PMID- 35164976
OWN - NLM
STAT- MEDLINE
DCOM- 20220419
LR  - 20220508
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 113
IP  - 1
DP  - 2022 May 1
TI  - Survival and Larynx Preservation in Early Glottic Cancer: A Randomized Trial 
      Comparing Laser Surgery and Radiation Therapy.
PG  - 96-100
LID - S0360-3016(22)00020-7 [pii]
LID - 10.1016/j.ijrobp.2022.01.010 [doi]
AB  - PURPOSE: The prognosis of glottic T1a laryngeal squamous cell carcinoma (LSCC) is 
      excellent with both transoral laser surgery (TLS) and radiation therapy (RT). Our 
      aim was to compare TLS and RT treatment results in a randomized study. METHODS 
      AND MATERIALS: Of 56 male patients with glottic T1a LSCC, 31 were randomized for 
      TLS and 25 for RT. Survival and larynx preservation data were collected from 
      medical records. RESULTS: Five-year overall survival (OS) was 87%, 
      disease-specific survival (DSS) was 97%, and recurrence-free survival (RFS) was 
      81% in patients treated with TLS. Five-year OS was 92%, DSS was 100%, and RFS was 
      88% in patients treated with RT. The primary treatment method was not associated 
      with OS, RFS, or DSS in a log-rank test. The larynx preservation rate was similar 
      in both groups (TLS, 97%; RT, 92%; P = .575). CONCLUSIONS: In a prospective 
      randomized setting oncological outcomes of both treatment modalities (TLS or RT) 
      for T1a LSCC were similar.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Pakkanen, Pihla
AU  - Pakkanen P
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki 
      and Helsinki University Hospital, Helsinki, Finland. Electronic address: 
      pihla.pakkanen@helsinki.fi.
FAU - Irjala, Heikki
AU  - Irjala H
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, University of Turku 
      and Turku University Hospital, Turku, Finland.
FAU - Ilmarinen, Taru
AU  - Ilmarinen T
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki 
      and Helsinki University Hospital, Helsinki, Finland.
FAU - Halme, Elina
AU  - Halme E
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, University of Tampere 
      and Tampere University Hospital, Tampere, Finland.
FAU - Lindholm, Paula
AU  - Lindholm P
AD  - Department of Oncology, University of Turku and Turku University Hospital, Turku, 
      Finland.
FAU - Makitie, Antti
AU  - Makitie A
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki 
      and Helsinki University Hospital, Helsinki, Finland; Division of Ear, Nose and 
      Throat Diseases, Department of Clinical Sciences, Intervention and Technology, 
      Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; 
      Research Program in Systems Oncology, Faculty of Medicine, University of 
      Helsinki, Helsinki, Finland.
FAU - Wigren, Tuija
AU  - Wigren T
AD  - Department of Oncology, Tampere University Hospital and University of Tampere, 
      Tampere, Finland.
FAU - Aaltonen, Leena-Maija
AU  - Aaltonen LM
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki 
      and Helsinki University Hospital, Helsinki, Finland.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20220211
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
MH  - Female
MH  - Glottis/pathology/surgery
MH  - *Head and Neck Neoplasms/pathology
MH  - Humans
MH  - *Laryngeal Neoplasms/pathology/radiotherapy/surgery
MH  - *Laser Therapy/methods
MH  - Male
MH  - Neoplasm Staging
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck/pathology
MH  - Survival Rate
MH  - *Tongue Neoplasms/pathology
MH  - Treatment Outcome
EDAT- 2022/02/16 06:00
MHDA- 2022/04/20 06:00
CRDT- 2022/02/15 05:33
PHST- 2021/11/01 00:00 [received]
PHST- 2021/12/19 00:00 [revised]
PHST- 2022/01/09 00:00 [accepted]
PHST- 2022/02/16 06:00 [pubmed]
PHST- 2022/04/20 06:00 [medline]
PHST- 2022/02/15 05:33 [entrez]
AID - S0360-3016(22)00020-7 [pii]
AID - 10.1016/j.ijrobp.2022.01.010 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2022 May 1;113(1):96-100. doi: 
      10.1016/j.ijrobp.2022.01.010. Epub 2022 Feb 11.