PMID- 35165954
OWN - NLM
STAT- MEDLINE
DCOM- 20220419
LR  - 20220719
IS  - 1365-2826 (Electronic)
IS  - 0953-8194 (Print)
IS  - 0953-8194 (Linking)
VI  - 34
IP  - 3
DP  - 2022 Mar
TI  - ENETS standardized (synoptic) reporting for neuroendocrine tumour pathology.
PG  - e13100
LID - 10.1111/jne.13100 [doi]
LID - e13100
AB  - In recent years the WHO classification of neuroendocrine neoplasms (NEN) has 
      evolved. Nomenclature as well as thresholds for grading have changed leading to 
      potential confusion and lack of comparability of tumour reports. Therefore, the 
      European Neuroendocrine Tumour Society (ENETS) has set-up an interdisciplinary 
      working group to develop templates for a pathology data set for standardised 
      reporting of NEN. Experts of various disciplines, members of the ENETS Advisory 
      Board, formed a taskforce that discussed and decided on the structure, content 
      and the number of templates needed for reporting the most common NEN. The 
      selection of the required items was based on the WHO classification of digestive 
      system tumours, the WHO classification of tumours of the lung and mediastinum and 
      on "ENETS standard of care" reports. The final proposal of the working group was 
      approved by the ENETS Advisory Board. Templates for synoptic reporting were 
      created for the seven most common NEN primary sites, that is, stomach, duodenum, 
      jejunum-ileum, appendix, colon-rectum, pancreas, lung and mediastinum. In 
      addition, a general template for reporting biopsies was designed. The templates 
      allow the recording of the essential items on differentiation, proliferation 
      (Ki-67 and mitosis), neuroendocrine features (positivity for chromogranin A and 
      synaptophysin) and stage as well as several optional markers especially helpful 
      for the distinction of neuroendocrine tumours (NET) from neuroendocrine 
      carcinomas (NEC). In summary, this paper presents the content and development of 
      synoptic reports for most sites of NEN by a multidisciplinary team of 
      international experts in the field, which could help to improve unambiguous 
      reporting of NEN.
CI  - (c) 2022 The Authors. Journal of Neuroendocrinology published by John Wiley & Sons 
      Ltd on behalf of British Society for Neuroendocrinology.
FAU - van Velthuysen, Marie-Louise F
AU  - van Velthuysen MF
AUID- ORCID: 0000-0003-0435-9494
AD  - Department Pathology, Erasmus MC, Rotterdam, The Netherlands.
FAU - Couvelard, Anne
AU  - Couvelard A
AUID- ORCID: 0000-0002-6316-1210
AD  - Service de Pathologie, Hopital Bichat AP-HP et Universite de Paris, Paris, 
      France.
FAU - Rindi, Guido
AU  - Rindi G
AUID- ORCID: 0000-0003-2996-4404
AD  - Section of Anatomic Pathology, Department of Life Sciences and Public Health, 
      Universita Cattolica del Sacro Cuore, Roma, Italia.
AD  - Unit of Anatomic Pathology, Department of Woman and Child Health and Public 
      Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.
AD  - Roma European Neuroendocrine Tumor Society (ENETS) Center of Excellence, Roma, 
      Italia.
FAU - Fazio, Nicola
AU  - Fazio N
AUID- ORCID: 0000-0001-6869-0704
AD  - Division of gastrointestinal medical oncology and neuroendocrine tumors, European 
      Institute of Oncology (IEO), IRCCS, Milan, Italy.
FAU - Horsch, Dieter
AU  - Horsch D
AD  - CA Gastroenterologie, Zentralklinik Bad Berka GmbH, Bad Berka, Germany.
FAU - Nieveen van Dijkum, Els J
AU  - Nieveen van Dijkum EJ
AUID- ORCID: 0000-0002-3029-6071
AD  - Department of Surgery, Cancer Centre Amsterdam, Amsterdam UMC, University of 
      Amsterdam, Amsterdam, The Netherlands.
FAU - Kloppel, Gunter
AU  - Kloppel G
AUID- ORCID: 0000-0002-6688-086X
AD  - Department of Pathology, Consultation Center for Pancreatic and Endocrine Tumors, 
      TU Munich, Munich, Germany.
FAU - Perren, Aurel
AU  - Perren A
AUID- ORCID: 0000-0002-6819-6092
AD  - Institute of Pathology, University of Bern, Bern, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20220214
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
SB  - IM
MH  - Humans
MH  - *Neuroendocrine Tumors/pathology
MH  - Neurosecretory Systems
PMC - PMC9285411
OTO - NOTNLM
OT  - NEC
OT  - NET
OT  - neuro endocrine neoplasm
OT  - pathology report
OT  - synoptic report
COIS- Marie-Louise van Velthuysen, Anne Couvelard, Els J. Nieveen van Dijkum, Gunter 
      Kloppel and Aurel Perrenhave no conflicts of interest. Guido Rindi has received 
      speakers fees from AAA and is consultant for Bracco. Nicola Fazio has received 
      speakers fees from AAA, Hutchinson MediPharma, Merck and Novartis. Dieter Horsch 
      has received personalfees and grants from Lexicon Pharmaceuticals, Inc., Ipsen 
      Pharmaceuticals, Inc., Novartis Pharmaceuticals, Inc., and Pfizer 
      Pharmaceuticals, Inc., and advisory board honoraria from Advanz Pharma USA.
EDAT- 2022/02/16 06:00
MHDA- 2022/04/20 06:00
PMCR- 2022/07/15
CRDT- 2022/02/15 05:39
PHST- 2022/01/08 00:00 [revised]
PHST- 2021/09/09 00:00 [received]
PHST- 2022/01/18 00:00 [accepted]
PHST- 2022/02/16 06:00 [pubmed]
PHST- 2022/04/20 06:00 [medline]
PHST- 2022/02/15 05:39 [entrez]
PHST- 2022/07/15 00:00 [pmc-release]
AID - JNE13100 [pii]
AID - 10.1111/jne.13100 [doi]
PST - ppublish
SO  - J Neuroendocrinol. 2022 Mar;34(3):e13100. doi: 10.1111/jne.13100. Epub 2022 Feb 
      14.