PMID- 35160769
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220219
IS  - 1996-1944 (Print)
IS  - 1996-1944 (Electronic)
IS  - 1996-1944 (Linking)
VI  - 15
IP  - 3
DP  - 2022 Jan 21
TI  - Effect of Hydroxyapatite Nanoparticles and Nitrogen Plasma Treatment on 
      Osteoblast Biological Behaviors of 3D-Printed HDPE Scaffold for Bone Tissue 
      Regeneration Applications.
LID - 10.3390/ma15030827 [doi]
LID - 827
AB  - The need for the repair of bone defects has been increasing due to various causes 
      of loss of skeletal tissue. High density polyethylenes (HDPE) have been used as 
      bone substitutes due to their excellent biocompatibility and mechanical strength. 
      In the present study, we investigated the preosteoblast cell proliferation and 
      differentiation on the adding nano-hydroxyapatite (n-HAp) particles into HDPE 
      scaffold and treating HDPE/n-HAp scaffolds with nitrogen (N(2)) plasma. The 
      three-dimensional (3D) HDPE/n-HAp scaffolds were prepared by fused modeling 
      deposition 3D printer. The HDPE/n-HAp was blended with 10 wt% of n-HAp particle. 
      The scaffold surface was reactive ion etched with nitrogen plasma to improve the 
      preosteoblast biological response in vitro. After N(2) plasma treatment, surfaces 
      characterizations were investigated using Fourier transform infrared 
      spectroscopy, scanning electron microscopy, and atomic force microscopy. The 
      proliferation and differentiation of preosteoblast (MC3T3-E1) cells were 
      evaluated by MTT assay and alkaline phosphatase (ALP) activity. The incorporation 
      of n-HAp particles and N(2) plasma surface treatment showed the improvement of 
      biological responses of MC3T3-E1 cells in the HDPE scaffolds.
FAU - Park, Hyunchul
AU  - Park H
AD  - Bitgoeul Dental Clinic 2F, Doklibro 8 Nam-gu, Gwangju 61660, Korea.
FAU - Ryu, Jaeyoung
AU  - Ryu J
AUID- ORCID: 0000-0002-2940-5875
AD  - Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam 
      National University, Gwangju 61186, Korea.
FAU - Jung, Seunggon
AU  - Jung S
AD  - Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam 
      National University, Gwangju 61186, Korea.
FAU - Park, Hongju
AU  - Park H
AD  - Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam 
      National University, Gwangju 61186, Korea.
FAU - Oh, Heekyun
AU  - Oh H
AD  - Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam 
      National University, Gwangju 61186, Korea.
FAU - Kook, Minsuk
AU  - Kook M
AUID- ORCID: 0000-0002-8053-8534
AD  - Department of Oral and Maxillofacial Surgery, School of Dentistry, Chonnam 
      National University, Gwangju 61186, Korea.
LA  - eng
PT  - Journal Article
DEP - 20220121
PL  - Switzerland
TA  - Materials (Basel)
JT  - Materials (Basel, Switzerland)
JID - 101555929
PMC - PMC8836530
OTO - NOTNLM
OT  - 3D printing
OT  - 3D scaffold
OT  - bone substitute
OT  - high density polyethylene
OT  - plasma surface treatment
COIS- The authors declare no conflict of interest.
EDAT- 2022/02/16 06:00
MHDA- 2022/02/16 06:01
PMCR- 2022/01/21
CRDT- 2022/02/15 01:09
PHST- 2021/12/21 00:00 [received]
PHST- 2022/01/07 00:00 [revised]
PHST- 2022/01/19 00:00 [accepted]
PHST- 2022/02/15 01:09 [entrez]
PHST- 2022/02/16 06:00 [pubmed]
PHST- 2022/02/16 06:01 [medline]
PHST- 2022/01/21 00:00 [pmc-release]
AID - ma15030827 [pii]
AID - materials-15-00827 [pii]
AID - 10.3390/ma15030827 [doi]
PST - epublish
SO  - Materials (Basel). 2022 Jan 21;15(3):827. doi: 10.3390/ma15030827.