PMID- 35167921
OWN - NLM
STAT- MEDLINE
DCOM- 20220419
LR  - 20220719
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 185
DP  - 2022 Mar
TI  - Longitudinal association of Apolipoprotein E polymorphism with lipid profile, 
      type 2 diabetes and metabolic syndrome: Results from a 15 year follow-up study.
PG  - 109778
LID - S0168-8227(22)00590-3 [pii]
LID - 10.1016/j.diabres.2022.109778 [doi]
AB  - AIMS: To examine the association of different APOE alleles with type 2 diabetes 
      mellitus (T2DM) and metabolic syndrome (MetS) as well as the influence of 
      high-sensitive C-reactive protein (hs-CRP) on these associations. METHODS: We 
      analyzed data from 3917 participants aged 20-81 years of the population-based 
      Study of Health in Pomerania (SHIP) from Northeast Germany with a median 
      follow-up time of 10.8 years. Linear and logistic mixed models were performed to 
      test the association of APOE alleles with T2DM and MetS. RESULTS: We observed 393 
      T2DM and 1411 MetS events at baseline, and 576 T2DM and 1342 MetS events over the 
      follow-up. The E4 carriers had a lower odds of developing T2DM (OR: 0.47 [0.24, 
      0.94]) than E3 homozygotes even after adjustment for potential confounders. The 
      E2 carriers showed no associations. The inverse association between E4 alleles 
      and T2DM moderately attenuated after adjustment for hs-CRP levels. The lower odds 
      of developing T2DM in E4 carriers was more pronounced in participants without 
      obesity, hypertension or MetS. However, both E2 and E4 carriers had higher odds 
      of developing MetS (E2 OR: 1.45 [1.03, 2.03]; E4 OR: 1.56 [1.17, 2.09]) than E3 
      homozygotes. CONCLUSIONS: While the presence of APOE E4 allele might increase the 
      chance of MetS through its major action on lipids, E4 allele might offer a 
      protection towards T2DM through its influence on inflammation.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Pitchika, Anitha
AU  - Pitchika A
AD  - Institute for Community Medicine, University Medicine Greifswald, Greifswald, 
      Germany. Electronic address: anitha.pitchika@uni-greifswald.de.
FAU - Markus, Marcello Ricardo Paulista
AU  - Markus MRP
AD  - Department of Internal Medicine B, University Medicine Greifswald, Greifswald, 
      Germany; German Center for Cardiovascular Research (DZHK e.V.), Partner site 
      Greifswald, Greifswald, Germany; DZD (German Center for Diabetes Research), Site 
      Greifswald, Greifswald, Germany.
FAU - Schipf, Sabine
AU  - Schipf S
AD  - Institute for Community Medicine, University Medicine Greifswald, Greifswald, 
      Germany; Department of Medicine A, University Medicine Greifswald, Greifswald, 
      Germany.
FAU - Teumer, Alexander
AU  - Teumer A
AD  - Institute for Community Medicine, University Medicine Greifswald, Greifswald, 
      Germany; German Center for Cardiovascular Research (DZHK e.V.), Partner site 
      Greifswald, Greifswald, Germany.
FAU - Van der Auwera, Sandra
AU  - Van der Auwera S
AD  - Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 
      Greifswald, Germany; German Center for Neurodegenerative Diseases (DZNE), Site 
      Rostock, Greifswald, Germany.
FAU - Nauck, Matthias
AU  - Nauck M
AD  - German Center for Cardiovascular Research (DZHK e.V.), Partner site Greifswald, 
      Greifswald, Germany; Institute of Clinical Chemistry and Laboratory Medicine, 
      University Medicine Greifswald, Greifswald, Germany.
FAU - Dorr, Marcus
AU  - Dorr M
AD  - Department of Internal Medicine B, University Medicine Greifswald, Greifswald, 
      Germany; German Center for Cardiovascular Research (DZHK e.V.), Partner site 
      Greifswald, Greifswald, Germany.
FAU - Felix, Stephan
AU  - Felix S
AD  - Department of Internal Medicine B, University Medicine Greifswald, Greifswald, 
      Germany; German Center for Cardiovascular Research (DZHK e.V.), Partner site 
      Greifswald, Greifswald, Germany.
FAU - Jorgen Grabe, Hans
AU  - Jorgen Grabe H
AD  - Department of Psychiatry and Psychotherapy, University Medicine Greifswald, 
      Greifswald, Germany; German Center for Neurodegenerative Diseases (DZNE), Site 
      Rostock, Greifswald, Germany.
FAU - Volzke, Henry
AU  - Volzke H
AD  - Institute for Community Medicine, University Medicine Greifswald, Greifswald, 
      Germany; German Center for Cardiovascular Research (DZHK e.V.), Partner site 
      Greifswald, Greifswald, Germany; DZD (German Center for Diabetes Research), Site 
      Greifswald, Greifswald, Germany.
FAU - Ittermann, Till
AU  - Ittermann T
AD  - Institute for Community Medicine, University Medicine Greifswald, Greifswald, 
      Germany.
LA  - eng
PT  - Journal Article
DEP - 20220212
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (ApoE protein, human)
RN  - 0 (Apolipoproteins E)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Alleles
MH  - Apolipoproteins E/*genetics
MH  - C-Reactive Protein
MH  - *Diabetes Mellitus, Type 2/epidemiology/genetics
MH  - Follow-Up Studies
MH  - Genotype
MH  - Humans
MH  - *Metabolic Syndrome/epidemiology/genetics
MH  - Polymorphism, Genetic
OTO - NOTNLM
OT  - APOE
OT  - Inflammation
OT  - Lipids
OT  - Metabolic syndrome
OT  - Type 2 diabetes mellitus
EDAT- 2022/02/16 06:00
MHDA- 2022/04/20 06:00
CRDT- 2022/02/15 20:12
PHST- 2021/11/29 00:00 [received]
PHST- 2022/01/24 00:00 [revised]
PHST- 2022/02/08 00:00 [accepted]
PHST- 2022/02/16 06:00 [pubmed]
PHST- 2022/04/20 06:00 [medline]
PHST- 2022/02/15 20:12 [entrez]
AID - S0168-8227(22)00590-3 [pii]
AID - 10.1016/j.diabres.2022.109778 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2022 Mar;185:109778. doi: 10.1016/j.diabres.2022.109778. 
      Epub 2022 Feb 12.