PMID- 35166416
OWN - NLM
STAT- MEDLINE
DCOM- 20220503
LR  - 20220716
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Print)
IS  - 1065-9471 (Linking)
VI  - 43
IP  - 8
DP  - 2022 Jun 1
TI  - Disrupted topological organization of resting-state functional brain networks in 
      cerebral small vessel disease.
PG  - 2607-2620
LID - 10.1002/hbm.25808 [doi]
AB  - We aimed to investigate alterations in functional brain networks and assess the 
      relationship between functional impairment and topological network changes in 
      cerebral small vessel disease (CSVD) patients with and without cerebral 
      microbleeds (CMBs). We constructed individual whole-brain, region of interest 
      (ROI) level functional connectivity (FC) networks for 24 CSVD patients with CMBs 
      (CSVD-c), 42 CSVD patients without CMBs (CSVD-n), and 36 healthy controls (HCs). 
      Then, we used graph theory analysis to investigate the global and nodal 
      topological disruptions between groups and relate network topological alterations 
      to clinical parameters. We found that both the CSVD and control groups showed 
      efficient small-world organization in FC networks. However, compared to CSVD-n 
      patients and controls, CSVD-c patients exhibited a significantly decreased 
      clustering coefficient, global efficiency, and local efficiency and an increased 
      shortest path length, indicating a disrupted balance between local specialization 
      and global integration in FC networks. Although both the CSVD and control groups 
      showed highly similar hub distributions, the CSVD-c group exhibited significantly 
      altered nodal betweenness centrality (BC), mainly distributed in the default mode 
      network (DMN), attention, and visual functional areas. There were almost no 
      global or regional alterations between CSVD-n patients and controls. Furthermore, 
      the altered nodal BC of the right anterior/posterior cingulate gyrus and left 
      cuneus were significantly correlated with cognitive parameters in CSVD patients. 
      These results suggest that CSVD patients with and without CMBs had segregated 
      disruptions in the topological organization of the intrinsic functional brain 
      network. This study advances our current understanding of the pathophysiological 
      mechanisms underlying CSVD.
CI  - (c) 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
FAU - Xin, Haotian
AU  - Xin H
AUID- ORCID: 0000-0001-8781-1815
AD  - Department of Radiology, Shandong Provincial Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, Shandong, China.
FAU - Wen, Hongwei
AU  - Wen H
AUID- ORCID: 0000-0003-1717-7235
AD  - Key Laboratory of Cognition and Personality (Ministry of Education), Chongqing, 
      China.
AD  - School of Psychology, Southwest University, Chongqing, China.
FAU - Feng, Mengmeng
AU  - Feng M
AUID- ORCID: 0000-0001-5349-2780
AD  - Department of Radiology, Shandong Provincial Hospital, Cheeloo College of 
      Medicine, Shandong University, Jinan, Shandong, China.
FAU - Gao, Yian
AU  - Gao Y
AUID- ORCID: 0000-0002-3444-3382
AD  - Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong 
      First Medical University, Jinan, Shandong, China.
FAU - Sui, Chaofan
AU  - Sui C
AUID- ORCID: 0000-0002-1049-3772
AD  - Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong 
      First Medical University, Jinan, Shandong, China.
FAU - Zhang, Nan
AU  - Zhang N
AUID- ORCID: 0000-0002-6202-9349
AD  - Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong 
      First Medical University, Jinan, Shandong, China.
FAU - Liang, Changhu
AU  - Liang C
AUID- ORCID: 0000-0003-3796-2978
AD  - Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong 
      First Medical University, Jinan, Shandong, China.
FAU - Guo, Lingfei
AU  - Guo L
AUID- ORCID: 0000-0002-4885-625X
AD  - Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong 
      First Medical University, Jinan, Shandong, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220215
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
SB  - IM
MH  - Brain/diagnostic imaging
MH  - Brain Mapping
MH  - *Cerebral Small Vessel Diseases/complications/diagnostic imaging
MH  - Gyrus Cinguli
MH  - Humans
MH  - *Magnetic Resonance Imaging/methods
PMC - PMC9057099
OTO - NOTNLM
OT  - cerebral microbleeds
OT  - cerebral small vessel disease
OT  - functional connectivity
OT  - graph theory
OT  - topological organization
COIS- The authors declare that they have no competing interests.
EDAT- 2022/02/16 06:00
MHDA- 2022/05/04 06:00
PMCR- 2022/02/15
CRDT- 2022/02/15 09:15
PHST- 2022/01/13 00:00 [revised]
PHST- 2021/11/25 00:00 [received]
PHST- 2022/01/31 00:00 [accepted]
PHST- 2022/02/16 06:00 [pubmed]
PHST- 2022/05/04 06:00 [medline]
PHST- 2022/02/15 09:15 [entrez]
PHST- 2022/02/15 00:00 [pmc-release]
AID - HBM25808 [pii]
AID - 10.1002/hbm.25808 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2022 Jun 1;43(8):2607-2620. doi: 10.1002/hbm.25808. Epub 2022 Feb 
      15.