PMID- 35164605
OWN - NLM
STAT- MEDLINE
DCOM- 20220408
LR  - 20220608
IS  - 1477-0377 (Electronic)
IS  - 1358-863X (Linking)
VI  - 27
IP  - 2
DP  - 2022 Apr
TI  - Minimal clinically important differences in daily physical activity outcomes 
      following supervised and home-based exercise in peripheral artery disease.
PG  - 142-149
LID - 10.1177/1358863X211072913 [doi]
AB  - Introduction: We estimated minimal clinically important differences (MCID) for 
      small, moderate, and large changes in daily step counts and time spent in 
      moderate-to-vigorous physical activity (MVPA) following both supervised and 
      home-based exercise programs in symptomatic patients with peripheral artery 
      disease (PAD). Methods: Patients were randomized to either 12 weeks of a 
      supervised exercise program (n = 60), a home-based exercise program (n = 60), or 
      an attention-control group (n = 60). Results: Using the anchor-based method to 
      determine MCID, the MCID value for a large change in health-related quality of 
      life (HRQoL) was an increase of 1211 total daily steps and an increase in 11 
      minutes in the time spent in MVPA following 12 weeks of exercise intervention. 
      Using the distribution-based method, the MCID values for small, moderate, and 
      large changes in total daily steps in the home-based exercise group were 558, 
      1396, and 2233 steps/d, respectively, and the corresponding changes in the time 
      spent in MVPA were 6, 15, and 23 minutes. Similar distribution-based MCID scores 
      were noted for the supervised exercise group. Conclusion: Following 3 months of 
      home-based and supervised exercise programs for patients with PAD and 
      claudication, increases of 11 minutes in time spent in MVPA and 1211 total daily 
      steps were associated with large anchor-based MCID increases in HRQoL. The 
      clinical implication is that patients with PAD and claudication should be 
      encouraged to increase daily steps, particularly by walking an additional 11 
      minutes each day in MVPA, which is associated with a large meaningful increase in 
      HRQoL.
FAU - Gardner, Andrew W
AU  - Gardner AW
AUID- ORCID: 0000-0001-7721-5438
AD  - Department of Physical Medicine and Rehabilitation, Penn State College of 
      Medicine, Hershey, PA, USA.
FAU - Montgomery, Polly S
AU  - Montgomery PS
AD  - Department of Physical Medicine and Rehabilitation, Penn State College of 
      Medicine, Hershey, PA, USA.
FAU - Wang, Ming
AU  - Wang M
AD  - Department of Public Health Sciences, Penn State College of Medicine, Hershey, 
      PA, USA.
FAU - Shen, Biyi
AU  - Shen B
AD  - Department of Public Health Sciences, Penn State College of Medicine, Hershey, 
      PA, USA.
LA  - eng
GR  - R01 AG024296/AG/NIA NIH HHS/United States
GR  - M01 RR014467/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
DEP - 20220215
PL  - England
TA  - Vasc Med
JT  - Vascular medicine (London, England)
JID - 9610930
SB  - IM
MH  - Exercise
MH  - Exercise Therapy
MH  - Humans
MH  - Intermittent Claudication/diagnosis/therapy
MH  - *Minimal Clinically Important Difference
MH  - *Peripheral Arterial Disease/diagnosis/therapy
MH  - Quality of Life
MH  - Walking
OTO - NOTNLM
OT  - claudication
OT  - peripheral artery disease (PAD)
OT  - physical activity
OT  - quality of life
OT  - walking
EDAT- 2022/02/16 06:00
MHDA- 2022/04/09 06:00
CRDT- 2022/02/15 05:30
PHST- 2022/02/16 06:00 [pubmed]
PHST- 2022/04/09 06:00 [medline]
PHST- 2022/02/15 05:30 [entrez]
AID - 10.1177/1358863X211072913 [doi]
PST - ppublish
SO  - Vasc Med. 2022 Apr;27(2):142-149. doi: 10.1177/1358863X211072913. Epub 2022 Feb 
      15.