.
FAU - Karmiris, Konstantinos
AU  - Karmiris K
AD  - Department of Gastroenterology, Venizelio General Hospital, 71409 Heraklion, 
      Greece.
FAU - Theodoropoulou, Angeliki
AU  - Theodoropoulou A
AD  - Department of Gastroenterology, Venizelio General Hospital, 71409 Heraklion, 
      Greece.
FAU - Mantzaris, Gerassimos J
AU  - Mantzaris GJ
AD  - Department of Gastroenterology, General Hospital of Athens, 
      Evaggelismos-Polykliniki, 10676 Athens, Greece.
FAU - Tzouvala, Maria
AU  - Tzouvala M
AD  - Department of Gastroenterology, General Hospital of Nikaia Piraeus "Ag. 
      Panteleimon"-General Hospital Dytikis Attikis "Agia Varvara", 12351 Athens, 
      Greece.
FAU - Michopoulos, Spyridon
AU  - Michopoulos S
AD  - Department of Gastroenterology, General Hospital of Athens "Alexandra", 11528 
      Athens, Greece.
FAU - Zampeli, Evanthia
AU  - Zampeli E
AD  - Department of Gastroenterology, General Hospital of Athens "Alexandra", 11528 
      Athens, Greece.
FAU - Michalopoulos, Georgios
AU  - Michalopoulos G
AD  - Department of Gastroenterology, General Hospital of Piraeus "Tzaneio", Piraeus, 
      18536 Athens, Greece.
FAU - Karatzas, Pantelis
AU  - Karatzas P
AD  - Department of Gastroenterology, National and Kapodistrian University of Athens, 
      General Hospital of Athens "Laiko", 11527 Athens, Greece.
FAU - Viazis, Nikos
AU  - Viazis N
AUID- ORCID: 0000-0002-0918-1587
AD  - Department of Gastroenterology, General Hospital of Athens, 
      Evaggelismos-Polykliniki, 10676 Athens, Greece.
FAU - Liatsos, Christos
AU  - Liatsos C
AUID- ORCID: 0000-0001-8025-0808
AD  - Gastroenterology Department, 401 General Army Hospital of Athens, 11525 Athens, 
      Greece.
FAU - Bamias, Giorgos
AU  - Bamias G
AD  - Gastroenterology Unit, 3rd Academic Department of Internal Medicine, National and 
      Kapodistrian Univeristy of Athens, "Sotiria" General Hospital, 11527 Athens, 
      Greece.
FAU - Koutroubakis, Ioannis E
AU  - Koutroubakis IE
AD  - Department of Gastroenterology, University Hospital of Heraklion, Medical School, 
      University of Crete, 71110 Heraklion, Greece.
FAU - On Behalf Of The Hellenic Group For The Study Of Ibd
AU  - On Behalf Of The Hellenic Group For The Study Of Ibd
LA  - eng
PT  - Journal Article
DEP - 20220127
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8836981
OTO - NOTNLM
OT  - COVID-19
OT  - Crohn's disease
OT  - ulcerative colitis
OT  - vaccine
COIS- The authors declare no conflict of interest.
EDAT- 2022/02/16 06:00
MHDA- 2022/02/16 06:01
PMCR- 2022/01/27
CRDT- 2022/02/15 01:07
PHST- 2021/11/07 00:00 [received]
PHST- 2022/01/12 00:00 [revised]
PHST- 2022/01/19 00:00 [accepted]
PHST- 2022/02/15 01:07 [entrez]
PHST- 2022/02/16 06:00 [pubmed]
PHST- 2022/02/16 06:01 [medline]
PHST- 2022/01/27 00:00 [pmc-release]
AID - jcm11030641 [pii]
AID - jcm-11-00641 [pii]
AID - 10.3390/jcm11030641 [doi]
PST - epublish
SO  - J Clin Med. 2022 Jan 27;11(3):641. doi: 10.3390/jcm11030641.