PMID- 35163403
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20220314
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 23
IP  - 3
DP  - 2022 Jan 27
TI  - Role of the Interaction of Tumor Necrosis Factor-alpha and Tumor Necrosis Factor 
      Receptors 1 and 2 in Bone-Related Cells.
LID - 10.3390/ijms23031481 [doi]
LID - 1481
AB  - Tumor necrosis factor-alpha (TNF-alpha) is a pleiotropic cytokine expressed by 
      macrophages, monocytes, and T cells, and its expression is triggered by the 
      immune system in response to pathogens and their products, such as endotoxins. 
      TNF-alpha plays an important role in host defense by inducing inflammatory reactions 
      such as phagocytes and cytocidal systems activation. TNF-alpha also plays an 
      important role in bone metabolism and is associated with inflammatory bone 
      diseases. TNF-alpha binds to two cell surface receptors, the 55kDa TNF receptor-1 
      (TNFR1) and the 75kDa TNF receptor-2 (TNFR2). Bone is in a constant state of 
      turnover; it is continuously degraded and built via the process of bone 
      remodeling, which results from the regulated balance between bone-resorbing 
      osteoclasts, bone-forming osteoblasts, and the mechanosensory cell type 
      osteocytes. Precise interactions between these cells maintain skeletal 
      homeostasis. Studies have shown that TNF-alpha affects bone-related cells via TNFRs. 
      Signaling through either receptor results in different outcomes in different cell 
      types as well as in the same cell type. This review summarizes and discusses 
      current research on the TNF-alpha and TNFR interaction and its role in bone-related 
      cells.
FAU - Kitaura, Hideki
AU  - Kitaura H
AUID- ORCID: 0000-0003-3249-4247
AD  - Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate 
      School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
FAU - Marahleh, Aseel
AU  - Marahleh A
AD  - Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate 
      School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
FAU - Ohori, Fumitoshi
AU  - Ohori F
AD  - Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate 
      School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
FAU - Noguchi, Takahiro
AU  - Noguchi T
AD  - Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate 
      School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
FAU - Nara, Yasuhiko
AU  - Nara Y
AD  - Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate 
      School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
FAU - Pramusita, Adya
AU  - Pramusita A
AD  - Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate 
      School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
FAU - Kinjo, Ria
AU  - Kinjo R
AD  - Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate 
      School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
FAU - Ma, Jinghan
AU  - Ma J
AD  - Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate 
      School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
FAU - Kanou, Kayoko
AU  - Kanou K
AD  - Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate 
      School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
FAU - Mizoguchi, Itaru
AU  - Mizoguchi I
AD  - Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate 
      School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan.
LA  - eng
GR  - 19K10397/Japan Society for the Promotion of Science/
PT  - Journal Article
PT  - Review
DEP - 20220127
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (TNFRSF1A protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - *Bone Remodeling
MH  - Humans
MH  - Osteoblasts/*metabolism
MH  - Osteocytes/*metabolism
MH  - Receptors, Tumor Necrosis Factor, Type I/*metabolism
MH  - Receptors, Tumor Necrosis Factor, Type II/*metabolism
MH  - *Signal Transduction
MH  - Tumor Necrosis Factor-alpha/*metabolism
PMC - PMC8835906
OTO - NOTNLM
OT  - TNF receptor-1
OT  - TNF receptor-2
OT  - TNF-alpha
OT  - osteoblast
OT  - osteoclast
OT  - osteocyte
COIS- The authors declare no conflict of interest.
EDAT- 2022/02/16 06:00
MHDA- 2022/03/15 06:00
PMCR- 2022/01/27
CRDT- 2022/02/15 01:17
PHST- 2021/12/29 00:00 [received]
PHST- 2022/01/24 00:00 [revised]
PHST- 2022/01/26 00:00 [accepted]
PHST- 2022/02/15 01:17 [entrez]
PHST- 2022/02/16 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2022/01/27 00:00 [pmc-release]
AID - ijms23031481 [pii]
AID - ijms-23-01481 [pii]
AID - 10.3390/ijms23031481 [doi]
PST - epublish
SO  - Int J Mol Sci. 2022 Jan 27;23(3):1481. doi: 10.3390/ijms23031481.