PMID- 35165331
OWN - NLM
STAT- MEDLINE
DCOM- 20220311
LR  - 20220311
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Feb 14
TI  - Beneficial effects of voluntary wheel running on activity rhythms, metabolic 
      state, and affect in a diurnal model of circadian disruption.
PG  - 2434
LID - 10.1038/s41598-022-06408-z [doi]
LID - 2434
AB  - Emerging evidence suggests that disruption of circadian rhythmicity contributes 
      to development of comorbid depression, cardiovascular diseases (CVD), and type 2 
      diabetes mellitus (T2DM). Physical exercise synchronizes the circadian system and 
      has ameliorating effects on the depression- and anxiety-like phenotype induced by 
      circadian disruption in mice and sand rats. We explored the beneficial effects of 
      voluntary wheel running on daily rhythms, and the development of depression, 
      T2DM, and CVD in a diurnal animal model, the fat sand rat (Psammomys obesus). 
      Voluntary exercise strengthened general activity rhythms, improved memory and 
      lowered anxiety- and depressive-like behaviors, enhanced oral glucose tolerance, 
      and decreased plasma insulin levels and liver weight. Animals with access to a 
      running wheel had larger heart weight and heart/body weight ratio, and thicker 
      left ventricular wall. Our results demonstrate that exercising ameliorates 
      pathological-like daily rhythms in activity and blood glucose levels, glucose 
      tolerance and depressive- and anxiety-like behaviors in the sand rat model, 
      supporting the important role of physical activity in modulating the "circadian 
      syndrome" and circadian rhythm-related diseases. We suggest that the utilization 
      of a diurnal rodent animal model may offer an effective way to further explore 
      metabolic, cardiovascular, and affective-like behavioral changes related to 
      chronodisruption and their underlying mechanisms.
CI  - (c) 2022. The Author(s).
FAU - Bilu, Carmel
AU  - Bilu C
AD  - School of Zoology, Tel Aviv University, 69978, Tel Aviv, Ramat Aviv, Israel. 
      Carmel.bilu@gmail.com.
FAU - Einat, Haim
AU  - Einat H
AD  - School of Behavioral Sciences, Tel Aviv-Yaffo Academic College, Tel Aviv, Israel.
FAU - Zimmet, Paul
AU  - Zimmet P
AD  - Department of Medicine, Monash University, Melbourne, VIC, Australia.
FAU - Vishnevskia-Dai, Vicktoria
AU  - Vishnevskia-Dai V
AD  - Ocular Oncology and Autoimmune Service, The Goldschleger Eye Institute, The Chaim 
      Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel Aviv 
      University, Tel Aviv, Israel.
FAU - Schwartz, William J
AU  - Schwartz WJ
AD  - Department of Neurology, Dell Medical School, The University of Texas at Austin, 
      Austin, TX, USA.
AD  - Department of Integrative Biology, College of Natural Sciences, The University of 
      Texas at Austin, Austin, TX, USA.
FAU - Kronfeld-Schor, Noga
AU  - Kronfeld-Schor N
AD  - School of Zoology, Tel Aviv University, 69978, Tel Aviv, Ramat Aviv, Israel.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220214
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
SB  - IM
MH  - Animals
MH  - Anxiety/complications/physiopathology/therapy
MH  - Blood Glucose/analysis
MH  - Cardiovascular Diseases/*complications/physiopathology/*therapy
MH  - Chronobiology Disorders/*complications/physiopathology/*therapy
MH  - *Circadian Rhythm
MH  - Depression/*complications/physiopathology/*therapy
MH  - Diabetes Mellitus, Type 2/blood/*complications/physiopathology/*therapy
MH  - Disease Models, Animal
MH  - Exercise Therapy/*methods
MH  - Gerbillinae
MH  - Glucose Tolerance Test
MH  - Insulin/blood
MH  - Locomotion
MH  - Male
MH  - Physical Conditioning, Animal/*methods
MH  - Rats
MH  - Suprachiasmatic Nucleus/physiopathology
MH  - Treatment Outcome
PMC - PMC8844006
COIS- The authors declare no competing interests.
EDAT- 2022/02/16 06:00
MHDA- 2022/03/12 06:00
PMCR- 2022/02/14
CRDT- 2022/02/15 05:35
PHST- 2021/11/23 00:00 [received]
PHST- 2022/01/19 00:00 [accepted]
PHST- 2022/02/15 05:35 [entrez]
PHST- 2022/02/16 06:00 [pubmed]
PHST- 2022/03/12 06:00 [medline]
PHST- 2022/02/14 00:00 [pmc-release]
AID - 10.1038/s41598-022-06408-z [pii]
AID - 6408 [pii]
AID - 10.1038/s41598-022-06408-z [doi]
PST - epublish
SO  - Sci Rep. 2022 Feb 14;12(1):2434. doi: 10.1038/s41598-022-06408-z.