PMID- 35162777
OWN - NLM
STAT- MEDLINE
DCOM- 20220228
LR  - 20220228
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 19
IP  - 3
DP  - 2022 Feb 3
TI  - Traditional East Asian Herbal Medicine for Post-Stroke Insomnia: A Systematic 
      Review and Meta-Analysis of Randomized Controlled Trials.
LID - 10.3390/ijerph19031754 [doi]
LID - 1754
AB  - Post-stroke insomnia (PSI) is a highly prevalent complication after stroke. 
      Current evidence of psychotropic drug use for PSI management is scarce and 
      indicates harmful adverse events (AEs). Traditional East Asian herbal medicine is 
      a widely used traditional remedy for insomnia. However, so far, no study has 
      systematically reviewed the efficacy and safety of traditional east asian herbal 
      medicine (HM) for PSI. Therefore, we perform meta-analysis to evaluate the 
      effectiveness and safety of HM for PSI. After a comprehensive electronic search 
      of 15 databases, we review the randomized controlled trials (RCTs) of HM use as 
      monotherapy for PSI. Our outcomes were the Pittsburgh sleep quality index and 
      total effective rate. In total, 24 RCTs were conducted with 1942 participants. HM 
      showed statistically significant benefits in sleep quality. It also appeared to 
      be safer than psychotropic drugs in terms of AEs, except when the treatment 
      period was two weeks. The methods used for RCTs were poor, and the quality of 
      evidence assessed was graded "low" or "moderate." The findings of this review 
      indicate that the use of HM as a monotherapy may have potential benefits in PSI 
      treatment when administered as an alternative to conventional medications. 
      However, considering the methodological quality of the included RCTs, we were 
      uncertain of the clinical evidence. Further, well-designed RCTs are required to 
      confirm these findings.
FAU - Kim, Sang-Ho
AU  - Kim SH
AUID- ORCID: 0000-0001-7905-1772
AD  - Department of Neuropsychiatry of Korean Medicine, Pohang Korean Medicine 
      Hospital, Daegu Haany University, 411 Saecheonnyeon-daero, Pohang-si 37685, 
      Korea.
FAU - Lim, Jung-Hwa
AU  - Lim JH
AUID- ORCID: 0000-0003-2687-6433
AD  - Department of Neuropsychiatry, School of Korean Medicine, Pusan National 
      University, 49 Busandaehak-ro, Mulgeum-eup, Yangsan-si 50612, Korea.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PT  - Systematic Review
DEP - 20220203
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
RN  - 0 (Drugs, Chinese Herbal)
SB  - IM
MH  - Data Management
MH  - *Drugs, Chinese Herbal/therapeutic use
MH  - Herbal Medicine/methods
MH  - Humans
MH  - Randomized Controlled Trials as Topic
MH  - *Sleep Initiation and Maintenance Disorders/complications/etiology
MH  - *Stroke/complications/drug therapy
PMC - PMC8834856
OTO - NOTNLM
OT  - herbal medicine
OT  - insomnia
OT  - meta-analysis
OT  - stroke
OT  - systematic review
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2022/02/16 06:00
MHDA- 2022/03/01 06:00
PMCR- 2022/02/03
CRDT- 2022/02/15 01:15
PHST- 2021/12/13 00:00 [received]
PHST- 2022/01/25 00:00 [revised]
PHST- 2022/01/31 00:00 [accepted]
PHST- 2022/02/15 01:15 [entrez]
PHST- 2022/02/16 06:00 [pubmed]
PHST- 2022/03/01 06:00 [medline]
PHST- 2022/02/03 00:00 [pmc-release]
AID - ijerph19031754 [pii]
AID - ijerph-19-01754 [pii]
AID - 10.3390/ijerph19031754 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2022 Feb 3;19(3):1754. doi: 
      10.3390/ijerph19031754.